ID   SPT22_BOVIN             Reviewed;         364 AA.
AC   Q2TA20;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Spermatogenesis-associated protein 22;
GN   Name=SPATA22;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Meiosis-specific protein required for homologous
CC       recombination in meiosis I. {ECO:0000250|UniProtKB:Q5SV06}.
CC   -!- SUBUNIT: Component of a multiprotein complex with MEIOB and RPA2.
CC       Interacts with the complex BRME1:HSF2BP:BRCA2.
CC       {ECO:0000250|UniProtKB:Q5SV06}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q5SV06}.
CC       Note=Localizes on meiotic chromosome axes. Accumulates on resected DNA.
CC       Localization is dependent on MEIOB. {ECO:0000250|UniProtKB:Q5SV06}.
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DR   EMBL; BC111158; AAI11159.1; -; mRNA.
DR   RefSeq; NP_001033275.1; NM_001038186.2.
DR   AlphaFoldDB; Q2TA20; -.
DR   STRING; 9913.ENSBTAP00000020932; -.
DR   PaxDb; Q2TA20; -.
DR   PRIDE; Q2TA20; -.
DR   Ensembl; ENSBTAT00000020932; ENSBTAP00000020932; ENSBTAG00000015763.
DR   GeneID; 539692; -.
DR   KEGG; bta:539692; -.
DR   CTD; 84690; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015763; -.
DR   VGNC; VGNC:35180; SPATA22.
DR   eggNOG; ENOG502RNNP; Eukaryota.
DR   GeneTree; ENSGT00390000018151; -.
DR   InParanoid; Q2TA20; -.
DR   OMA; NIFRCVS; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000015763; Expressed in oocyte and 26 other tissues.
DR   ExpressionAtlas; Q2TA20; baseline.
DR   GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR   GO; GO:0007276; P:gamete generation; IEA:InterPro.
DR   GO; GO:0007129; P:homologous chromosome pairing at meiosis; IEA:InterPro.
DR   GO; GO:0000711; P:meiotic DNA repair synthesis; IEA:InterPro.
DR   GO; GO:0051445; P:regulation of meiotic cell cycle; IBA:GO_Central.
DR   InterPro; IPR033536; Spata22.
DR   PANTHER; PTHR35258; PTHR35258; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Meiosis; Reference proteome.
FT   CHAIN           1..364
FT                   /note="Spermatogenesis-associated protein 22"
FT                   /id="PRO_0000251604"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          70..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..46
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..117
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        118..132
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..189
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   364 AA;  41472 MW;  3D2FB59AD95F7623 CRC64;
     MKRNLNENST RSTAGCLPVP LFNQKKRNRQ PLTSNPCTND PGISNASDNY DFPPLPSDWA
     WEAVNPELPP LTKTVNTGQI PHSVSNSLRS QDSLSKPIQS NAGSSKSDWS YRDGNKNTSL
     KTWDKNDFKP QCKRRNLMTN NGINSGPINL GAQQQKQLRV SESTNLPNQR ESEALRQTKS
     SEIPGSTMRS LDKNSTLQAF KPNFQQNQFK KKMLDGFQEV NTLKKEASSY QLKLREKDNS
     LRIISAVIES MKYWREHVQK TVLLFEILAV LDSAVRPGPY CSKTFLMRDG KHTLPCVFYE
     IDRELPRLIR GRVHRCVGNY DQKKNIFKCV SVRPASASEQ KTFQAFVKIV DAEMRYYTSV
     MNEV