SPT25_MOUSE
ID SPT25_MOUSE Reviewed; 226 AA.
AC Q9DA57; A2A5J4; Q14B41;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Spermatogenesis-associated protein 25;
DE AltName: Full=Testis-specific gene 23 protein;
GN Name=Spata25; Synonyms=Tsg23;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROBABLE FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=19240080; DOI=10.1093/molehr/gap015;
RA Zhou Y., Qin D., Tang A., Zhou D., Qin J., Yan B., Diao R., Jiang Z.,
RA Cai Z., Gui Y.;
RT "Developmental expression pattern of a novel gene, TSG23/Tsg23, suggests a
RT role in spermatogenesis.";
RL Mol. Hum. Reprod. 15:223-230(2009).
CC -!- FUNCTION: May play a role in spermatogenesis.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed strongly in testis, weakly in epididymis
CC and not detected in other tissues. {ECO:0000269|PubMed:19240080}.
CC -!- DEVELOPMENTAL STAGE: Expression is detected at day 15 after birth and
CC gradually increases from day 15 to 5 months. Expression is found in
CC round spermatids with little expression in spermatogonia.
CC {ECO:0000269|PubMed:19240080}.
CC -!- SIMILARITY: Belongs to the SPATA25 family. {ECO:0000305}.
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DR EMBL; AK006145; BAB24430.1; -; mRNA.
DR EMBL; AL591495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC116355; AAI16356.1; -; mRNA.
DR CCDS; CCDS50799.1; -.
DR RefSeq; NP_083646.1; NM_029370.1.
DR AlphaFoldDB; Q9DA57; -.
DR STRING; 10090.ENSMUSP00000017911; -.
DR PaxDb; Q9DA57; -.
DR PRIDE; Q9DA57; -.
DR ProteomicsDB; 257388; -.
DR Antibodypedia; 53799; 66 antibodies from 8 providers.
DR Ensembl; ENSMUST00000017911; ENSMUSP00000017911; ENSMUSG00000017767.
DR GeneID; 75642; -.
DR KEGG; mmu:75642; -.
DR UCSC; uc008nwj.2; mouse.
DR CTD; 128497; -.
DR MGI; MGI:1922892; Spata25.
DR VEuPathDB; HostDB:ENSMUSG00000017767; -.
DR eggNOG; ENOG502SUEH; Eukaryota.
DR GeneTree; ENSGT00390000018626; -.
DR HOGENOM; CLU_120284_0_0_1; -.
DR InParanoid; Q9DA57; -.
DR OMA; GWEDGCS; -.
DR OrthoDB; 1378082at2759; -.
DR PhylomeDB; Q9DA57; -.
DR TreeFam; TF336974; -.
DR BioGRID-ORCS; 75642; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q9DA57; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9DA57; protein.
DR Bgee; ENSMUSG00000017767; Expressed in spermatid and 26 other tissues.
DR Genevisible; Q9DA57; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEP:UniProtKB.
DR InterPro; IPR029192; SPATA25.
DR PANTHER; PTHR36857; PTHR36857; 1.
DR Pfam; PF15218; SPATA25; 1.
PE 2: Evidence at transcript level;
KW Differentiation; Membrane; Reference proteome; Spermatogenesis;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..226
FT /note="Spermatogenesis-associated protein 25"
FT /id="PRO_0000079479"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 185
FT /note="F -> V (in Ref. 3; AAI16356)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 226 AA; 23548 MW; 22A0EFC6987A2622 CRC64;
MSYFVSPQSH LGLLPSGQGG AASSGSSLGL YSPAEPVVVA PGGLGPLSQK AEQVAPAAQA
WGPTLAVPEA RGCSGGVSWE TPRRKEHNRY CPKLPPMRPL ESLGWADPCS RSRAPYLGGP
SRPRPLLLCG LSPGVLPISS EAGGKEAASQ PDICILTLAM MIAGIPTVPV PGLREEDLIR
AAQAFMMAHP EPEGAVEGVQ WEQAHAHAHM ASGQMPLVRS RRGSCL
