ID   SPT16_MACFA             Reviewed;         569 AA.
AC   Q4R3V2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Spermatogenesis-associated protein 16;
GN   Name=SPATA16; ORFNames=QtsA-13978;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential for spermiogenesis and male fertility (By
CC       similarity). Involved in the formation of sperm acrosome during
CC       spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q8C636}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:Q8C636}.
CC       Cytoplasmic vesicle, secretory vesicle, acrosome
CC       {ECO:0000250|UniProtKB:Q8C636}. Note=Shift from Golgi to sperm
CC       acrosome. {ECO:0000250|UniProtKB:Q8C636}.
CC   -!- SIMILARITY: Belongs to the SPATA16 family. {ECO:0000305}.
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DR   EMBL; AB179163; BAE02214.1; -; mRNA.
DR   RefSeq; NP_001270675.1; NM_001283746.1.
DR   AlphaFoldDB; Q4R3V2; -.
DR   SMR; Q4R3V2; -.
DR   STRING; 9541.XP_005548489.1; -.
DR   PRIDE; Q4R3V2; -.
DR   GeneID; 101926490; -.
DR   CTD; 83893; -.
DR   eggNOG; ENOG502RSQ1; Eukaryota.
DR   OrthoDB; 548331at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0001669; C:acrosomal vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007286; P:spermatid development; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR029161; SPATA16.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR47228; PTHR47228; 1.
DR   Pfam; PF15015; NYD-SP12_N; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Developmental protein; Differentiation;
KW   Golgi apparatus; Reference proteome; Spermatogenesis.
FT   CHAIN           1..569
FT                   /note="Spermatogenesis-associated protein 16"
FT                   /id="PRO_0000315831"
SQ   SEQUENCE   569 AA;  65312 MW;  A294E4BD7A869012 CRC64;
     MDAGSSRSLE NAVNKIYHDQ LVPKINTSKK MSTLAHPPNI LEMPQEIKKN CGGKQVEITL
     ERIKMTKSIK EKQSNDLEKA AFKRKAEGEE KPTRKKEAKI IELDNQLITM PLPHIPLKNI
     MDVEMKLVYI DEVGVRYEFV ESFMSTGSQP TCRVAEIVDP LSVPNFSFLP QIDKWLQVAL
     KDASSCYRQK KYALAAGQFR TALELCSKGA VLEEPFDASA EDIASVASFI ETKLVTCYLR
     MRKPDLALNH AHRSIVLNPA YFRNHLRQAT VFRCLERYSE AARSAMIADY MFWLGGGREQ
     SISKLIKLYW QAMIEEAITR AESFSVMYTP FATKIRADKI EKVKDVFTKT HPAYAEYIYT
     DLQTLHMLPQ TVDWSSFPPQ QYLLTLGFKN KEDGKFLEKI SSRKLPIFTE HKTPFGLTRE
     DTVRQMETMG KRILPILDFI RSTQLNGSFP ASSGVMEKLQ YAGLLSQLQR VKEQSQVINQ
     AMAELATIPY LRDISQQEAE LLQSLMADAM DTLEGRRNDN ERVWNTIQKV GQIEDFLYQL
     EDSFLKTKKL RTARRQKTKM KRLQIVQQS