SPT12_HUMAN
ID SPT12_HUMAN Reviewed; 190 AA.
AC Q7Z6I5; A0AVA8; B2RMW1;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Spermatogenesis-associated protein 12;
DE AltName: Full=Spermatogenesis-related protein 5;
GN Name=SPATA12; Synonyms=SRG5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=15603706;
RA Li D., Lu G.X.;
RT "Identification and expression of a novel human testis-specific gene by
RT digital differential display.";
RL Chin. Med. J. 117:1791-1796(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=15490870;
RA Li D., Lu G.X., Fu J.J., Mo Y.Q., Xing X.W., Liu G.;
RT "Molecular cloning and expression analysis of a novel human testis-specific
RT gene.";
RL Yi Chuan Xue Bao 31:545-551(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q7Z6I5; P01023: A2M; NbExp=3; IntAct=EBI-10696971, EBI-640741;
CC Q7Z6I5; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-10696971, EBI-11954519;
CC Q7Z6I5; Q92870-2: APBB2; NbExp=3; IntAct=EBI-10696971, EBI-21535880;
CC Q7Z6I5; P46379-2: BAG6; NbExp=3; IntAct=EBI-10696971, EBI-10988864;
CC Q7Z6I5; P55212: CASP6; NbExp=3; IntAct=EBI-10696971, EBI-718729;
CC Q7Z6I5; P28329-3: CHAT; NbExp=3; IntAct=EBI-10696971, EBI-25837549;
CC Q7Z6I5; Q96AQ7: CIDEC; NbExp=3; IntAct=EBI-10696971, EBI-14151404;
CC Q7Z6I5; Q02930-3: CREB5; NbExp=3; IntAct=EBI-10696971, EBI-10192698;
CC Q7Z6I5; O75190-2: DNAJB6; NbExp=3; IntAct=EBI-10696971, EBI-12593112;
CC Q7Z6I5; O14645: DNALI1; NbExp=3; IntAct=EBI-10696971, EBI-395638;
CC Q7Z6I5; P50570-2: DNM2; NbExp=3; IntAct=EBI-10696971, EBI-10968534;
CC Q7Z6I5; P41091: EIF2S3; NbExp=3; IntAct=EBI-10696971, EBI-1054228;
CC Q7Z6I5; P22607: FGFR3; NbExp=3; IntAct=EBI-10696971, EBI-348399;
CC Q7Z6I5; Q0VDC6: FKBP1A; NbExp=3; IntAct=EBI-10696971, EBI-10226858;
CC Q7Z6I5; O43559: FRS3; NbExp=3; IntAct=EBI-10696971, EBI-725515;
CC Q7Z6I5; Q8TB36: GDAP1; NbExp=3; IntAct=EBI-10696971, EBI-11110431;
CC Q7Z6I5; P06396: GSN; NbExp=3; IntAct=EBI-10696971, EBI-351506;
CC Q7Z6I5; O14964: HGS; NbExp=3; IntAct=EBI-10696971, EBI-740220;
CC Q7Z6I5; P49639: HOXA1; NbExp=3; IntAct=EBI-10696971, EBI-740785;
CC Q7Z6I5; P54652: HSPA2; NbExp=3; IntAct=EBI-10696971, EBI-356991;
CC Q7Z6I5; P42858: HTT; NbExp=3; IntAct=EBI-10696971, EBI-466029;
CC Q7Z6I5; O14901: KLF11; NbExp=3; IntAct=EBI-10696971, EBI-948266;
CC Q7Z6I5; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-10696971, EBI-3957672;
CC Q7Z6I5; P51608: MECP2; NbExp=3; IntAct=EBI-10696971, EBI-1189067;
CC Q7Z6I5; Q9BVL2: NUP58; NbExp=3; IntAct=EBI-10696971, EBI-2811583;
CC Q7Z6I5; D3DTS7: PMP22; NbExp=3; IntAct=EBI-10696971, EBI-25882629;
CC Q7Z6I5; Q7Z3K3: POGZ; NbExp=3; IntAct=EBI-10696971, EBI-1389308;
CC Q7Z6I5; P49591: SARS1; NbExp=3; IntAct=EBI-10696971, EBI-1053431;
CC Q7Z6I5; Q92922: SMARCC1; NbExp=3; IntAct=EBI-10696971, EBI-355653;
CC Q7Z6I5; Q16637: SMN2; NbExp=3; IntAct=EBI-10696971, EBI-395421;
CC Q7Z6I5; O14656-2: TOR1A; NbExp=3; IntAct=EBI-10696971, EBI-25847109;
CC Q7Z6I5; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-10696971, EBI-741480;
CC Q7Z6I5; Q9Y649; NbExp=3; IntAct=EBI-10696971, EBI-25900580;
CC -!- TISSUE SPECIFICITY: Expressed in testis. {ECO:0000269|PubMed:15490870,
CC ECO:0000269|PubMed:15603706}.
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DR EMBL; AY221117; AAP50852.1; -; mRNA.
DR EMBL; BC126274; AAI26275.1; -; mRNA.
DR EMBL; BC136498; AAI36499.1; -; mRNA.
DR CCDS; CCDS2879.1; -.
DR RefSeq; NP_859078.1; NM_181727.1.
DR RefSeq; XP_011531978.1; XM_011533676.2.
DR AlphaFoldDB; Q7Z6I5; -.
DR BioGRID; 131685; 11.
DR IntAct; Q7Z6I5; 35.
DR STRING; 9606.ENSP00000335392; -.
DR BioMuta; SPATA12; -.
DR MassIVE; Q7Z6I5; -.
DR PaxDb; Q7Z6I5; -.
DR PRIDE; Q7Z6I5; -.
DR Antibodypedia; 31514; 33 antibodies from 14 providers.
DR DNASU; 353324; -.
DR Ensembl; ENST00000334325.2; ENSP00000335392.1; ENSG00000186451.2.
DR GeneID; 353324; -.
DR KEGG; hsa:353324; -.
DR MANE-Select; ENST00000334325.2; ENSP00000335392.1; NM_181727.2; NP_859078.1.
DR UCSC; uc003dij.1; human.
DR CTD; 353324; -.
DR GeneCards; SPATA12; -.
DR HGNC; HGNC:23221; SPATA12.
DR HPA; ENSG00000186451; Tissue enriched (testis).
DR MIM; 609869; gene.
DR neXtProt; NX_Q7Z6I5; -.
DR OpenTargets; ENSG00000186451; -.
DR PharmGKB; PA134888733; -.
DR VEuPathDB; HostDB:ENSG00000186451; -.
DR eggNOG; ENOG502TEHX; Eukaryota.
DR GeneTree; ENSGT00390000008817; -.
DR HOGENOM; CLU_1427572_0_0_1; -.
DR InParanoid; Q7Z6I5; -.
DR OMA; CQSETCQ; -.
DR OrthoDB; 1484204at2759; -.
DR PhylomeDB; Q7Z6I5; -.
DR TreeFam; TF342116; -.
DR PathwayCommons; Q7Z6I5; -.
DR SignaLink; Q7Z6I5; -.
DR BioGRID-ORCS; 353324; 7 hits in 1063 CRISPR screens.
DR GenomeRNAi; 353324; -.
DR Pharos; Q7Z6I5; Tbio.
DR PRO; PR:Q7Z6I5; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q7Z6I5; protein.
DR Bgee; ENSG00000186451; Expressed in sperm and 52 other tissues.
DR ExpressionAtlas; Q7Z6I5; baseline and differential.
DR Genevisible; Q7Z6I5; HS.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..190
FT /note="Spermatogenesis-associated protein 12"
FT /id="PRO_0000251198"
SQ SEQUENCE 190 AA; 20418 MW; 2E3315C943EBA207 CRC64;
MSSSALTCGS TLEKSGDTWE MKALDSSRLV PWPPRGLGSS TQHPNKPHCA LASCQGPGVL
PGAASALPEL TFQGDVCQSE TCQRYLQAAI SLDIAVSQIN LLGRPSSPPA LLIQQGSCEQ
VIHNSTPQFL GMEDGDNERT TGWLWRLCED IDAEPSSTGC SRSNQLTFTE GCFVRSLSTV
YSNTHIHTHL
