SPT61_ARATH
ID SPT61_ARATH Reviewed; 1647 AA.
AC A8MS85; O80815; Q0WN83;
DT 05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Transcription elongation factor SPT6 homolog {ECO:0000305};
DE Short=AtSPT6 {ECO:0000303|PubMed:20139304};
GN Name=SPT6 {ECO:0000303|PubMed:20139304};
GN Synonyms=GTB1 {ECO:0000312|EMBL:AEE34373.1},
GN SPT6L {ECO:0000303|PubMed:21948524};
GN OrderedLocusNames=At1g65440 {ECO:0000312|Araport:AT1G65440};
GN ORFNames=T8F5.22 {ECO:0000312|EMBL:AAC27151.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-327.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP INTERACTION WITH IWS1.
RX PubMed=20139304; DOI=10.1073/pnas.0909198107;
RA Li L., Ye H., Guo H., Yin Y.;
RT "Arabidopsis IWS1 interacts with transcription factor BES1 and is involved
RT in plant steroid hormone brassinosteroid regulated gene expression.";
RL Proc. Natl. Acad. Sci. U.S.A. 107:3918-3923(2010).
RN [5]
RP FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=21948524; DOI=10.1093/mp/ssr073;
RA Gu X.L., Wang H., Huang H., Cui X.F.;
RT "SPT6L encoding a putative WG/GW-repeat protein regulates apical-basal
RT polarity of embryo in Arabidopsis.";
RL Mol. Plant 5:249-259(2012).
CC -!- FUNCTION: Transcription elongation factor that enhances the
CC transcription elongation by RNA polymerase II (RNAPII) (By similarity).
CC Plays an important role in regulating embryo apical and basal
CC patterning during early embryogenesis, partly through negative
CC regulation of the transcription factors PHABULOSA and PHAVOLUTA.
CC {ECO:0000250|UniProtKB:Q7KZ85}.
CC -!- SUBUNIT: Interacts (via N-terminus) with IWS1.
CC {ECO:0000269|PubMed:20139304}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Name=1;
CC IsoId=A8MS85-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed in shoot apical meristem, leaf primordia,
CC vasculature of young leaves, inflorescence meristem, floral meristem,
CC young floral organs, developing ovules and anthers.
CC {ECO:0000269|PubMed:21948524}.
CC -!- DEVELOPMENTAL STAGE: During embryo development, expressed throughout
CC embryos at the globular, heart, torpedo and bent-cotyledon stages.
CC {ECO:0000269|PubMed:21948524}.
CC -!- DISRUPTION PHENOTYPE: Embryonic lethality leading to aborted seed
CC development. {ECO:0000269|PubMed:21948524}.
CC -!- MISCELLANEOUS: [Isoform 1]: A number of isoforms are produced.
CC According to EST sequences. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SPT6 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC27151.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC004512; AAC27151.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE34373.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM59396.1; -; Genomic_DNA.
DR EMBL; AK229565; BAF01417.1; -; mRNA.
DR PIR; T02367; T02367.
DR RefSeq; NP_001321759.1; NM_001334206.1. [A8MS85-1]
DR RefSeq; NP_176723.3; NM_105218.5. [A8MS85-1]
DR AlphaFoldDB; A8MS85; -.
DR SMR; A8MS85; -.
DR STRING; 3702.AT1G65440.1; -.
DR iPTMnet; A8MS85; -.
DR MetOSite; A8MS85; -.
DR PaxDb; A8MS85; -.
DR PRIDE; A8MS85; -.
DR ProteomicsDB; 228315; -. [A8MS85-1]
DR EnsemblPlants; AT1G65440.1; AT1G65440.1; AT1G65440. [A8MS85-1]
DR EnsemblPlants; AT1G65440.4; AT1G65440.4; AT1G65440. [A8MS85-1]
DR GeneID; 842855; -.
DR Gramene; AT1G65440.1; AT1G65440.1; AT1G65440. [A8MS85-1]
DR Gramene; AT1G65440.4; AT1G65440.4; AT1G65440. [A8MS85-1]
DR KEGG; ath:AT1G65440; -.
DR Araport; AT1G65440; -.
DR TAIR; locus:2206330; AT1G65440.
DR eggNOG; KOG1856; Eukaryota.
DR InParanoid; A8MS85; -.
DR OrthoDB; 56990at2759; -.
DR PhylomeDB; A8MS85; -.
DR PRO; PR:A8MS85; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; A8MS85; baseline and differential.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0008023; C:transcription elongation factor complex; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0009793; P:embryo development ending in seed dormancy; IMP:UniProtKB.
DR GO; GO:0042789; P:mRNA transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0034728; P:nucleosome organization; IBA:GO_Central.
DR GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR CDD; cd09928; SH2_Cterm_SPT6_like; 1.
DR CDD; cd09918; SH2_Nterm_SPT6_like; 1.
DR Gene3D; 1.10.10.2740; -; 1.
DR Gene3D; 1.10.10.650; -; 1.
DR Gene3D; 1.10.3500.10; -; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 3.30.420.140; -; 1.
DR Gene3D; 3.30.505.10; -; 2.
DR InterPro; IPR041692; HHH_9.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR022967; S1_dom.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR028083; Spt6_acidic_N_dom.
DR InterPro; IPR042066; Spt6_death-like.
DR InterPro; IPR032706; Spt6_HHH.
DR InterPro; IPR035420; Spt6_SH2.
DR InterPro; IPR035018; Spt6_SH2_C.
DR InterPro; IPR035019; Spt6_SH2_N.
DR InterPro; IPR028231; Spt6_YqgF.
DR InterPro; IPR023323; Tex-like_dom_sf.
DR InterPro; IPR023319; Tex-like_HTH_dom_sf.
DR InterPro; IPR017072; TF_Spt6.
DR InterPro; IPR006641; YqgF/RNaseH-like_dom.
DR InterPro; IPR037027; YqgF/RNaseH-like_dom_sf.
DR PANTHER; PTHR10145; PTHR10145; 1.
DR Pfam; PF14635; HHH_7; 1.
DR Pfam; PF17674; HHH_9; 1.
DR Pfam; PF14633; SH2_2; 1.
DR Pfam; PF14632; SPT6_acidic; 1.
DR Pfam; PF14639; YqgF; 1.
DR PIRSF; PIRSF036947; Spt6; 1.
DR SMART; SM00316; S1; 1.
DR SMART; SM00732; YqgFc; 1.
DR SUPFAM; SSF47781; SSF47781; 2.
DR SUPFAM; SSF50249; SSF50249; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
DR SUPFAM; SSF55550; SSF55550; 2.
DR PROSITE; PS50126; S1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Elongation factor; Nucleus; Protein biosynthesis;
KW Reference proteome; Repeat; Transcription; Transcription regulation.
FT CHAIN 1..1647
FT /note="Transcription elongation factor SPT6 homolog"
FT /id="PRO_0000437500"
FT DOMAIN 1103..1174
FT /note="S1 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT REPEAT 1443..1444
FT /note="1"
FT /evidence="ECO:0000305|PubMed:21948524"
FT REPEAT 1452..1453
FT /note="2"
FT /evidence="ECO:0000305|PubMed:21948524"
FT REPEAT 1511..1512
FT /note="3"
FT /evidence="ECO:0000305|PubMed:21948524"
FT REPEAT 1522..1523
FT /note="4"
FT /evidence="ECO:0000305|PubMed:21948524"
FT REPEAT 1530..1531
FT /note="5"
FT /evidence="ECO:0000305|PubMed:21948524"
FT REPEAT 1547..1548
FT /note="6"
FT /evidence="ECO:0000305|PubMed:21948524"
FT REPEAT 1563..1564
FT /note="7"
FT /evidence="ECO:0000305|PubMed:21948524"
FT REPEAT 1574..1575
FT /note="8"
FT /evidence="ECO:0000305|PubMed:21948524"
FT REPEAT 1601..1602
FT /note="9"
FT /evidence="ECO:0000305|PubMed:21948524"
FT REPEAT 1615..1616
FT /note="10"
FT /evidence="ECO:0000305|PubMed:21948524"
FT REPEAT 1630..1631
FT /note="11"
FT /evidence="ECO:0000305|PubMed:21948524"
FT REPEAT 1646..1647
FT /note="12"
FT /evidence="ECO:0000305|PubMed:21948524"
FT REGION 1..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1429..1647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1443..1647
FT /note="12 X 2 AA repeats of [WG]-[GW] repeats"
FT /evidence="ECO:0000305"
FT COMPBIAS 30..69
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..153
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..187
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1439..1456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1491..1505
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1506..1521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1545..1562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1647 AA; 185034 MW; 0280D05F681709CE CRC64;
MARNAISDDE EDHELEDDDG EPVHGDPAEH DENDDEEDDD DVGNEYENDG FIVNDEDEEE
EEEEDEERKD SDEERQKKKK KRKKKDEGLD EDDYLLLQDN NVKFKKRQYK RLKKAQREQG
NGQGESSDDE FDSRGGTRRS AEDKIKDRLF DDVDVDDPPD DVGDEEDLVV EEDVVGSEDE
MADFIVDEDD EHGPPKRGNS KKKKYRQGSD ITAMRDANEI FGDVDELLTI RKKGLASNQR
MERRLEDEFE PTVLSEKYMT GNDDEIRQLD IPERMQISEE STGSPPVDEI SIEEESNWIY
AQLASQLRES DGTFDGRGFS VNKDDIAKFL ELHHVQKLEI PFIAMYRKEQ CRSLLDTGDF
DGANQGKKPE TKWHKVFWMI HDLDKKWLLL RKRKMALHGY YTKRYEEESR RVYDETRLNL
NQYLFESVIK SLKVAETERE VDDVDSKFNL HFPPGEIGVD EGQYKRPKRK SQYSICSKAG
LWEVANKFGY SAEQLGLALS LEKLVDELED AKETPEEMAK NFVCAMFENS LAVLKGARHM
AAVEISCEPS VKKYVRGIYM ENAVVSTSPT ADGNTVIDSF HQFSGIKWLR EKPLSKFEGA
QWLLIQKGEE EKLLQVTFKL PENYMNRLIS DCNEHYLSVG VSKYAQLWNE QRKLILEDAL
HAFLLPSMEK EARSLLTSRA KSRLLSEYGQ ALWNKVSAGP YQKKEMDINL DEEAAPRVMA
CCWGPGKPPN TFVMLDSSGE VLDVLYAGSL TSRSQNVNDQ QRKKSDQDRV LKFMMDHQPH
VVALGAVNLS CTRLKDDIYE VIFQMVEEKP RDVGHGMDDL SIVYVDESLP RLYENSRISG
EQLPQQSGNV RRAVALGRYL QNPLAMVATL CGPGREILSW KLHPLENFLQ LDEKYGMVEQ
VMVDITNQVG IDINLAASHD WFFSPLQFIS GLGPRKAASL QRSLVRAGSI FVRKDLIMHG
LGKKVFVNAA GFLRIRRSGL AASSSQFIDL LDDTRIHPES YSLAQELAKD IYDEDVRGDS
NDDEDAIEMA IEHVRDRPAS LRKVVLDEYL ASKKRENKKE TYSNIIRELS CGFQDWRIPF
KEPSPDEEFY MISGETEDTI AEGRIVQASV RRLQNGRAIC VLDSGLTGML MKEDFSDDGR
DIVDLADQLK EGDILTCKIK SIQKQRYQVF LICKESEMRN NRHQHNQNVD AYYHEDRNSL
QLVKEKARKE KELVRKHFKS RMIVHPRFQN ITADQATEYL SDKDFGESIV RPSSRGLNFL
TLTLKIYDGV YAHKEIAEGG KENKDITSLQ CIGKTLTIGE DTFEDLDEVM DRYVDPLVSH
LKTMLNYRKF RKGTKSEVDD LLRIEKGENP SRIVYCFGIS HEHPGTFILS YIRSTNPHHE
YIGLYPKGFK FRKRMFEDID RLVAYFQRHI DDPLQESAPS IRSIAAKVPM RSPADHGSSG
GSGWGSSQSE GGWKGNSDRS GSGRGGEYRN GGGRDGHPSG APRPYGGRGR GRGRGRRDDM
NSDRQDGNGD WGNNDTGTAD GGWGNSGGGG WGSESAGKKT GGGSTGGWGS ESGGNKSDGA
GSWGSGSGGG GSGGWGNDSG GKKSSEDGGF GSGSGGGGSD WGNESGGKKS SADGGWGSES
GGKKSDGEGG WGNEPSSRKS DGGGGGW