ID   SPT5_ACIAM              Reviewed;         152 AA.
AC   Q46494;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Transcription elongation factor Spt5 {ECO:0000255|HAMAP-Rule:MF_00950};
GN   Name=spt5 {ECO:0000255|HAMAP-Rule:MF_00950};
OS   Acidianus ambivalens (Desulfurolobus ambivalens).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Acidianus.
OX   NCBI_TaxID=2283;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Lei 10 / DSM 3772 / JCM 9191;
RX   PubMed=9133659; DOI=10.1016/s0304-4165(96)00141-9;
RA   Moll R., Schmidtke S., Petersen A., Schaefer G.;
RT   "The signal recognition particle receptor alpha subunit of the
RT   hyperthermophilic archaeon Acidianus ambivalens exhibits an intrinsic GTP-
RT   hydrolyzing activity.";
RL   Biochim. Biophys. Acta 1335:218-230(1997).
CC   -!- FUNCTION: Stimulates transcription elongation. {ECO:0000255|HAMAP-
CC       Rule:MF_00950}.
CC   -!- SUBUNIT: Heterodimer composed of Spt4 and Spt5. Interacts with RNA
CC       polymerase (RNAP). {ECO:0000255|HAMAP-Rule:MF_00950}.
CC   -!- SIMILARITY: Belongs to the archaeal Spt5 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00950}.
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DR   EMBL; X95989; CAA65235.1; -; Genomic_DNA.
DR   PIR; T48924; T48924.
DR   AlphaFoldDB; Q46494; -.
DR   SMR; Q46494; -.
DR   GO; GO:0005840; C:ribosome; IEA:InterPro.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 3.30.70.940; -; 1.
DR   HAMAP; MF_00950; Spt5_arch; 1.
DR   InterPro; IPR005824; KOW.
DR   InterPro; IPR005100; NGN-domain.
DR   InterPro; IPR006645; NGN_dom.
DR   InterPro; IPR036735; NGN_dom_sf.
DR   InterPro; IPR014722; Rib_L2_dom2.
DR   InterPro; IPR005825; Ribosomal_L24/26_CS.
DR   InterPro; IPR011590; Spt5_arc.
DR   InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR   Pfam; PF00467; KOW; 1.
DR   Pfam; PF03439; Spt5-NGN; 1.
DR   SMART; SM00739; KOW; 1.
DR   SMART; SM00738; NGN; 1.
DR   SUPFAM; SSF50104; SSF50104; 1.
DR   TIGRFAMs; TIGR00405; KOW_elon_Spt5; 1.
PE   3: Inferred from homology;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..152
FT                   /note="Transcription elongation factor Spt5"
FT                   /id="PRO_0000113976"
FT   DOMAIN          98..127
FT                   /note="KOW"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00950"
SQ   SEQUENCE   152 AA;  16417 MW;  8C84E89C96C8CF64 CRC64;
     MESKIRNYYA VKVTGGQEVS VGLMLEERAK TNNIPEIYSI IVPPGLKGYV IVEASGPHVV
     KLLIAGIRHV RGIAQGLVPK DHIVKMVSKK VTGPTIKEGD LVEVVSGPFR GMQAQVVKVT
     EGKGEVVLNI LESAFPLQVT IPVDQVKPVK KT