SPT17_HUMAN
ID SPT17_HUMAN Reviewed; 361 AA.
AC Q96L03; A5D6N2;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Spermatogenesis-associated protein 17;
GN Name=SPATA17;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RA Deng Y., Lu G.-X.;
RT "Molecular cloning of HSRG-11 gene related to apoptosis of spermatogenic
RT cells.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96L03; P27797: CALR; NbExp=3; IntAct=EBI-13322423, EBI-1049597;
CC Q96L03; P36957: DLST; NbExp=3; IntAct=EBI-13322423, EBI-351007;
CC Q96L03; Q8TDX7: NEK7; NbExp=3; IntAct=EBI-13322423, EBI-1055945;
CC Q96L03; Q8N131: TMEM123; NbExp=3; IntAct=EBI-13322423, EBI-749248;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; AY963797; AAY33662.1; -; mRNA.
DR EMBL; AK098591; BAC05343.1; -; mRNA.
DR EMBL; AC097061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL354659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL445428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471100; EAW93332.1; -; Genomic_DNA.
DR EMBL; BC014608; AAH14608.1; -; mRNA.
DR CCDS; CCDS1519.1; -.
DR RefSeq; NP_620151.1; NM_138796.3.
DR RefSeq; XP_005273109.1; XM_005273052.1.
DR AlphaFoldDB; Q96L03; -.
DR BioGRID; 126095; 5.
DR IntAct; Q96L03; 5.
DR STRING; 9606.ENSP00000355900; -.
DR iPTMnet; Q96L03; -.
DR PhosphoSitePlus; Q96L03; -.
DR BioMuta; SPATA17; -.
DR DMDM; 74751996; -.
DR MassIVE; Q96L03; -.
DR MaxQB; Q96L03; -.
DR PaxDb; Q96L03; -.
DR PeptideAtlas; Q96L03; -.
DR PRIDE; Q96L03; -.
DR ProteomicsDB; 77131; -.
DR Antibodypedia; 34622; 61 antibodies from 19 providers.
DR DNASU; 128153; -.
DR Ensembl; ENST00000366933.5; ENSP00000355900.4; ENSG00000162814.11.
DR GeneID; 128153; -.
DR KEGG; hsa:128153; -.
DR MANE-Select; ENST00000366933.5; ENSP00000355900.4; NM_138796.4; NP_620151.1.
DR UCSC; uc001hlh.2; human.
DR CTD; 128153; -.
DR DisGeNET; 128153; -.
DR GeneCards; SPATA17; -.
DR HGNC; HGNC:25184; SPATA17.
DR HPA; ENSG00000162814; Tissue enhanced (testis).
DR MIM; 611032; gene.
DR neXtProt; NX_Q96L03; -.
DR OpenTargets; ENSG00000162814; -.
DR PharmGKB; PA144596270; -.
DR VEuPathDB; HostDB:ENSG00000162814; -.
DR eggNOG; ENOG502QS0S; Eukaryota.
DR GeneTree; ENSGT00390000011270; -.
DR HOGENOM; CLU_044264_0_0_1; -.
DR InParanoid; Q96L03; -.
DR OMA; YGHLPYG; -.
DR OrthoDB; 1199557at2759; -.
DR PhylomeDB; Q96L03; -.
DR TreeFam; TF329213; -.
DR PathwayCommons; Q96L03; -.
DR SignaLink; Q96L03; -.
DR BioGRID-ORCS; 128153; 13 hits in 1070 CRISPR screens.
DR ChiTaRS; SPATA17; human.
DR GenomeRNAi; 128153; -.
DR Pharos; Q96L03; Tbio.
DR PRO; PR:Q96L03; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96L03; protein.
DR Bgee; ENSG00000162814; Expressed in sperm and 104 other tissues.
DR ExpressionAtlas; Q96L03; baseline and differential.
DR Genevisible; Q96L03; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00612; IQ; 3.
DR SMART; SM00015; IQ; 3.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50096; IQ; 3.
PE 1: Evidence at protein level;
KW Calmodulin-binding; Cytoplasm; Reference proteome; Repeat.
FT CHAIN 1..361
FT /note="Spermatogenesis-associated protein 17"
FT /id="PRO_0000265933"
FT DOMAIN 32..61
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 55..84
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 91..120
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT VARIANT 16
FT /note="N -> S (in dbSNP:rs34652544)"
FT /id="VAR_051382"
SQ SEQUENCE 361 AA; 43499 MW; 31575B9E51AFF8A5 CRC64;
MATLARLQAR SSTVGNQYYF RNSVVDPFRK KENDAAVKIQ SWFRGCQVRA YIRHLNRIVT
IIQKWWRSFL GRKQYQLTVQ VAYYTMMMNL YNAMAVRIQR RWRGYRVRKY LFNYYYLKEY
LKVVSETNDA IRKALEEFAE MKEREEKKAN LEREEKKRDY QARKMHYLLS TKQIPGIYNS
PFRKEPDPWE LQLQKAKPLT HRRPKVKQKD STSLTDWLAC TSARSFPRSE ILPPINRKQC
QGPFRDITEV LEQRYRPLEP TLRVAEPIDE LKLAREELRR EEWLQNVNDN MFLPFSSYHK
NEKYIPSMHL SSKYGPISYK EQFRSENPKK WICDKDFQTV LPSFELFSKY GKLYSKAGQI
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