ID   SPT45_HUMAN             Reviewed;          98 AA.
AC   Q537H7;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Spermatogenesis-associated protein 45;
GN   Name=SPATA45; Synonyms=C1orf227; ORFNames=HSD-44, HSD44;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RA   Wang Y., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.;
RT   "A new spermatogenesis-related gene.";
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the SPATA45 family. {ECO:0000305}.
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DR   EMBL; AY640234; AAU14247.1; -; mRNA.
DR   EMBL; AC104333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC035742; AAH35742.1; -; mRNA.
DR   CCDS; CCDS31020.1; -.
DR   RefSeq; NP_001019772.1; NM_001024601.2.
DR   AlphaFoldDB; Q537H7; -.
DR   SMR; Q537H7; -.
DR   STRING; 9606.ENSP00000419160; -.
DR   BioMuta; SPATA45; -.
DR   MassIVE; Q537H7; -.
DR   PaxDb; Q537H7; -.
DR   PeptideAtlas; Q537H7; -.
DR   PRIDE; Q537H7; -.
DR   Antibodypedia; 63752; 12 antibodies from 7 providers.
DR   DNASU; 149643; -.
DR   Ensembl; ENST00000332912.3; ENSP00000419160.1; ENSG00000185523.6.
DR   GeneID; 149643; -.
DR   KEGG; hsa:149643; -.
DR   MANE-Select; ENST00000332912.3; ENSP00000419160.1; NM_001024601.3; NP_001019772.1.
DR   UCSC; uc001hjq.4; human.
DR   CTD; 149643; -.
DR   GeneCards; SPATA45; -.
DR   HGNC; HGNC:33709; SPATA45.
DR   HPA; ENSG00000185523; Group enriched (pancreas, testis).
DR   neXtProt; NX_Q537H7; -.
DR   OpenTargets; ENSG00000185523; -.
DR   PharmGKB; PA164717042; -.
DR   VEuPathDB; HostDB:ENSG00000185523; -.
DR   eggNOG; ENOG502T16S; Eukaryota.
DR   GeneTree; ENSGT00390000018676; -.
DR   HOGENOM; CLU_182643_0_0_1; -.
DR   InParanoid; Q537H7; -.
DR   OMA; KRHFHGA; -.
DR   OrthoDB; 1525367at2759; -.
DR   PhylomeDB; Q537H7; -.
DR   TreeFam; TF338207; -.
DR   PathwayCommons; Q537H7; -.
DR   SignaLink; Q537H7; -.
DR   BioGRID-ORCS; 149643; 8 hits in 1010 CRISPR screens.
DR   GenomeRNAi; 149643; -.
DR   Pharos; Q537H7; Tdark.
DR   PRO; PR:Q537H7; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q537H7; protein.
DR   Bgee; ENSG00000185523; Expressed in right testis and 101 other tissues.
DR   Genevisible; Q537H7; HS.
DR   InterPro; IPR038806; SPATA45.
DR   PANTHER; PTHR35822; PTHR35822; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..98
FT                   /note="Spermatogenesis-associated protein 45"
FT                   /id="PRO_0000285785"
FT   VARIANT         8
FT                   /note="I -> T (in dbSNP:rs10864004)"
FT                   /id="VAR_060195"
SQ   SEQUENCE   98 AA;  11356 MW;  5D38BBBA9B5BE730 CRC64;
     MASINRTIEI MKKHGVSKQH LLEEINKKRE SNCLVERSNQ VSLLRVQKRH FPDAYQSFTD
     TTTKEPVPNS GRSSWIKLSL LAHMERKHFP PKNNAIFG