ID   SPSB3_XENTR             Reviewed;         360 AA.
AC   Q28DT9;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=SPRY domain-containing SOCS box protein 3;
DE            Short=SSB-3;
GN   Name=spsb3; ORFNames=TGas007f05.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be a substrate recognition component of a SCF-like ECS
CC       (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase
CC       complex which mediates the ubiquitination and subsequent proteasomal
CC       degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC       BC complex, an adapter module in different E3 ubiquitin ligase
CC       complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPSB family. {ECO:0000305}.
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DR   EMBL; CR848600; CAJ83905.1; -; mRNA.
DR   RefSeq; NP_001017350.1; NM_001017350.2.
DR   RefSeq; XP_012825936.1; XM_012970482.2.
DR   RefSeq; XP_012825937.1; XM_012970483.2.
DR   RefSeq; XP_012825938.1; XM_012970484.2.
DR   RefSeq; XP_017952622.1; XM_018097133.1.
DR   AlphaFoldDB; Q28DT9; -.
DR   SMR; Q28DT9; -.
DR   STRING; 8364.ENSXETP00000022767; -.
DR   PaxDb; Q28DT9; -.
DR   Ensembl; ENSXETT00000022767; ENSXETP00000022767; ENSXETG00000010355.
DR   GeneID; 550104; -.
DR   KEGG; xtr:550104; -.
DR   CTD; 90864; -.
DR   Xenbase; XB-GENE-971062; spsb3.
DR   eggNOG; ENOG502QTS2; Eukaryota.
DR   HOGENOM; CLU_042284_0_0_1; -.
DR   InParanoid; Q28DT9; -.
DR   OMA; FPRENCF; -.
DR   OrthoDB; 1269591at2759; -.
DR   PhylomeDB; Q28DT9; -.
DR   TreeFam; TF312822; -.
DR   Reactome; R-XTR-8951664; Neddylation.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000010355; Expressed in testis and 12 other tissues.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd12876; SPRY_SOCS3; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035754; SPRY_SPSB3.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..360
FT                   /note="SPRY domain-containing SOCS box protein 3"
FT                   /id="PRO_0000278781"
FT   DOMAIN          85..274
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT   DOMAIN          264..315
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT   REGION          20..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          323..350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        323..348
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   360 AA;  40108 MW;  FACBD1AE8143AEBE CRC64;
     MARRPRNSRA WRFVLSGVRR DQDARSPTLP AEEEAWGYDS DGQHSNSDSD TDLLHLPPSI
     PSAVPVTGES YCDCDSQNDP YCSSLHTFHQ IKSCQCGEED NYFDWVWDDC SKSTATVLSC
     DNRKVSFHME YSCGTAAIRG NRMLTEGQHF WEIKMTSPVY GTDMMVGIGT SDVNLDKYRH
     TFCSLLGKDA ESWGLSYTGL LQHKGDKSNF SSRFGQGSII GVHLDTWHGV LTFYKNRKCI
     GVAATQLRNK KLFPMVCSTA AKSSMKVIRS CCCRTSLQYL CCARLRQLLP DSVDSLEVLP
     LPPGLKQVLG NKLGWVLQMG SNRSNQHKGD TSATTSCGSD SDSSCTPGQD DCQRKRCRRI