SPT4_ASHGO
ID SPT4_ASHGO Reviewed; 102 AA.
AC Q752J8;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Transcription elongation factor SPT4;
DE AltName: Full=Chromatin elongation factor SPT4;
GN Name=SPT4; OrderedLocusNames=AFR576C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: The SPT4-SPT5 complex mediates both activation and inhibition
CC of transcription elongation, and plays a role in pre-mRNA processing.
CC This complex seems to be important for the stability of the RNA
CC polymerase II elongation machinery on the chromatin template but not
CC for the inherent ability of this machinery to translocate down the gene
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the SPT4-SPT5 complex. Interacts with RNA
CC polymerase II (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere {ECO:0000250}.
CC Note=Centromere and heterochromatin. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SPT4 family. {ECO:0000305}.
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DR EMBL; AE016819; AAS53947.1; -; Genomic_DNA.
DR RefSeq; NP_986123.1; NM_212259.1.
DR AlphaFoldDB; Q752J8; -.
DR SMR; Q752J8; -.
DR STRING; 33169.AAS53947; -.
DR EnsemblFungi; AAS53947; AAS53947; AGOS_AFR576C.
DR GeneID; 4622405; -.
DR KEGG; ago:AGOS_AFR576C; -.
DR eggNOG; KOG3490; Eukaryota.
DR HOGENOM; CLU_138052_2_1_1; -.
DR InParanoid; Q752J8; -.
DR OMA; FDGMIAV; -.
DR Proteomes; UP000000591; Chromosome VI.
DR GO; GO:0032044; C:DSIF complex; IBA:GO_Central.
DR GO; GO:0000776; C:kinetochore; IEA:EnsemblFungi.
DR GO; GO:0031934; C:mating-type region heterochromatin; IEA:EnsemblFungi.
DR GO; GO:0033553; C:rDNA heterochromatin; IEA:EnsemblFungi.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:EnsemblFungi.
DR GO; GO:0000182; F:rDNA binding; IEA:EnsemblFungi.
DR GO; GO:0000993; F:RNA polymerase II complex binding; IBA:GO_Central.
DR GO; GO:0003727; F:single-stranded RNA binding; IEA:EnsemblFungi.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006370; P:7-methylguanosine mRNA capping; IEA:EnsemblFungi.
DR GO; GO:0006325; P:chromatin organization; IBA:GO_Central.
DR GO; GO:0031507; P:heterochromatin assembly; IEA:EnsemblFungi.
DR GO; GO:0008298; P:intracellular mRNA localization; IEA:EnsemblFungi.
DR GO; GO:0006397; P:mRNA processing; IBA:GO_Central.
DR GO; GO:0010507; P:negative regulation of autophagy; IEA:EnsemblFungi.
DR GO; GO:2001208; P:negative regulation of transcription elongation by RNA polymerase I; IEA:EnsemblFungi.
DR GO; GO:2001209; P:positive regulation of transcription elongation from RNA polymerase I promoter; IEA:EnsemblFungi.
DR GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR GO; GO:2000232; P:regulation of rRNA processing; IEA:EnsemblFungi.
DR GO; GO:0034243; P:regulation of transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR GO; GO:0090262; P:regulation of transcription-coupled nucleotide-excision repair; IEA:EnsemblFungi.
DR CDD; cd07973; Spt4; 1.
DR Gene3D; 3.30.40.210; -; 1.
DR InterPro; IPR029040; RPABC4/Spt4.
DR InterPro; IPR009287; Spt4.
DR InterPro; IPR022800; Spt4/RpoE2_Znf.
DR InterPro; IPR038510; Spt4_sf.
DR PANTHER; PTHR12882; PTHR12882; 1.
DR Pfam; PF06093; Spt4; 1.
DR PIRSF; PIRSF025023; Spt4; 1.
DR SMART; SM01389; Spt4; 1.
DR SUPFAM; SSF63393; SSF63393; 1.
PE 3: Inferred from homology;
KW Centromere; Chromosome; Metal-binding; mRNA processing; Nucleus;
KW Reference proteome; Transcription; Zinc; Zinc-finger.
FT CHAIN 1..102
FT /note="Transcription elongation factor SPT4"
FT /id="PRO_0000238545"
FT ZN_FING 7..27
FT /note="C4-type"
FT /evidence="ECO:0000255"
SQ SEQUENCE 102 AA; 11206 MW; 048E883A3FFBF3BB CRC64;
MSSDRACMLC GIVQTTNEFT RDGCPNCQGI FEEASVSAIE CTSPSFEGLV GMCKPTKSWV
AKWISVEQYV PGMYAIKVDG RLPVEVVDLL PHYKPRDGSQ VD
