ID   SPT19_RAT               Reviewed;         154 AA.
AC   Q920Q3;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Spermatogenesis-associated protein 19, mitochondrial;
DE   AltName: Full=Spermatogenic cell-specific gene 1 protein;
DE            Short=Spergen-1;
DE   Flags: Precursor;
GN   Name=Spata19; Synonyms=Spas1, Spergen1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   STRAIN=Wistar; TISSUE=Testis;
RX   PubMed=11967211; DOI=10.1095/biolreprod66.5.1462;
RA   Doiguchi M., Yamashita H., Ichinose J., Mori T., Shibata Y., Iida H.;
RT   "Complementary DNA cloning and characterization of rat spergen-1, a
RT   spermatogenic cell-specific gene-1, containing a mitochondria-targeting
RT   signal.";
RL   Biol. Reprod. 66:1462-1470(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26 AND SER-116, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Essential for sperm motility and male fertility (By
CC       similarity). Plays an important role in sperm motility by regulating
CC       the organization and function of the mitochondria and is also required
CC       for correct sperm midpiece assembly (By similarity).
CC       {ECO:0000250|UniProtKB:Q9DAQ9}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:Q9DAQ9}. Mitochondrion
CC       {ECO:0000269|PubMed:11967211}. Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:Q9DAQ9}. Note=Localizes to the midpiece of the
CC       sperm flagellum. {ECO:0000250|UniProtKB:Q9DAQ9}.
CC   -!- TISSUE SPECIFICITY: Expressed in the testis.
CC       {ECO:0000269|PubMed:11967211}.
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DR   EMBL; AB057408; BAB69061.1; -; mRNA.
DR   EMBL; BC081729; AAH81729.1; -; mRNA.
DR   RefSeq; NP_599211.1; NM_134384.1.
DR   AlphaFoldDB; Q920Q3; -.
DR   SMR; Q920Q3; -.
DR   STRING; 10116.ENSRNOP00000040918; -.
DR   iPTMnet; Q920Q3; -.
DR   PhosphoSitePlus; Q920Q3; -.
DR   PaxDb; Q920Q3; -.
DR   Ensembl; ENSRNOT00000051573; ENSRNOP00000040918; ENSRNOG00000031438.
DR   GeneID; 171403; -.
DR   KEGG; rno:171403; -.
DR   CTD; 219938; -.
DR   RGD; 620628; Spata19.
DR   GeneTree; ENSGT00390000002749; -.
DR   InParanoid; Q920Q3; -.
DR   OrthoDB; 1465928at2759; -.
DR   PhylomeDB; Q920Q3; -.
DR   PRO; PR:Q920Q3; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR   GO; GO:0036126; C:sperm flagellum; ISS:UniProtKB.
DR   GO; GO:0097225; C:sperm midpiece; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0030382; P:sperm mitochondrion organization; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR028219; SPATA19.
DR   PANTHER; PTHR36468; PTHR36468; 1.
DR   Pfam; PF15212; SPATA19; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium; Developmental protein; Differentiation; Flagellum;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein;
KW   Reference proteome; Spermatogenesis; Transit peptide.
FT   TRANSIT         1..24
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..154
FT                   /note="Spermatogenesis-associated protein 19,
FT                   mitochondrial"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000251611"
FT   MOD_RES         26
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         116
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   154 AA;  18041 MW;  645A8F4DC3718BD6 CRC64;
     MIITTWIMYI LARKSIGLPF PPRVNSDIEV EETEAVSVVQ HWLNKTEEEA SRSIKEKISI
     NDPCTQGHDI HVTRDLVKHR LSKCDMLTDP NQEVLEERTR IQFIRWSHTR IFQVPSEMMD
     DVIQERIDQV RRSVSHLRCD SSSDPCYRNS CSEC