SPT21_YEAST
ID SPT21_YEAST Reviewed; 758 AA.
AC P35209; D6W002;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Protein SPT21;
GN Name=SPT21; OrderedLocusNames=YMR179W; ORFNames=YM8010.09;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8138180; DOI=10.1093/genetics/136.1.93;
RA Natsoulis G., Winston F., Boeke J.D.;
RT "The SPT10 and SPT21 genes of Saccharomyces cerevisiae.";
RL Genetics 136:93-105(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169872;
RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL Nature 387:90-93(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-454, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17287358; DOI=10.1073/pnas.0607084104;
RA Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,
RA Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
RT "Analysis of phosphorylation sites on proteins from Saccharomyces
RT cerevisiae by electron transfer dissociation (ETD) mass spectrometry.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
CC -!- FUNCTION: Required for normal transcription at a number of loci in
CC yeast.
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DR EMBL; L24436; AAA35078.1; -; Genomic_DNA.
DR EMBL; Z49808; CAA89912.1; -; Genomic_DNA.
DR EMBL; BK006946; DAA10076.1; -; Genomic_DNA.
DR PIR; S47866; S47866.
DR RefSeq; NP_013904.1; NM_001182685.1.
DR AlphaFoldDB; P35209; -.
DR BioGRID; 35357; 445.
DR DIP; DIP-2855N; -.
DR IntAct; P35209; 7.
DR MINT; P35209; -.
DR STRING; 4932.YMR179W; -.
DR iPTMnet; P35209; -.
DR PaxDb; P35209; -.
DR PRIDE; P35209; -.
DR EnsemblFungi; YMR179W_mRNA; YMR179W; YMR179W.
DR GeneID; 855217; -.
DR KEGG; sce:YMR179W; -.
DR SGD; S000004791; SPT21.
DR VEuPathDB; FungiDB:YMR179W; -.
DR eggNOG; ENOG502QU3A; Eukaryota.
DR HOGENOM; CLU_413915_0_0_1; -.
DR InParanoid; P35209; -.
DR OMA; QTNPMPA; -.
DR BioCyc; YEAST:G3O-32867-MON; -.
DR PRO; PR:P35209; -.
DR Proteomes; UP000002311; Chromosome XIII.
DR RNAct; P35209; protein.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:GOC.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0000183; P:rDNA heterochromatin assembly; IMP:SGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:SGD.
DR GO; GO:0030466; P:silent mating-type cassette heterochromatin assembly; IGI:SGD.
DR GO; GO:0031509; P:subtelomeric heterochromatin assembly; IMP:SGD.
DR InterPro; IPR042403; Spt21/Ams2.
DR PANTHER; PTHR39147; PTHR39147; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..758
FT /note="Protein SPT21"
FT /id="PRO_0000072162"
FT REGION 251..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 454
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17287358"
SQ SEQUENCE 758 AA; 84697 MW; 7DB3FCF7EE996705 CRC64;
MSELSQMTLK ILYTLDNGSN GSYLARSRAP KQVRVANIPS PFPTDSNEQT ELRIGAIHLK
TILHEIYLNS PEVLDHDTLK DGYDYNLYYR DICEVDEPLV SLGLLSGLRK KFHKNSPYQY
TENNIGEEES EERDEVTEEE YEDESFIVTG RVCSNVSALL RRSYSNISNK KGRVVNNQIP
EETLEVKLRF TKVITNLRTS GNNTTNSRIS CLQMPSSLPS ATLPFTPKSQ SLFKTNQIKN
SRNARTTITI NNTNSGTVGR RQTNPMPAPK AVRTQSLPIW NLKPNIANTG FPRNSIAHKI
YLADRKTEAN QQNNQHQNIA YEINTLQNDN TIQRTKIDDS VSKRFDFMLN KRKSTKKVSP
GIATIAKKPA SININPKQPP KTSGEKKAND KQTIVKVKNS NSKNSAKSTQ AGCRRSSVIE
HLNDHDDSIL SDILSEPGIE GQKLQQKQKG RKISLTSEND KENIPPQSIT SKENKLEGDL
DFNAEFPMSD FSDVVFKDEM GWFSNFNCNF FESPTSASAS QLNQQNLKPS ITLNDPNTCN
TIALENEDVS ELETAQNNKI SLPSDVDKTS PIDSLSIPLI ELTHSSSTTN MQRISIKEGS
TLNITDSNNA TPCDNDIKDR KASVIDSDNT KPQAGLINFS TPADQPASDN NVTASKKLTS
MLETQQSKRS HEEVLDEEEE EEALKKQKAI PSSPCGMFNY HQPMELSEDI VEEEQGHNIG
DDNESDKTND LFSTFIHSGI RVSQVVTSPI GEFQSIKH