ID   SPSB3_XENLA             Reviewed;         360 AA.
AC   Q5M9B1;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=SPRY domain-containing SOCS box protein 3;
DE            Short=SSB-3;
GN   Name=spsb3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be a substrate recognition component of a SCF-like ECS
CC       (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase
CC       complex which mediates the ubiquitination and subsequent proteasomal
CC       degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC       BC complex, an adapter module in different E3 ubiquitin ligase
CC       complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPSB family. {ECO:0000305}.
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DR   EMBL; BC087357; AAH87357.1; -; mRNA.
DR   RefSeq; NP_001088836.1; NM_001095367.1.
DR   RefSeq; XP_018090047.1; XM_018234558.1.
DR   AlphaFoldDB; Q5M9B1; -.
DR   SMR; Q5M9B1; -.
DR   DNASU; 496145; -.
DR   GeneID; 496145; -.
DR   KEGG; xla:496145; -.
DR   CTD; 496145; -.
DR   Xenbase; XB-GENE-971067; spsb3.L.
DR   OMA; VRDCRCG; -.
DR   OrthoDB; 1269591at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 496145; Expressed in testis and 19 other tissues.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd12876; SPRY_SOCS3; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035754; SPRY_SPSB3.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..360
FT                   /note="SPRY domain-containing SOCS box protein 3"
FT                   /id="PRO_0000278780"
FT   DOMAIN          84..274
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT   DOMAIN          264..315
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT   REGION          21..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          322..350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..39
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..54
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   360 AA;  40048 MW;  0D46620E275A975B CRC64;
     MARRPRNSRA WRFVLSGVRR DQDGRSPALH AEEEAWGYDS DGQHSNSDSD TDLLTLPPSI
     PSAVPVTGES YCDCDSQNDP YCSSLHPFRQ IKSCQCGEED NYFDWVWDDC SKSTATVLSC
     DDRKVSFHME YSCGTAAIRG NKMLTEGQHF WEIKMTSPVY GTDMMVGIGT SDVNLDKYRH
     TFCSLLGKDA ESWGLSYTGL LQHKGDKSNF SSRFGQGSII GVHLDTWHGV LTFYKNRKRI
     GVAATQLRNK KLFPLVCSTA AKSSMKVIRS CCCRTSLQYL CCARLRQLLP GSVDSLEVLP
     LPPGLKQVLS NKLGWVLQMG SNRSSQHKGD GSATTSCGSY SDSSCTPGHD NCQRKRCRRI