ID   SPT46_MOUSE             Reviewed;         204 AA.
AC   Q4FZF2;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Spermatogenesis-associated protein 46 {ECO:0000303|PubMed:27488028};
GN   Name=Spata46;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE, AND
RP   FUNCTION.
RX   PubMed=27488028; DOI=10.1095/biolreprod.116.140996;
RA   Chen J., Gu Y., Zhang Z., Zheng W., Yang L., Huang W., Lin S., Li Y.,
RA   Guo H., Luo M., Ma Q., Jiang Z., Tang A., Gui Y.;
RT   "Deficiency of SPATA46, a novel nuclear membrane protein, causes
RT   subfertility in male mice.";
RL   Biol. Reprod. 95:58-58(2016).
CC   -!- FUNCTION: Plays a role in spermiogenesis and fertilization.
CC       {ECO:0000269|PubMed:27488028}.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:27488028}.
CC       Note=Located throughout the subacrosomal area (PubMed:27488028).
CC       {ECO:0000269|PubMed:27488028}.
CC   -!- TISSUE SPECIFICITY: Testis-specific (PubMed:27488028).
CC       {ECO:0000269|PubMed:27488028}.
CC   -!- DEVELOPMENTAL STAGE: Increases in the third week postnatal and
CC       gradually increased until the adult stage (PubMed:27488028).
CC       {ECO:0000269|PubMed:27488028}.
CC   -!- DISRUPTION PHENOTYPE: Deficient mice develop and grow normally.
CC       Knockout males, but not females, exhibit subfertile capacity. Deficient
CC       mice are characterized by abnormal sperm head shape and a failure of
CC       sperm-egg fusion (PubMed:27488028). {ECO:0000269|PubMed:27488028}.
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DR   EMBL; BC099563; AAH99563.1; -; mRNA.
DR   EMBL; BC132313; AAI32314.1; -; mRNA.
DR   EMBL; BC132315; AAI32316.1; -; mRNA.
DR   CCDS; CCDS15471.1; -.
DR   RefSeq; NP_001034682.1; NM_001039593.1.
DR   AlphaFoldDB; Q4FZF2; -.
DR   STRING; 10090.ENSMUSP00000062245; -.
DR   iPTMnet; Q4FZF2; -.
DR   PhosphoSitePlus; Q4FZF2; -.
DR   PaxDb; Q4FZF2; -.
DR   PRIDE; Q4FZF2; -.
DR   ProteomicsDB; 257391; -.
DR   Antibodypedia; 34319; 171 antibodies from 17 providers.
DR   Ensembl; ENSMUST00000056991; ENSMUSP00000062245; ENSMUSG00000042800.
DR   GeneID; 76925; -.
DR   KEGG; mmu:76925; -.
DR   UCSC; uc007dmd.1; mouse.
DR   CTD; 284680; -.
DR   MGI; MGI:1924175; Spata46.
DR   VEuPathDB; HostDB:ENSMUSG00000042800; -.
DR   eggNOG; ENOG502S3KA; Eukaryota.
DR   GeneTree; ENSGT00390000007598; -.
DR   HOGENOM; CLU_073753_0_0_1; -.
DR   InParanoid; Q4FZF2; -.
DR   OMA; GSCQAFN; -.
DR   OrthoDB; 1142827at2759; -.
DR   PhylomeDB; Q4FZF2; -.
DR   TreeFam; TF337124; -.
DR   BioGRID-ORCS; 76925; 2 hits in 72 CRISPR screens.
DR   PRO; PR:Q4FZF2; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; Q4FZF2; protein.
DR   Bgee; ENSMUSG00000042800; Expressed in seminiferous tubule of testis and 38 other tissues.
DR   Genevisible; Q4FZF2; MM.
DR   GO; GO:0031965; C:nuclear membrane; IMP:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0009566; P:fertilization; IBA:GO_Central.
DR   GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; IMP:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; IMP:UniProtKB.
DR   InterPro; IPR040879; Spt46-like.
DR   PANTHER; PTHR33517; PTHR33517; 2.
DR   Pfam; PF17734; Spt46; 2.
PE   2: Evidence at transcript level;
KW   Differentiation; Membrane; Nucleus; Reference proteome; Spermatogenesis.
FT   CHAIN           1..204
FT                   /note="Spermatogenesis-associated protein 46"
FT                   /id="PRO_0000279460"
FT   REGION          101..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   204 AA;  22997 MW;  40CC3B2F288ED90B CRC64;
     MDNYSLLSTP RPRISSSALS AFPDIMSSLA TSLPDLGDTQ NGEQLRRNCT IYRPWFSPYS
     YFVCTDKESH LEAYGFPEVD REEGRGDNCL LEDVAESVCS SSSSQENTYP REANRKSKHG
     LDSITSQDIL MASKWHPAQQ NGYKCASCCR MYPTLHSLKS HIKGGFKEGF SCKVYYRKLK
     TLWGKEQKAR TGDRISLGSC QAFK