ID   SPT5_SACS2              Reviewed;         152 AA.
AC   P96036;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Transcription elongation factor Spt5 {ECO:0000255|HAMAP-Rule:MF_00950};
GN   Name=spt5 {ECO:0000255|HAMAP-Rule:MF_00950}; Synonyms=nusG;
GN   OrderedLocusNames=SSO0347;
OS   Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS   (Sulfolobus solfataricus).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Saccharolobus.
OX   NCBI_TaxID=273057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9252104; DOI=10.1016/s0167-4838(97)00073-3;
RA   Geiger M., Groebner P., Piendl W.;
RT   "Nucleotide sequence of a gene cluster encoding NusG and the L11-L1-L10-L12
RT   ribosomal proteins from the thermophilic archaeon Sulfolobus
RT   solfataricus.";
RL   Biochim. Biophys. Acta 1340:170-177(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=11427726; DOI=10.1073/pnas.141222098;
RA   She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA   Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA   Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA   Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA   Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA   Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT   "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
CC   -!- FUNCTION: Stimulates transcription elongation. {ECO:0000255|HAMAP-
CC       Rule:MF_00950}.
CC   -!- SUBUNIT: Heterodimer composed of Spt4 and Spt5. Interacts with RNA
CC       polymerase (RNAP). {ECO:0000255|HAMAP-Rule:MF_00950}.
CC   -!- SIMILARITY: Belongs to the archaeal Spt5 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00950}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK40676.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; U85262; AAB99523.1; -; Genomic_DNA.
DR   EMBL; AE006641; AAK40676.1; ALT_INIT; Genomic_DNA.
DR   PIR; E90177; E90177.
DR   RefSeq; WP_009990638.1; NC_002754.1.
DR   AlphaFoldDB; P96036; -.
DR   SMR; P96036; -.
DR   STRING; 273057.SSO0347; -.
DR   EnsemblBacteria; AAK40676; AAK40676; SSO0347.
DR   GeneID; 44129317; -.
DR   KEGG; sso:SSO0347; -.
DR   PATRIC; fig|273057.12.peg.337; -.
DR   eggNOG; arCOG01920; Archaea.
DR   HOGENOM; CLU_113589_0_0_2; -.
DR   InParanoid; P96036; -.
DR   OMA; FSEIEHF; -.
DR   PhylomeDB; P96036; -.
DR   Proteomes; UP000001974; Chromosome.
DR   GO; GO:0005840; C:ribosome; IEA:InterPro.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 3.30.70.940; -; 1.
DR   HAMAP; MF_00950; Spt5_arch; 1.
DR   InterPro; IPR005824; KOW.
DR   InterPro; IPR005100; NGN-domain.
DR   InterPro; IPR006645; NGN_dom.
DR   InterPro; IPR036735; NGN_dom_sf.
DR   InterPro; IPR014722; Rib_L2_dom2.
DR   InterPro; IPR005825; Ribosomal_L24/26_CS.
DR   InterPro; IPR011590; Spt5_arc.
DR   InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR   Pfam; PF00467; KOW; 1.
DR   Pfam; PF03439; Spt5-NGN; 1.
DR   SMART; SM00739; KOW; 1.
DR   SMART; SM00738; NGN; 1.
DR   SUPFAM; SSF50104; SSF50104; 1.
DR   TIGRFAMs; TIGR00405; KOW_elon_Spt5; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..152
FT                   /note="Transcription elongation factor Spt5"
FT                   /id="PRO_0000113980"
FT   DOMAIN          99..128
FT                   /note="KOW"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00950"
SQ   SEQUENCE   152 AA;  16671 MW;  10A584E60D089915 CRC64;
     MEKPNMRNYY AIKVVGGQEI NVALMLEERI KTNNIKGIYA IIVPPNLKGY VVLEAEGLHI
     VKPLIAGIRN ARGLAQGLLP RDEILKIVSR KTVGPTVKPG DVVEVISGPF RGTQAQVIRV
     EEAKGEVVLN ILESAFPLQV TVPLDQIKVS KR