ID   SPT5_SULAC              Reviewed;         152 AA.
AC   P27341; Q4J8U9;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Transcription elongation factor Spt5 {ECO:0000255|HAMAP-Rule:MF_00950};
GN   Name=spt5 {ECO:0000255|HAMAP-Rule:MF_00950}; Synonyms=nusG;
GN   OrderedLocusNames=Saci_1460;
OS   Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC
OS   15157 / NCIMB 11770).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=330779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1658539; DOI=10.1111/j.1365-2958.1991.tb01916.x;
RA   Ramirez C., Matheson A.T.;
RT   "A gene in the archaebacterium Sulfolobus solfataricus that codes for a
RT   protein equivalent to the alpha subunits of the signal recognition particle
RT   receptor in eukaryotes.";
RL   Mol. Microbiol. 5:1687-1693(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX   PubMed=7711082; DOI=10.1016/0167-4781(95)00024-b;
RA   Moll R., Schmidtke S., Schaefer G.;
RT   "Nucleotide sequence of a gene cluster encoding ribosomal proteins in the
RT   thermoacidophilic crenarchaeon Sulfolobus acidocaldarius.";
RL   Biochim. Biophys. Acta 1261:315-318(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX   PubMed=15995215; DOI=10.1128/jb.187.14.4992-4999.2005;
RA   Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E.,
RA   Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.;
RT   "The genome of Sulfolobus acidocaldarius, a model organism of the
RT   Crenarchaeota.";
RL   J. Bacteriol. 187:4992-4999(2005).
RN   [4]
RP   SIMILARITY.
RX   PubMed=7899076; DOI=10.1093/nar/23.4.565;
RA   Ouzounis C., Kyrpides N., Sander C.;
RT   "Novel protein families in archaean genomes.";
RL   Nucleic Acids Res. 23:565-570(1995).
CC   -!- FUNCTION: Stimulates transcription elongation. {ECO:0000255|HAMAP-
CC       Rule:MF_00950}.
CC   -!- SUBUNIT: Heterodimer composed of Spt4 and Spt5. Interacts with RNA
CC       polymerase (RNAP). {ECO:0000255|HAMAP-Rule:MF_00950}.
CC   -!- SIMILARITY: Belongs to the archaeal Spt5 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00950}.
CC   -!- CAUTION: Was originally thought to originate from S.solfataricus strain
CC       P1, but the culture was contaminated with S.acidocaldarius.
CC       {ECO:0000305|PubMed:1658539}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X58538; CAA41431.1; -; Genomic_DNA.
DR   EMBL; X77509; CAA54645.1; -; Genomic_DNA.
DR   EMBL; CP000077; AAY80781.1; -; Genomic_DNA.
DR   PIR; S53705; S53705.
DR   RefSeq; WP_011278283.1; NC_007181.1.
DR   AlphaFoldDB; P27341; -.
DR   SMR; P27341; -.
DR   STRING; 330779.Saci_1460; -.
DR   EnsemblBacteria; AAY80781; AAY80781; Saci_1460.
DR   GeneID; 3473499; -.
DR   KEGG; sai:Saci_1460; -.
DR   PATRIC; fig|330779.12.peg.1404; -.
DR   eggNOG; arCOG01920; Archaea.
DR   HOGENOM; CLU_113589_0_0_2; -.
DR   OMA; FSEIEHF; -.
DR   Proteomes; UP000001018; Chromosome.
DR   GO; GO:0005840; C:ribosome; IEA:InterPro.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 3.30.70.940; -; 1.
DR   HAMAP; MF_00950; Spt5_arch; 1.
DR   InterPro; IPR005824; KOW.
DR   InterPro; IPR005100; NGN-domain.
DR   InterPro; IPR006645; NGN_dom.
DR   InterPro; IPR036735; NGN_dom_sf.
DR   InterPro; IPR014722; Rib_L2_dom2.
DR   InterPro; IPR005825; Ribosomal_L24/26_CS.
DR   InterPro; IPR011590; Spt5_arc.
DR   InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR   Pfam; PF00467; KOW; 1.
DR   Pfam; PF03439; Spt5-NGN; 1.
DR   SMART; SM00739; KOW; 1.
DR   SMART; SM00738; NGN; 1.
DR   SUPFAM; SSF50104; SSF50104; 1.
DR   TIGRFAMs; TIGR00405; KOW_elon_Spt5; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..152
FT                   /note="Transcription elongation factor Spt5"
FT                   /id="PRO_0000113979"
FT   DOMAIN          99..129
FT                   /note="KOW"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00950"
SQ   SEQUENCE   152 AA;  16877 MW;  316F31BBCC22620D CRC64;
     MEDFKYRNYY VLRVTGGQEI NVALILEERI KTNNINEIFS VVVPPNIKGY VILEATGPHV
     VKLISSGIRH VKGVAHGLIQ KEDVTKFVSK SVALPAVKEG DLVEVISGPF RGMQAQVVRV
     ESTKNEVVLN ILESSYPVQV TVPLEQVKPV KR