ID   ABHD8_XENLA             Reviewed;         424 AA.
AC   Q6AX59;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Protein ABHD8 {ECO:0000305};
DE            EC=3.-.-.-;
DE   AltName: Full=Alpha/beta hydrolase domain-containing protein 8 {ECO:0000305};
DE            Short=Abhydrolase domain-containing protein 8 {ECO:0000250|UniProtKB:Q96I13};
GN   Name=abhd8 {ECO:0000250|UniProtKB:Q96I13};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
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DR   EMBL; BC079743; AAH79743.1; -; mRNA.
DR   RefSeq; NP_001087413.1; NM_001093944.1.
DR   AlphaFoldDB; Q6AX59; -.
DR   SMR; Q6AX59; -.
DR   ESTHER; xenla-q6ax59; ABHD8.
DR   DNASU; 447237; -.
DR   GeneID; 447237; -.
DR   KEGG; xla:447237; -.
DR   CTD; 447237; -.
DR   Xenbase; XB-GENE-1004076; abhd8.L.
DR   OrthoDB; 729023at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 447237; Expressed in brain and 14 other tissues.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR000639; Epox_hydrolase-like.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   PRINTS; PR00111; ABHYDROLASE.
DR   PRINTS; PR00412; EPOXHYDRLASE.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..424
FT                   /note="Protein ABHD8"
FT                   /id="PRO_0000281385"
FT   DOMAIN          168..270
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000255"
FT   REGION          120..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        243
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        361
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        389
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   424 AA;  47275 MW;  05E3457797BE7766 CRC64;
     MLTSIAERIM YCLTGKTPNS VGPVETSETS DGYDFLEVKP GRVLRVRHIL PSCPGDREEE
     ELFEEKNGGQ GLVHCKRRIT VYRNGQLVIE NLGATLRSEI LHCRNGNLEP AGTLEVELSD
     FTSTGNEGGG KESDVPPGKR RKRKPKKVIM VDCQRQVKCC KGTHSDVVLF FIHGVGGSLD
     IWKEQLDFFS KLGYEVVAPD LVGHGASTAP QIGAAYTFYA LAEDMRCIFK RYAKKRNILV
     GHSYGVSFCT FLAHEYPDLV HKVVMINGGG PTALEPSLCS IFNMPTCVLH CLSPCLAWSF
     LKAGFARQGA KEKQLLREGN AFNVSSFVLR AMMSGQYWPE GDEVYHAELT VPILLVHGMH
     DKFVPLDEDQ RMAEILLITF LKIIEEGSHM VMLECPETVN TLLHEFFLWQ PETQNTTAED
     TGNE