SPT5_ASPOR
ID SPT5_ASPOR Reviewed; 1026 AA.
AC Q2UGU3;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Transcription elongation factor spt5;
DE AltName: Full=Chromatin elongation factor spt5;
GN Name=spt5; ORFNames=AO090023000710;
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- FUNCTION: The spt4-spt5 complex mediates both activation and inhibition
CC of transcription elongation, and plays a role in pre-mRNA processing.
CC This complex seems to be important for the stability of the RNA
CC polymerase II elongation machinery on the chromatin template but not
CC for the inherent ability of this machinery to translocate down the gene
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the spt4-spt5 complex. Interacts with RNA
CC polymerase II (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SPT5 family. {ECO:0000305}.
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DR EMBL; AP007157; BAE59222.1; -; Genomic_DNA.
DR RefSeq; XP_001821224.1; XM_001821172.1.
DR AlphaFoldDB; Q2UGU3; -.
DR SMR; Q2UGU3; -.
DR STRING; 510516.Q2UGU3; -.
DR EnsemblFungi; BAE59222; BAE59222; AO090023000710.
DR GeneID; 5993226; -.
DR KEGG; aor:AO090023000710; -.
DR VEuPathDB; FungiDB:AO090023000710; -.
DR HOGENOM; CLU_003537_1_1_1; -.
DR OMA; VGYMNTP; -.
DR Proteomes; UP000006564; Chromosome 3.
DR GO; GO:0032044; C:DSIF complex; IEA:EnsemblFungi.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0060195; P:negative regulation of antisense RNA transcription; IEA:EnsemblFungi.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0034243; P:regulation of transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR CDD; cd06081; KOW_Spt5_1; 1.
DR CDD; cd06082; KOW_Spt5_2; 1.
DR CDD; cd06083; KOW_Spt5_3; 1.
DR CDD; cd06084; KOW_Spt5_4; 1.
DR CDD; cd06085; KOW_Spt5_5; 1.
DR CDD; cd09888; NGN_Euk; 1.
DR Gene3D; 2.30.30.30; -; 3.
DR Gene3D; 3.30.70.940; -; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041975; KOW_Spt5_2.
DR InterPro; IPR041976; KOW_Spt5_3.
DR InterPro; IPR041977; KOW_Spt5_4.
DR InterPro; IPR041978; KOW_Spt5_5.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR006645; NGN_dom.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_L2_dom2.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR024945; Spt5_C_dom.
DR InterPro; IPR022581; Spt5_N.
DR InterPro; IPR017071; TF_Spt5_eukaryote.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; PTHR11125; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR Pfam; PF11942; Spt5_N; 1.
DR PIRSF; PIRSF036945; Spt5; 1.
DR SMART; SM01104; CTD; 1.
DR SMART; SM00739; KOW; 5.
DR SMART; SM00738; NGN; 1.
DR SUPFAM; SSF50104; SSF50104; 1.
PE 3: Inferred from homology;
KW mRNA processing; Nucleus; Reference proteome; Repeat; Transcription.
FT CHAIN 1..1026
FT /note="Transcription elongation factor spt5"
FT /id="PRO_0000238556"
FT DOMAIN 305..338
FT /note="KOW 1"
FT DOMAIN 519..553
FT /note="KOW 2"
FT REGION 1..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 788..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 905..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..93
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..136
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 905..930
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1026 AA; 111285 MW; 646958E269E2E583 CRC64;
MSRNMLDHDF GSDEEDDDFN PAPAYDSDNE DARPTHQDRD DDDDEEDVKP SRRAERRVGS
EEADDNEDAD GHDDEEEDEN DDDDEEEEDE DEEGAVSRPK KRRRKGGVAH FFEEEAGVDE
DEDEAEDEED EMAELGGEMH PDDMDALPVG AETDDRRHRQ LDRQRELEAS MDAEKQAQLL
KERYGRNRAA ASDAVVVPKR LLLPSVEDPS IWGVRCKPGK EREVIFAIQK RIEERPMGSR
NPMKIISAFE RGGAMSGYIY VEARRQADVM DALQDMSNVY PRTKMILVPV REMPDLLRVQ
KSEELLPGGW VRIKRGKYQN DLAQIEEVET NGLAVTVRLV PRLDYGMNED IGAPFMDPKR
KRPGMNPAVA RPPQRLFSEA EAKKKHGKYL SATSGLGGKS WSYLGETYVD GFLIKDMKVQ
HLITKNVSPR LEEVTMFARG SEDGTANLDL ASLAETLKNS TAEDSYLPGD PVEVFRGEQQ
GLIGRTTSTR GDIVTLQVTE GDLAGQHIDA PVKSLRKRFR EGDHVKVIGG SRYQDELGMV
VQVKDDTVTL LSDMSMQEIT VFSKDLRLSA ETGVDGKLGM FDVHDLVQLD AATVACIVKV
DRESLRVLDQ NGSIRTILPT QVTNKITPRR DAVATDRNGA EIRHGDTVRE VYGEQRNGVI
LHIHRSFLFL HNKAQAENSG ITVVRTTNVV TVSAKGGRST GPDLTKMNPA LMSRGGPSGM
MGPPKSFGRD RMIGKTVMVR KGPFKGLVGI VKDAGDVQAR VELHSKNKLV SIPKELLVVK
DPVTGQTIEM GRGRGGPRVP SAAPPSGWQG GRTPMAAADS SRTPAWGGAS SARTPAWAGM
GGSRTPAWKN DGSRTSNPYD GSRTAYGGFG SRTPAWNAGA RTPYGGSGSG QSDFDAFAAG
SRTPAWNANS GSRTPAWSGA TASNGSKDSR GYDAPTPGGA YSAPTPGAYA SAPTPGVSAP
TPGAWADSAP TPGAFNAPTP GGPSKKPYDA PTPAAWDSRP YDAPTPAMGG DGDDAGPRYE
DGTPSP
