SPT25_HUMAN
ID SPT25_HUMAN Reviewed; 227 AA.
AC Q9BR10;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Spermatogenesis-associated protein 25;
DE AltName: Full=Testis-specific gene 23 protein;
GN Name=SPATA25; Synonyms=C20orf165, TSG23;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=19240080; DOI=10.1093/molehr/gap015;
RA Zhou Y., Qin D., Tang A., Zhou D., Qin J., Yan B., Diao R., Jiang Z.,
RA Cai Z., Gui Y.;
RT "Developmental expression pattern of a novel gene, TSG23/Tsg23, suggests a
RT role in spermatogenesis.";
RL Mol. Hum. Reprod. 15:223-230(2009).
CC -!- FUNCTION: May play a role in spermatogenesis.
CC {ECO:0000269|PubMed:19240080}.
CC -!- INTERACTION:
CC Q9BR10; Q08117-2: TLE5; NbExp=3; IntAct=EBI-12926726, EBI-11741437;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in testis (at protein
CC level). Expression is lower in patients with obstructive azoospermia
CC than in fertile controls and is not detected in patients with non-
CC obstructive azoospermia. {ECO:0000269|PubMed:19240080}.
CC -!- DEVELOPMENTAL STAGE: 60-fold stronger expression found in adult than
CC fetal testis. Detected in spermatocytes and round spermatids of the
CC seminiferous tubule. {ECO:0000269|PubMed:19240080}.
CC -!- SIMILARITY: Belongs to the SPATA25 family. {ECO:0000305}.
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DR EMBL; AL008726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC039607; AAH39607.1; -; mRNA.
DR CCDS; CCDS13383.1; -.
DR RefSeq; NP_542175.1; NM_080608.3.
DR AlphaFoldDB; Q9BR10; -.
DR BioGRID; 126127; 18.
DR IntAct; Q9BR10; 1.
DR STRING; 9606.ENSP00000361597; -.
DR BioMuta; SPATA25; -.
DR DMDM; 27805437; -.
DR MassIVE; Q9BR10; -.
DR PaxDb; Q9BR10; -.
DR PRIDE; Q9BR10; -.
DR Antibodypedia; 53799; 66 antibodies from 8 providers.
DR DNASU; 128497; -.
DR Ensembl; ENST00000372519.4; ENSP00000361597.3; ENSG00000149634.5.
DR GeneID; 128497; -.
DR KEGG; hsa:128497; -.
DR MANE-Select; ENST00000372519.4; ENSP00000361597.3; NM_080608.4; NP_542175.1.
DR UCSC; uc002xqf.4; human.
DR CTD; 128497; -.
DR DisGeNET; 128497; -.
DR GeneCards; SPATA25; -.
DR HGNC; HGNC:16158; SPATA25.
DR HPA; ENSG00000149634; Tissue enhanced (testis).
DR MIM; 618936; gene.
DR neXtProt; NX_Q9BR10; -.
DR OpenTargets; ENSG00000149634; -.
DR PharmGKB; PA25707; -.
DR VEuPathDB; HostDB:ENSG00000149634; -.
DR eggNOG; ENOG502SUEH; Eukaryota.
DR GeneTree; ENSGT00390000018626; -.
DR HOGENOM; CLU_120284_0_0_1; -.
DR InParanoid; Q9BR10; -.
DR OMA; GWEDGCS; -.
DR OrthoDB; 1378082at2759; -.
DR PhylomeDB; Q9BR10; -.
DR TreeFam; TF336974; -.
DR PathwayCommons; Q9BR10; -.
DR SignaLink; Q9BR10; -.
DR BioGRID-ORCS; 128497; 17 hits in 1074 CRISPR screens.
DR GenomeRNAi; 128497; -.
DR Pharos; Q9BR10; Tbio.
DR PRO; PR:Q9BR10; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9BR10; protein.
DR Bgee; ENSG00000149634; Expressed in left testis and 97 other tissues.
DR Genevisible; Q9BR10; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEP:UniProtKB.
DR InterPro; IPR029192; SPATA25.
DR PANTHER; PTHR36857; PTHR36857; 1.
DR Pfam; PF15218; SPATA25; 1.
PE 1: Evidence at protein level;
KW Differentiation; Membrane; Reference proteome; Spermatogenesis;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..227
FT /note="Spermatogenesis-associated protein 25"
FT /id="PRO_0000079478"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 94
FT /note="P -> L (in dbSNP:rs3827040)"
FT /id="VAR_015146"
SQ SEQUENCE 227 AA; 23834 MW; 938556AB1005C218 CRC64;
MSYFRTPQTH PGPLPSGQGG AASPGLSLGL CSPVEPVVVA SGGTGPLSQK AEQVAPAAQA
WGPALAMPQA RGCPGGTSWE TLRKEYSRNC HKFPHVRQLE SLGWDNGYSR SRAPDLGGPS
RPRPLMLCGL SPRVLPVPSE AVGKEASSQP DICILTLAMM IAGIPTVPVP GVREEDLIWA
AQAFMMAHPE PEGAVEGARW EQAHAHTASG KMPLVRSKRG QPPGSCL
