ID   SPT22_MACFA             Reviewed;         363 AA.
AC   Q95JQ1; Q9GM15;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Spermatogenesis-associated protein 22;
GN   Name=SPATA22; ORFNames=QnpA-20808, QtsA-14618;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Parietal cortex;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Meiosis-specific protein required for homologous
CC       recombination in meiosis I. {ECO:0000250|UniProtKB:Q5SV06}.
CC   -!- SUBUNIT: Component of a multiprotein complex with MEIOB and RPA2.
CC       Interacts with the complex BRME1:HSF2BP:BRCA2.
CC       {ECO:0000250|UniProtKB:Q5SV06}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q5SV06}.
CC       Note=Localizes on meiotic chromosome axes. Accumulates on resected DNA.
CC       Localization is dependent on MEIOB. {ECO:0000250|UniProtKB:Q5SV06}.
CC   -!- TISSUE SPECIFICITY: Expressed in testis.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB070129; BAB63074.1; -; mRNA.
DR   EMBL; AB050257; BAB17008.1; -; mRNA.
DR   RefSeq; NP_001270464.1; NM_001283535.1.
DR   AlphaFoldDB; Q95JQ1; -.
DR   STRING; 9541.XP_005582560.1; -.
DR   GeneID; 102135360; -.
DR   CTD; 84690; -.
DR   eggNOG; ENOG502RNNP; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR   GO; GO:0007276; P:gamete generation; IEA:InterPro.
DR   GO; GO:0007129; P:homologous chromosome pairing at meiosis; IEA:InterPro.
DR   GO; GO:0000711; P:meiotic DNA repair synthesis; IEA:InterPro.
DR   InterPro; IPR033536; Spata22.
DR   PANTHER; PTHR35258; PTHR35258; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Meiosis; Reference proteome.
FT   CHAIN           1..363
FT                   /note="Spermatogenesis-associated protein 22"
FT                   /id="PRO_0000251606"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          145..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..42
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        145..160
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        85
FT                   /note="P -> S (in Ref. 2; BAB17008)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        112
FT                   /note="S -> R (in Ref. 2; BAB17008)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        161
FT                   /note="P -> S (in Ref. 2; BAB17008)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        298
FT                   /note="F -> Y (in Ref. 2; BAB17008)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   363 AA;  41422 MW;  2AEAA7F09EA888D2 CRC64;
     MKRSLNENSA RSTAGCLPVP LFNQKKRNRQ PLTSNPLKDD PGISTPSDNY DFPPLPTDWA
     WEAMNAELAP VMKTVDTGQI PHSVPRPLRS QDSIFNSIQS NTERSQGGWS YSDNNKNTSL
     KTWNKNDFKP QCKRTNLVAN DGKNSCPMSS GAQQQKQFGI PEPPNLPRNK ETELLRQTHS
     SKISGSTMRG LDKNSALQTF KPNFQQNQYK KQMLDDIPED NTLKETSLFQ LQFKEKANSL
     RIISAVIESM KYWREHAQKT VLLFEVLAVL DSAVTPGPYY SKTFLMRDGK NTLPCVFFEI
     DRELPRLIRG RVHRCVGNYD QKKNIFKCVS VRPASVSEQK SFQAFVKIAD VEMRYYINVM
     NET