ID   SPT46_BOVIN             Reviewed;         247 AA.
AC   Q2YDE2;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Spermatogenesis-associated protein 46;
GN   Name=SPATA46;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in spermiogenesis and fertilization.
CC       {ECO:0000250|UniProtKB:Q4FZF2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q4FZF2}.
CC       Note=Located throughout the subacrosomal area.
CC       {ECO:0000250|UniProtKB:Q4FZF2}.
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DR   EMBL; BC110262; AAI10263.1; -; mRNA.
DR   RefSeq; NP_001039925.1; NM_001046460.2.
DR   AlphaFoldDB; Q2YDE2; -.
DR   STRING; 9913.ENSBTAP00000013422; -.
DR   PaxDb; Q2YDE2; -.
DR   PRIDE; Q2YDE2; -.
DR   Ensembl; ENSBTAT00000013422; ENSBTAP00000013422; ENSBTAG00000010174.
DR   GeneID; 539685; -.
DR   KEGG; bta:539685; -.
DR   CTD; 284680; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010174; -.
DR   VGNC; VGNC:35186; SPATA46.
DR   eggNOG; ENOG502S3KA; Eukaryota.
DR   GeneTree; ENSGT00390000007598; -.
DR   HOGENOM; CLU_073753_0_0_1; -.
DR   InParanoid; Q2YDE2; -.
DR   OMA; GSCQAFN; -.
DR   OrthoDB; 1142827at2759; -.
DR   TreeFam; TF337124; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000010174; Expressed in semen and 60 other tissues.
DR   GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0009566; P:fertilization; IBA:GO_Central.
DR   GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR   InterPro; IPR040879; Spt46-like.
DR   PANTHER; PTHR33517; PTHR33517; 1.
DR   Pfam; PF17734; Spt46; 1.
PE   2: Evidence at transcript level;
KW   Differentiation; Membrane; Nucleus; Reference proteome; Spermatogenesis.
FT   CHAIN           1..247
FT                   /note="Spermatogenesis-associated protein 46"
FT                   /id="PRO_0000279457"
FT   REGION          125..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..150
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   247 AA;  27521 MW;  64900995A8839108 CRC64;
     MENFSLLSIS GTRISSSALS TLPDIMSSRA TSLPDIAKPV LPTEVPSPVQ ALPPQCPGGV
     LRHGVHNIVI SPDCILGDAP NGEQLRWNCT IYRPWFSPYS YFLCKDKESH LETYSFSEVQ
     RDEGQRDSCL PEDTADSVCS SSPSPENTCP REATKKSRPG PDTTDSITFQ DILMASKWHP
     AQQNGYKCAS CCRLYPTLHS LKSHIKRGFK EGFSCKVYYH KLKTLWYKEQ KARPGDRLSL
     GSGQAFR