ID   SPSB3_BOVIN             Reviewed;         345 AA.
AC   Q3MHZ2;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=SPRY domain-containing SOCS box protein 3;
DE            Short=SSB-3;
GN   Name=SPSB3; Synonyms=SSB3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be a substrate recognition component of a SCF-like ECS
CC       (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase
CC       complex which mediates the ubiquitination and subsequent proteasomal
CC       degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Interacts with MET. {ECO:0000250}.
CC   -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC       BC complex, an adapter module in different E3 ubiquitin ligase
CC       complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPSB family. {ECO:0000305}.
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DR   EMBL; BC104512; AAI04513.1; -; mRNA.
DR   RefSeq; NP_001029678.1; NM_001034506.1.
DR   RefSeq; XP_005224505.1; XM_005224448.3.
DR   RefSeq; XP_010817394.1; XM_010819092.2.
DR   AlphaFoldDB; Q3MHZ2; -.
DR   SMR; Q3MHZ2; -.
DR   STRING; 9913.ENSBTAP00000022024; -.
DR   PaxDb; Q3MHZ2; -.
DR   Ensembl; ENSBTAT00000022024; ENSBTAP00000022024; ENSBTAG00000016558.
DR   GeneID; 515661; -.
DR   KEGG; bta:515661; -.
DR   CTD; 90864; -.
DR   VEuPathDB; HostDB:ENSBTAG00000016558; -.
DR   VGNC; VGNC:35248; SPSB3.
DR   eggNOG; KOG3953; Eukaryota.
DR   GeneTree; ENSGT01030000234629; -.
DR   HOGENOM; CLU_042284_0_0_1; -.
DR   InParanoid; Q3MHZ2; -.
DR   OMA; VRDCRCG; -.
DR   OrthoDB; 1269591at2759; -.
DR   TreeFam; TF312822; -.
DR   Reactome; R-BTA-8951664; Neddylation.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000016558; Expressed in retina and 109 other tissues.
DR   ExpressionAtlas; Q3MHZ2; baseline and differential.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd12876; SPRY_SOCS3; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035754; SPRY_SPSB3.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..345
FT                   /note="SPRY domain-containing SOCS box protein 3"
FT                   /id="PRO_0000278777"
FT   DOMAIN          84..273
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT   DOMAIN          263..314
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT   REGION          38..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          320..345
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   345 AA;  38181 MW;  CFFC28BABD5F78EA CRC64;
     MARRPRSSRA WHFVLSAARR DADARAVALA GTANWGYDSD GQHSDSDSDP ECASLPSSIP
     SAVPVTGESF CDCDSQSEAF CGSLHTAHRG RDCRCGEEDE YFDWVWDDLN KSSATLLSCD
     NRKVSFHMEY SCGTAAIRGT KELGEGQHFW EIKMTSPVYG TDMMVGIGTS DVDLDKYHHT
     FCSLLGRDED SWGLSYTGLL HHKGDKTSFS SRFGQGSIIG VHLDTWHGTL TFFKNRKCIG
     VAATQLQNKR FYPMVCSTAA KSSMKVIRSC ASVTSLQYLC CFRLRQLRPG SGDTLEGLPL
     PPGLKQVLHH KLGWVLSMSR QPPAPSPAAN GPEPRRCQRK RCRRT