SPT5_YARLI
ID SPT5_YARLI Reviewed; 980 AA.
AC Q6CC84;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Transcription elongation factor SPT5;
DE AltName: Full=Chromatin elongation factor SPT5;
GN Name=SPT5; OrderedLocusNames=YALI0C11561g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: The SPT4-SPT5 complex mediates both activation and inhibition
CC of transcription elongation, and plays a role in pre-mRNA processing.
CC This complex seems to be important for the stability of the RNA
CC polymerase II elongation machinery on the chromatin template but not
CC for the inherent ability of this machinery to translocate down the gene
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the SPT4-SPT5 complex. Interacts with RNA
CC polymerase II (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SPT5 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR382129; CAG82038.1; -; Genomic_DNA.
DR RefSeq; XP_501728.1; XM_501728.1.
DR AlphaFoldDB; Q6CC84; -.
DR SMR; Q6CC84; -.
DR STRING; 4952.CAG82038; -.
DR PRIDE; Q6CC84; -.
DR EnsemblFungi; CAG82038; CAG82038; YALI0_C11561g.
DR GeneID; 2909431; -.
DR KEGG; yli:YALI0C11561g; -.
DR VEuPathDB; FungiDB:YALI0_C11561g; -.
DR HOGENOM; CLU_003537_1_0_1; -.
DR InParanoid; Q6CC84; -.
DR OMA; VGYMNTP; -.
DR Proteomes; UP000001300; Chromosome C.
DR GO; GO:0032044; C:DSIF complex; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0060195; P:negative regulation of antisense RNA transcription; IEA:EnsemblFungi.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0034243; P:regulation of transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR CDD; cd06081; KOW_Spt5_1; 1.
DR CDD; cd06082; KOW_Spt5_2; 1.
DR CDD; cd06083; KOW_Spt5_3; 1.
DR CDD; cd06084; KOW_Spt5_4; 1.
DR CDD; cd06085; KOW_Spt5_5; 1.
DR CDD; cd09888; NGN_Euk; 1.
DR Gene3D; 2.30.30.30; -; 3.
DR Gene3D; 3.30.70.940; -; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041975; KOW_Spt5_2.
DR InterPro; IPR041976; KOW_Spt5_3.
DR InterPro; IPR041977; KOW_Spt5_4.
DR InterPro; IPR041978; KOW_Spt5_5.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_L2_dom2.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR024945; Spt5_C_dom.
DR InterPro; IPR022581; Spt5_N.
DR InterPro; IPR017071; TF_Spt5_eukaryote.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; PTHR11125; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR Pfam; PF11942; Spt5_N; 1.
DR PIRSF; PIRSF036945; Spt5; 1.
DR SMART; SM01104; CTD; 1.
DR SMART; SM00739; KOW; 4.
DR SUPFAM; SSF50104; SSF50104; 1.
PE 3: Inferred from homology;
KW mRNA processing; Nucleus; Reference proteome; Transcription.
FT CHAIN 1..980
FT /note="Transcription elongation factor SPT5"
FT /id="PRO_0000238567"
FT REGION 1..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 751..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..63
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..116
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..822
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 874..900
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 980 AA; 106379 MW; 209AC019AD7698F0 CRC64;
MSDREESGSP EPRSKIEEDL ESDEEVKTIK SEEVDKTQDN VEDEDDEEEE EEEEEEEEED
DDEEDVRQRK KPRRERRNQF LDVEAEVDED EEDLEEDEDG LIGEDGFVAE PDADEPDASD
DRFHREMDRR REAIAEEDAE RLADEYREKY GRSTANKYRG DSGVIPQHLL LPSVNEPSIW
GIRCKPGKEK ELVRQCLRKK LSLQKSRNPL EIMSVFQRDT FTGYIYMEAR NQQAVTVALK
GLVNVYPQNM ILVPIKEYVD LLRATKSAET ELVPGAYVRL KRGKYGGDLA IVENLSENGL
EVRLKLVPRL DYGRNAEAGI DGKRKRVARI PPPRLFSEQE ASQYDPRNLQ KRGPNAYVYA
GDEYIGGFLY KDFKITLVNA ENVAPKLEEL TRFNSEETDG IDLASLAQSL RKSAAAVQFQ
GGDVVEVSEG EQTGVQGTVI STHGDIVTVE ATTAPLVGKR IDLPSRSLRK KFAIGDHVRV
ISGNFLDDTG LIVGLEDDSV TLLSDLNKKE VTVFAKDLKK VSDIGGSHQV GDYELHDFVQ
LDALHVGCIV KVERDSLKVL DQEGTVRSVT PSSITMKLTR NMEGLATDSN GSEIKIGDTV
RETVGEGRQG AVLHIYKNTL FLSSRSLGVF VAKAFKVNTI VAKGARTQSN SQATGPDLTK
MNPAVYNARP GQMAPPVMPK QGGFDRLKGK HVAIGPGSQH KGCKGIVKET TDDIARVELH
APCKVVNVLK HQLRIYDDYK KTYLSYMEFA TPRGMRSGGG RPGGPPGPGG PGSGGQTPSW
GGGGKTPSWG AGGKTPSWGS KTPSWGGAKT SSWGSRTPAA NAGGAQTPAW GAMGNKTPSW
GASESRTPAW GGAKTPAWGA AGAGSKTPAF GVARTPSWKS SSAGTYGGSS SRNKGWEDLG
SGNSAPTPGY AAATPGEMMG APTPGAAHHP WEDSAPTPAA YNDARTPGVY DPRGSGPAQA
ETPAAWSTDD APRYDDSPTP
