SPT17_MOUSE
ID SPT17_MOUSE Reviewed; 379 AA.
AC Q9D552; Q5FWA7; Q8BQE6;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Spermatogenesis-associated protein 17;
DE AltName: Full=Spermatogenesis-related protein 11;
GN Name=Spata17; Synonyms=Srg11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=15756417; DOI=10.1093/abbs/37.3.159;
RA Deng Y., Nie D.S., Wang J., Tan X.J., Nie Z.Y., Yang H.M., Hu L.S.,
RA Lu G.X.;
RT "Molecular cloning of MSRG-11 gene related to apoptosis of mouse
RT spermatogenic cells.";
RL Acta Biochim. Biophys. Sin. 37:159-166(2005).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15756417}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9D552-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D552-2; Sequence=VSP_021906, VSP_021907;
CC Name=3;
CC IsoId=Q9D552-3; Sequence=VSP_021908, VSP_021909;
CC -!- TISSUE SPECIFICITY: Strongly expressed in adult testis but weakly
CC expressed in the spleen and thymus. Strongly expressed in round and
CC elongating spermatids, and weakly or not expressed in spermatozoa.
CC {ECO:0000269|PubMed:15756417}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-17 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AK015780; BAB29973.1; -; mRNA.
DR EMBL; AK050925; BAC34462.1; -; mRNA.
DR EMBL; BC089520; AAH89520.1; -; mRNA.
DR EMBL; AY747687; AAW33969.1; -; mRNA.
DR CCDS; CCDS15604.1; -. [Q9D552-1]
DR CCDS; CCDS48479.1; -. [Q9D552-2]
DR RefSeq; NP_083124.1; NM_028848.3. [Q9D552-1]
DR RefSeq; NP_083343.1; NM_029067.1. [Q9D552-2]
DR RefSeq; XP_006497270.1; XM_006497207.2. [Q9D552-1]
DR AlphaFoldDB; Q9D552; -.
DR STRING; 10090.ENSMUSP00000106570; -.
DR iPTMnet; Q9D552; -.
DR PhosphoSitePlus; Q9D552; -.
DR PaxDb; Q9D552; -.
DR PRIDE; Q9D552; -.
DR ProteomicsDB; 257382; -. [Q9D552-1]
DR ProteomicsDB; 257383; -. [Q9D552-2]
DR ProteomicsDB; 257384; -. [Q9D552-3]
DR Antibodypedia; 34622; 61 antibodies from 19 providers.
DR Ensembl; ENSMUST00000027908; ENSMUSP00000027908; ENSMUSG00000026611. [Q9D552-1]
DR Ensembl; ENSMUST00000110945; ENSMUSP00000106570; ENSMUSG00000026611. [Q9D552-2]
DR Ensembl; ENSMUST00000183819; ENSMUSP00000138855; ENSMUSG00000026611. [Q9D552-1]
DR GeneID; 74717; -.
DR KEGG; mmu:74717; -.
DR UCSC; uc007dzt.2; mouse. [Q9D552-1]
DR UCSC; uc007dzw.2; mouse. [Q9D552-2]
DR CTD; 128153; -.
DR MGI; MGI:1921967; Spata17.
DR VEuPathDB; HostDB:ENSMUSG00000026611; -.
DR eggNOG; ENOG502QS0S; Eukaryota.
DR GeneTree; ENSGT00390000011270; -.
DR HOGENOM; CLU_044264_0_0_1; -.
DR InParanoid; Q9D552; -.
DR OMA; YGHLPYG; -.
DR OrthoDB; 1199557at2759; -.
DR PhylomeDB; Q9D552; -.
DR TreeFam; TF329213; -.
DR BioGRID-ORCS; 74717; 0 hits in 73 CRISPR screens.
DR PRO; PR:Q9D552; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9D552; protein.
DR Bgee; ENSMUSG00000026611; Expressed in spermatid and 60 other tissues.
DR ExpressionAtlas; Q9D552; baseline and differential.
DR Genevisible; Q9D552; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00612; IQ; 3.
DR SMART; SM00015; IQ; 3.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50096; IQ; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calmodulin-binding; Cytoplasm; Reference proteome;
KW Repeat.
FT CHAIN 1..379
FT /note="Spermatogenesis-associated protein 17"
FT /id="PRO_0000265935"
FT DOMAIN 48..77
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 71..100
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 107..136
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT VAR_SEQ 97..149
FT /note="AAYYTMKMNLYNEMAVRIQRRWRGFRIRKYCFNYYYLKEYLRAVSETNDAIR
FT E -> PPSPETAVDDNHAYGLLMQFLQIKEMTLELGFGENCE (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021908"
FT VAR_SEQ 150..379
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021909"
FT VAR_SEQ 190..192
FT /note="ISG -> HKH (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:15756417"
FT /id="VSP_021906"
FT VAR_SEQ 193..379
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:15756417"
FT /id="VSP_021907"
SQ SEQUENCE 379 AA; 45503 MW; 6092BDA6C31705A0 CRC64;
METNSNNFGE LQELKDMATL AKLLARAPFL ESQYYFRNRA VDSFRKFEND AAVMIQSWFR
GCQVRAYMRH LNRVVTIIQK WWRSYLGRKF YQLVVEAAYY TMKMNLYNEM AVRIQRRWRG
FRIRKYCFNY YYLKEYLRAV SETNDAIREA LEEFAEMKER EERKVLLERE EKQKDYQARK
MHYLLSTKQI SGIYNSPFRE HPDPWELRLQ KAKPLGHQKY TAEKGKTSQS PSNWLACTSV
HSFPQSESLP PISRKRCQGP FRDINEVLEQ RYKPLEPTLR VAEPINHLRL AREAFKQEER
MRNVQDKMFL PFSSYHKKEK YIPMIHSSSA YNSDSYGQKH FRSQDSKKWI SDKDFQTVLP
SFQLFSKYGK LYSKAGEIV
