ID   SPT46_MACFA             Reviewed;         251 AA.
AC   Q4R7L6;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 29.
DE   RecName: Full=Spermatogenesis-associated protein 46;
GN   Name=SPATA46; ORFNames=QtsA-14887;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in spermiogenesis and fertilization.
CC       {ECO:0000250|UniProtKB:Q4FZF2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q4FZF2}.
CC       Note=Located throughout the subacrosomal area.
CC       {ECO:0000250|UniProtKB:Q4FZF2}.
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DR   EMBL; AB168799; BAE00906.1; -; mRNA.
DR   AlphaFoldDB; Q4R7L6; -.
DR   Ensembl; ENSMFAT00000017903; ENSMFAP00000043613; ENSMFAG00000039214.
DR   GeneTree; ENSGT00390000007598; -.
DR   Proteomes; UP000233100; Chromosome 1.
DR   Bgee; ENSMFAG00000039214; Expressed in multicellular organism and 2 other tissues.
DR   GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR   InterPro; IPR040879; Spt46-like.
DR   PANTHER; PTHR33517; PTHR33517; 1.
DR   Pfam; PF17734; Spt46; 1.
PE   2: Evidence at transcript level;
KW   Differentiation; Membrane; Nucleus; Reference proteome; Spermatogenesis.
FT   CHAIN           1..251
FT                   /note="Spermatogenesis-associated protein 46"
FT                   /id="PRO_0000279459"
SQ   SEQUENCE   251 AA;  28000 MW;  10DCA91969E58EF3 CRC64;
     MENFSLLSIS GPPISSSALS AFPDIMFSRA TSLPDIAKTA VPTEASSPAQ ALPPQYQSIT
     VRQGIQNTAL SPDCSLGDTQ HGEKLRRNCT IYRPWFSPYS YFVCADKESH PEAYDFPEVQ
     QDEGKWDNCL SEDMAESICS SSSSAENTCP REATKKSRHG LDSITSQDIL MASRWHPAQQ
     NGYKCAACCR MYPTLDFLKS HIKRGFREGF SCKVYYRKLK ALWSKEPKAW LGDRLSSGSC
     QAFNSPAEHL R