ID   SPT5_AERPE              Reviewed;         151 AA.
AC   Q9Y9W3;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 2.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Transcription elongation factor Spt5 {ECO:0000255|HAMAP-Rule:MF_00950};
GN   Name=spt5 {ECO:0000255|HAMAP-Rule:MF_00950}; OrderedLocusNames=APE_2176.1;
OS   Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS   K1).
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=272557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX   PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA   Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA   Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA   Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT   "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT   Aeropyrum pernix K1.";
RL   DNA Res. 6:83-101(1999).
CC   -!- FUNCTION: Stimulates transcription elongation. {ECO:0000255|HAMAP-
CC       Rule:MF_00950}.
CC   -!- SUBUNIT: Heterodimer composed of Spt4 and Spt5. Interacts with RNA
CC       polymerase (RNAP). {ECO:0000255|HAMAP-Rule:MF_00950}.
CC   -!- SIMILARITY: Belongs to the archaeal Spt5 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00950}.
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DR   EMBL; BA000002; BAA81187.2; -; Genomic_DNA.
DR   PIR; C72525; C72525.
DR   AlphaFoldDB; Q9Y9W3; -.
DR   SMR; Q9Y9W3; -.
DR   STRING; 272557.APE_2176.1; -.
DR   EnsemblBacteria; BAA81187; BAA81187; APE_2176.1.
DR   KEGG; ape:APE_2176.1; -.
DR   eggNOG; arCOG01920; Archaea.
DR   Proteomes; UP000002518; Chromosome.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 3.30.70.940; -; 1.
DR   HAMAP; MF_00950; Spt5_arch; 1.
DR   InterPro; IPR005824; KOW.
DR   InterPro; IPR005100; NGN-domain.
DR   InterPro; IPR006645; NGN_dom.
DR   InterPro; IPR036735; NGN_dom_sf.
DR   InterPro; IPR014722; Rib_L2_dom2.
DR   InterPro; IPR011590; Spt5_arc.
DR   InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR   Pfam; PF00467; KOW; 1.
DR   Pfam; PF03439; Spt5-NGN; 1.
DR   SMART; SM00739; KOW; 1.
DR   SMART; SM00738; NGN; 1.
DR   SUPFAM; SSF50104; SSF50104; 1.
DR   TIGRFAMs; TIGR00405; KOW_elon_Spt5; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..151
FT                   /note="Transcription elongation factor Spt5"
FT                   /id="PRO_0000113977"
FT   DOMAIN          98..128
FT                   /note="KOW"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00950"
SQ   SEQUENCE   151 AA;  16589 MW;  8CFE8AFB3622E999 CRC64;
     MEGGVDARFY AILVTSGAEV NVATIIAERA RALGLDIRSI IVPPRIKGYV ILEAHDPGDV
     YDATRGLRHV KRRRPLILKF EEVMKLVKPE VEIPALKPGQ VVEIVAGAFK GMKARVIDVN
     QSKGQVTVSL LEPLFRATAT IPIDEVRPVE E