SPT5_ASPFU
ID SPT5_ASPFU Reviewed; 1058 AA.
AC Q4WP96;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Transcription elongation factor spt5;
DE AltName: Full=Chromatin elongation factor spt5;
GN Name=spt5; ORFNames=AFUA_4G08500;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: The spt4-spt5 complex mediates both activation and inhibition
CC of transcription elongation, and plays a role in pre-mRNA processing.
CC This complex seems to be important for the stability of the RNA
CC polymerase II elongation machinery on the chromatin template but not
CC for the inherent ability of this machinery to translocate down the gene
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the spt4-spt5 complex. Interacts with RNA
CC polymerase II (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SPT5 family. {ECO:0000305}.
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DR EMBL; AAHF01000005; EAL89938.1; -; Genomic_DNA.
DR RefSeq; XP_751976.1; XM_746883.1.
DR AlphaFoldDB; Q4WP96; -.
DR SMR; Q4WP96; -.
DR STRING; 746128.CADAFUBP00006385; -.
DR EnsemblFungi; EAL89938; EAL89938; AFUA_4G08500.
DR GeneID; 3509235; -.
DR KEGG; afm:AFUA_4G08500; -.
DR VEuPathDB; FungiDB:Afu4g08500; -.
DR eggNOG; KOG1999; Eukaryota.
DR HOGENOM; CLU_003537_1_1_1; -.
DR InParanoid; Q4WP96; -.
DR OMA; VGYMNTP; -.
DR OrthoDB; 828863at2759; -.
DR Proteomes; UP000002530; Chromosome 4.
DR GO; GO:0032044; C:DSIF complex; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0060195; P:negative regulation of antisense RNA transcription; IEA:EnsemblFungi.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0034243; P:regulation of transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR CDD; cd06081; KOW_Spt5_1; 1.
DR CDD; cd06082; KOW_Spt5_2; 1.
DR CDD; cd06083; KOW_Spt5_3; 1.
DR CDD; cd06084; KOW_Spt5_4; 1.
DR CDD; cd06085; KOW_Spt5_5; 1.
DR CDD; cd09888; NGN_Euk; 1.
DR Gene3D; 2.30.30.30; -; 4.
DR Gene3D; 3.30.70.940; -; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041975; KOW_Spt5_2.
DR InterPro; IPR041976; KOW_Spt5_3.
DR InterPro; IPR041977; KOW_Spt5_4.
DR InterPro; IPR041978; KOW_Spt5_5.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR006645; NGN_dom.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_L2_dom2.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR024945; Spt5_C_dom.
DR InterPro; IPR022581; Spt5_N.
DR InterPro; IPR017071; TF_Spt5_eukaryote.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; PTHR11125; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR Pfam; PF11942; Spt5_N; 1.
DR PIRSF; PIRSF036945; Spt5; 1.
DR SMART; SM01104; CTD; 1.
DR SMART; SM00739; KOW; 5.
DR SMART; SM00738; NGN; 1.
DR SUPFAM; SSF50104; SSF50104; 1.
PE 3: Inferred from homology;
KW mRNA processing; Nucleus; Reference proteome; Transcription.
FT CHAIN 1..1058
FT /note="Transcription elongation factor spt5"
FT /id="PRO_0000238555"
FT REGION 1..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 818..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..1058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..25
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..124
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..170
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..896
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..962
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1058 AA; 114171 MW; E8E259430A7A8288 CRC64;
MSRNFLNEDF GSEEEDDDFN PAPAEDSDEE DVKPQSTSRG RINEEEEDDD HADVKPERAD
REGSEDDVKE DIDADEADAG GERDEGEDEE EGENDEDDED DEEEGEEEEE DEDDEDEDED
EDEQDVSSGR PRKRRKRLGG VHNFIDTEAG VDEEEDEAED EEDEMEFGAE MHPDDLDALP
AGADTDDRRH RQLDRQRELE ASMDAEKQAQ LLKERYGRNR AAATDAVVVP KRLLLPSVDD
PSIWGVRCKA GKEREVVFAI QKRIEERPPG SRKPIRIISA FERGGAMSGY IYVEARRQAD
VMEALEDMSN VYPRTKMILV PVREMPDLLR VQKSEELNPG GWVRIKRGKY QGDLAQIEEV
DTNGLDVTVR LVPRLDYGLN EDSGAPVVDI KRKRPGMASG GPRPPQRLFS EAEAKKRHGK
YLSATSGLGG KSWSYLGETY IDGFLIKDMK VQHLITKNVN PRLEEVTMFA RGSDDGTSNL
DLASLAETLK NSTAEESYLP GDPVEVFRGE QQGLVGRTTS TRGDIVTLQV TEGELAGQMI
EAPVKSLRKR FREGDHVKVI GGSRYQDELG MVVQVKDDTV TLLSDMSMQE ITVFSKDLRL
SAETGVDGKL GMFDVHDLVQ LDASTVACVV KVDRESLRVL DQNGSIRTVL PSQIANKITP
RRDAVATDRN GAEIRIGDTV RELYGDQRSG VILHIYRSFL FLHNKAQAEN SGIVVVRTTN
VVTVSAKGGR STGPDLTKMN PALMRSGIPG ASMGPPKSFG HDRLIGKTVQ VRKGPYKGLV
GIVKDSTDVQ ARVELHSRNK LVTIPKDVLI VKDPVTGQTL DMSRKGGQRV PYGASAAPPS
GWSGGRTPMA AADSSRTPAW GGASSARTPA WAGISGSRTP AWKMDGSRTS NPYDGSRTAY
GGAGSRTPAW NAGARTPYDS GSGSSGFDAF AAGSRTPAWG GANAGGRTPA WSASSSAGSG
NRDSRGYDAP NPGGAYSAPT PGAYTAPTPG ASAPTPGAWA DSAPTPGVFN APTPGGLSGR
PYDAPTPAMG GAAATPGAGA YGDGEDGGPR YDEGTPSP
