ID   SPT4H_XENLA             Reviewed;         117 AA.
AC   Q5HZ97;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Transcription elongation factor SPT4;
DE   AltName: Full=DRB sensitivity-inducing factor small subunit;
DE            Short=DSIF small subunit;
GN   Name=supt4h1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a component of the DRB sensitivity-inducing
CC       factor complex (DSIF complex), which regulates transcription elongation
CC       by RNA polymerase II. Probably enhances transcriptional pausing at
CC       sites proximal to the promoter, which may in turn facilitate the
CC       assembly of an elongation competent RNA polymerase II complex (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SUPT5H to form the DSIF complex. DSIF interacts
CC       with RNA polymerase II and with the positive transcription elongation
CC       factor b complex (P-TEFb complex), which is composed of CDK9 and
CC       cyclin-T (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPT4 family. {ECO:0000305}.
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DR   EMBL; BC089123; AAH89123.1; -; mRNA.
DR   RefSeq; NP_001089206.1; NM_001095737.1.
DR   RefSeq; XP_018104551.1; XM_018249062.1.
DR   AlphaFoldDB; Q5HZ97; -.
DR   SMR; Q5HZ97; -.
DR   MaxQB; Q5HZ97; -.
DR   DNASU; 734253; -.
DR   GeneID; 108709324; -.
DR   GeneID; 734253; -.
DR   KEGG; xla:108709324; -.
DR   KEGG; xla:734253; -.
DR   CTD; 108709324; -.
DR   CTD; 734253; -.
DR   Xenbase; XB-GENE-977396; supt4h1.L.
DR   Xenbase; XB-GENE-17343285; supt4h1.S.
DR   OMA; EIHEVDS; -.
DR   OrthoDB; 1617752at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 108709324; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0032044; C:DSIF complex; ISS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0032786; P:positive regulation of DNA-templated transcription, elongation; IEA:InterPro.
DR   CDD; cd07973; Spt4; 1.
DR   Gene3D; 3.30.40.210; -; 1.
DR   InterPro; IPR029040; RPABC4/Spt4.
DR   InterPro; IPR009287; Spt4.
DR   InterPro; IPR022800; Spt4/RpoE2_Znf.
DR   InterPro; IPR038510; Spt4_sf.
DR   PANTHER; PTHR12882; PTHR12882; 1.
DR   Pfam; PF06093; Spt4; 1.
DR   PIRSF; PIRSF025023; Spt4; 1.
DR   SMART; SM01389; Spt4; 1.
DR   SUPFAM; SSF63393; SSF63393; 1.
PE   3: Inferred from homology;
KW   Activator; Metal-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..117
FT                   /note="Transcription elongation factor SPT4"
FT                   /id="PRO_0000210331"
FT   ZN_FING         16..36
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255"
FT   REGION          1..40
FT                   /note="Interaction with SUPT5H"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   117 AA;  13221 MW;  79012AC694717F07 CRC64;
     MALETVPKDL RHLRACLLCS LVKTIDQFEY DGCDNCDAYL QMKGNREMVY DCTSSSFDGI
     VAMMSPDDSW VSKWQRITNF KPGVYAVSVT GRLPQGIVRE LKSRGVVYKS RDTAIKT