ID   SPT21_MACFA             Reviewed;         696 AA.
AC   Q4R736;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Spermatogenesis-associated protein 21;
GN   Name=SPATA21; Synonyms=QtsA-16425;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the differentiation of haploid spermatids.
CC       {ECO:0000250}.
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DR   EMBL; AB168993; BAE01088.1; -; mRNA.
DR   RefSeq; NP_001272246.1; NM_001285317.1.
DR   AlphaFoldDB; Q4R736; -.
DR   STRING; 9541.XP_005544721.1; -.
DR   GeneID; 101925365; -.
DR   CTD; 374955; -.
DR   eggNOG; KOG0027; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR043520; SPT21/EFCAB3.
DR   PANTHER; PTHR47500; PTHR47500; 1.
DR   SMART; SM00054; EFh; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Coiled coil; Metal-binding; Reference proteome.
FT   CHAIN           1..696
FT                   /note="Spermatogenesis-associated protein 21"
FT                   /id="PRO_0000330687"
FT   DOMAIN          481..516
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   REGION          1..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          329..386
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          646..696
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          424..451
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        69..83
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..117
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        142..156
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        194..208
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..250
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        335..362
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         494
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         496
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         498
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         500
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         505
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ   SEQUENCE   696 AA;  76512 MW;  2950D20A7737AFA0 CRC64;
     MDNRNTQMYT EGRIKVPGTQ PSPGLRITIK RAGVEPTIPG VSQVMFPDAS EVGSRKQLSS
     ASGGPEKGPR YRDTFKEGPS ELRTQEQRPP AKPGKKQSSW VPQEGSQELQ AGQDQSELGL
     LPSWVPEGPE GLQQLGSGKE IEGQQRRQRN RGTGEDEPPE SCQGPGYQST LGHQADVVQP
     AEPCCPLAGR GQPLGDKRPK EADVPHIRPQ EAPPEPSPGA HGDSSQEAMP PTSTVAPEEK
     TASSFLPSMP GPTKTKGGGE AVETQPAPGP LPPPEVRDIG ERREPDRVQQ QPQKPVVAAG
     TQNLRKFRQG FMKCLLEMEK VEASHRRALK ARSLTAQKSP RTLTPVPTSS PSLPQTPASA
     PASGPSWARL SAPGPEPAPV GASVPTSTPC PVLLCPALDL GWRRMELSHH SSERTLSYAK
     ARQEPEEQSL QKLYQNREKS EEQLTLKQEE AFRSYFEIFN GPGEVDAQSL KNILLLMGFS
     VTPAQVEDAL MSADVNGDGH VDFKDFLAVM TDTRRFFCSV EQNALTDMAP HNPHTLLFEI
     LPLLVEMLAL PEAVLEEITN YYQKKLKAGT CKAQEMEAAI GRLRLQKQLP YNPQQEESSE
     VPERKVLSIL SRLKQQNYAP NLQSPYAQVP CIPLCPRMDK KMVRRKPTNH YVQDQCTTPG
     LAPDIRSPFF QSRSQGNREH NSDSRKWPSS VPSRTH