SPT5_CRYNB
ID SPT5_CRYNB Reviewed; 1152 AA.
AC P0CR71; Q55Z86; Q5KNK1;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 44.
DE RecName: Full=Transcription elongation factor SPT5;
DE AltName: Full=Chromatin elongation factor SPT5;
GN Name=SPT5; OrderedLocusNames=CNBA6020;
OS Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=283643;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B-3501A;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: The SPT4-SPT5 complex mediates both activation and inhibition
CC of transcription elongation, and plays a role in pre-mRNA processing.
CC This complex seems to be important for the stability of the RNA
CC polymerase II elongation machinery on the chromatin template but not
CC for the inherent ability of this machinery to translocate down the gene
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the SPT4-SPT5 complex. Interacts with RNA
CC polymerase II (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SPT5 family. {ECO:0000305}.
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DR EMBL; AAEY01000004; EAL23077.1; -; Genomic_DNA.
DR RefSeq; XP_777724.1; XM_772631.1.
DR AlphaFoldDB; P0CR71; -.
DR SMR; P0CR71; -.
DR EnsemblFungi; AAW41151; AAW41151; CNA06210.
DR EnsemblFungi; EAL23077; EAL23077; CNBA6020.
DR GeneID; 4933866; -.
DR KEGG; cnb:CNBA6020; -.
DR VEuPathDB; FungiDB:CNBA6020; -.
DR HOGENOM; CLU_003537_1_0_1; -.
DR Proteomes; UP000001435; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0032784; P:regulation of DNA-templated transcription, elongation; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd06081; KOW_Spt5_1; 1.
DR CDD; cd06082; KOW_Spt5_2; 1.
DR CDD; cd06083; KOW_Spt5_3; 1.
DR CDD; cd06084; KOW_Spt5_4; 1.
DR CDD; cd06085; KOW_Spt5_5; 1.
DR CDD; cd09888; NGN_Euk; 1.
DR Gene3D; 2.30.30.30; -; 3.
DR Gene3D; 3.30.70.940; -; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041975; KOW_Spt5_2.
DR InterPro; IPR041976; KOW_Spt5_3.
DR InterPro; IPR041977; KOW_Spt5_4.
DR InterPro; IPR041978; KOW_Spt5_5.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_L2_dom2.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR024945; Spt5_C_dom.
DR InterPro; IPR022581; Spt5_N.
DR InterPro; IPR017071; TF_Spt5_eukaryote.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; PTHR11125; 1.
DR Pfam; PF00467; KOW; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR Pfam; PF11942; Spt5_N; 1.
DR PIRSF; PIRSF036945; Spt5; 1.
DR SMART; SM01104; CTD; 1.
DR SMART; SM00739; KOW; 4.
DR SUPFAM; SSF50104; SSF50104; 1.
PE 3: Inferred from homology;
KW mRNA processing; Nucleus; Transcription.
FT CHAIN 1..1152
FT /note="Transcription elongation factor SPT5"
FT /id="PRO_0000410297"
FT REGION 1..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 906..966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..94
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1152 AA; 123902 MW; 44BBC0F6B4460B1C CRC64;
MSDIEIKSSP PESPAEEQEE RRLAGRKRAR AVDPDEEDDD TQVVNNQDEE NNPKEDDGEE
GGNAQAEGAD EGEDDEDEDE DDDDDDEDED DEDDDGERRA KRRRKQKKFR FLDVEAEVDD
EDEEEDEDND YGDVAEFIDE APEDVGARDD HQHRRLNRVF GRNEEEDVHD IVQRLKERHA
GAARYNGDSD AVPQRLLMPG VNDPSLWKVV VKSGREHAIC ASIFRKVFAQ QYSANPIDVI
SVFCRDSIPG MIFIEARQSA SVSAAVNGIV GIFMSRGVNL VPIEEMAPLL KMKKKDVNLT
PGMWVRMKRG KHAGDLAQVV DVDQITSGVV GIKFIPRIDL TPREKRKERI AIGKPGGVRP
PARLFAYDDV RKIYGRQSVR QGAQGSYLFD NDEYVDGFCI KDVKIPAVAT EDVNPTLEEI
SRFTGDDDST AKFDLSAIAD ANKNLSTSLL FPGDKIEVYE GEQTGLYGIV EAVSPDVIAI
KAEGGEVHGQ TVEVPARSVR KRFDVGEHVK VLGGKHTDAS GMVVEVKGDI VTLMSDLGEQ
EIKVFSKDLR KAADTTNLTV TKGLYDVHDM VMLDSTTAGV VTKVEGGLLR ILDQNGAAKS
VSPEQVSIRR DNKRFAVATD SQGNDMKVGD NMKETDGEMR QGEVFNIFRS IFVFLYNREY
TDNFGVFVAR ANSLISVTPK SAVNDLTKIN PALNQQLPYG GASLMPAPTA NLNRNRLINT
LVVVTKGTSK GLIGVIKDVQ GENARVELKH NNKTLSVNLA SLKRKDQKTG ATFPLEMAGI
ASAAGGYGAR PNAGQYDINP YGGATAMHPS MGGQTPALMG GRTPAARFGQ TPNPYAAGVQ
NGKTPNPYAA GVGGKTPSAA NASGGKTPAW GASGGKTPAY GMASGGKTPA YGMQGGKTPN
AYAMAPPGPS GGRTPAYGAY GRPEASGSRP SVMAPPSAPY SAPYSAPTPA GNGAPTPAIP
GNPYTAPTPY GAPTPYAAPT PGMPSLSAPT PGPGAGIAPT PFGAPTPYGA QSYGASAQQQ
RGLPWDWALD FRNVIVEIGP SYRPGSRNPL HFKRGFFDGK RFGYNDIIGE NVRAILLDDP
SVVEEIPAEY LRPAKADSQG QVVVVIGGGP EQKGQQRTTQ YENGGSWMME LEGGDMAPLV
VDGADLCRIW KV
