SPT6_ASPFU
ID SPT6_ASPFU Reviewed; 1420 AA.
AC Q4WWH6;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Transcription elongation factor spt6;
DE AltName: Full=Chromatin elongation factor spt6;
GN Name=spt6; ORFNames=AFUA_3G05890;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Plays a role in maintenance of chromatin structure during RNA
CC polymerase II transcription elongation thereby repressing transcription
CC initiation from cryptic promoters. Mediates the reassembly of
CC nucleosomes onto the promoters of at least a selected set of genes
CC during repression; the nucleosome reassembly is essential for
CC transcriptional repression (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SPT6 family. {ECO:0000305}.
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DR EMBL; AAHF01000002; EAL92977.1; -; Genomic_DNA.
DR RefSeq; XP_755015.1; XM_749922.1.
DR AlphaFoldDB; Q4WWH6; -.
DR SMR; Q4WWH6; -.
DR STRING; 746128.CADAFUBP00004232; -.
DR PRIDE; Q4WWH6; -.
DR EnsemblFungi; EAL92977; EAL92977; AFUA_3G05890.
DR GeneID; 3512651; -.
DR KEGG; afm:AFUA_3G05890; -.
DR VEuPathDB; FungiDB:Afu3g05890; -.
DR eggNOG; KOG1856; Eukaryota.
DR HOGENOM; CLU_001680_0_1_1; -.
DR InParanoid; Q4WWH6; -.
DR OMA; LCNGFKT; -.
DR OrthoDB; 56990at2759; -.
DR Proteomes; UP000002530; Chromosome 3.
DR GO; GO:0000791; C:euchromatin; IEA:EnsemblFungi.
DR GO; GO:0005721; C:pericentric heterochromatin; IEA:EnsemblFungi.
DR GO; GO:0008023; C:transcription elongation factor complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR GO; GO:0001073; F:transcription antitermination factor activity, DNA binding; IEA:EnsemblFungi.
DR GO; GO:0000433; P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose; IEA:EnsemblFungi.
DR GO; GO:0140673; P:co-transcriptional chromatin reassembly; IEA:EnsemblFungi.
DR GO; GO:0042789; P:mRNA transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR GO; GO:0006334; P:nucleosome assembly; IEA:EnsemblFungi.
DR GO; GO:0034728; P:nucleosome organization; IBA:GO_Central.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:EnsemblFungi.
DR GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR GO; GO:0071931; P:positive regulation of transcription involved in G1/S transition of mitotic cell cycle; IEA:EnsemblFungi.
DR GO; GO:0000414; P:regulation of histone H3-K36 methylation; IEA:EnsemblFungi.
DR GO; GO:0031440; P:regulation of mRNA 3'-end processing; IEA:EnsemblFungi.
DR GO; GO:0043618; P:regulation of transcription from RNA polymerase II promoter in response to stress; IEA:EnsemblFungi.
DR GO; GO:0001178; P:regulation of transcriptional start site selection at RNA polymerase II promoter; IEA:EnsemblFungi.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR CDD; cd09928; SH2_Cterm_SPT6_like; 1.
DR CDD; cd09918; SH2_Nterm_SPT6_like; 1.
DR Gene3D; 1.10.10.2740; -; 1.
DR Gene3D; 1.10.10.650; -; 1.
DR Gene3D; 1.10.3500.10; -; 1.
DR Gene3D; 3.30.420.140; -; 1.
DR Gene3D; 3.30.505.10; -; 2.
DR InterPro; IPR041692; HHH_9.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR028083; Spt6_acidic_N_dom.
DR InterPro; IPR042066; Spt6_death-like.
DR InterPro; IPR032706; Spt6_HHH.
DR InterPro; IPR028088; Spt6_HTH_DNA-bd_dom.
DR InterPro; IPR035420; Spt6_SH2.
DR InterPro; IPR035018; Spt6_SH2_C.
DR InterPro; IPR035019; Spt6_SH2_N.
DR InterPro; IPR028231; Spt6_YqgF.
DR InterPro; IPR023323; Tex-like_dom_sf.
DR InterPro; IPR023319; Tex-like_HTH_dom_sf.
DR InterPro; IPR017072; TF_Spt6.
DR InterPro; IPR037027; YqgF/RNaseH-like_dom_sf.
DR PANTHER; PTHR10145; PTHR10145; 1.
DR Pfam; PF14635; HHH_7; 1.
DR Pfam; PF17674; HHH_9; 1.
DR Pfam; PF14641; HTH_44; 1.
DR Pfam; PF14633; SH2_2; 1.
DR Pfam; PF14632; SPT6_acidic; 1.
DR Pfam; PF14639; YqgF; 1.
DR PIRSF; PIRSF036947; Spt6; 1.
DR SUPFAM; SSF47781; SSF47781; 2.
DR SUPFAM; SSF50249; SSF50249; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; SH2 domain; Transcription;
KW Transcription regulation.
FT CHAIN 1..1420
FT /note="Transcription elongation factor spt6"
FT /id="PRO_0000238569"
FT DOMAIN 1230..1330
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT REGION 1..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1186..1208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..30
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..95
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1187..1208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1420 AA; 163634 MW; 52E823BDD8C3E24A CRC64;
MSARDFVEGE AVLDDEENEN EEEQEEDYDG EVHEGAGTMN HYNDSSEEEE EDDDDEEAAR
AIREGFIVDE DEEIEERAER RREKRKRRRE EREREDEHLD EEDLELIGEL NPAFQSAAAT
ESKFKRLKRG HKDHRQASQG IDDIFNSDED EEAAGDYGRP SHRRPMHDEM KDFIEEDVFT
DDELERERED LEIARPAKRG VTGLGATDAA GLDENALEDM RAAFGDGNEY LFALEMEEQE
EEQEEDQEKH LDLKDVFEPS QLAERMLTEE DNQIRLLDEP ERHQLARKPY RNLVLTEEQF
REEAAWIANL MLLKKRIEPE LREPFQRSVA KVLEFLVTDD WEVPFIFQHR KDYMIHATKV
PVAGAPADGD TSQYTIKAEK LLNMTDLWDI FDHDLKFRAL VEKRNTIQKT YDNLQSLFNV
NDSVVQDMLS TAVTMEELQD VQDYVHFQYA SQLRDINLMN GEANGDTHRR KATGRSFFER
VRNGKAYGLV RAFGITADAF AQNALKEGRR QYTEDPAERP EEMADSFIDN DFSNASHVLK
AAKALFAEEI VMSPKMRKVI RQAYYMNGAV DCFRTEKGLR RIDEQHPYYE FKYLRNQQLS
DIARQPELYL RMLKAEEEGL VEVKVRFENF DHFRQRLYPD IESDNYSEIA DAWNRTRREV
LDMALGKLER LINRSVKENI RQECENHVAK ECREAFSQRL DQAPYKPKGM VLGTVPRVLA
MSTGTGIVGR DPIHWAYVEE DGRVLENGKF VDLSIGDRDR SIPDGKDVEA LIELLERRRP
DVIGVSGMSP ETRKLYKLLT ELVEKKDLRG ATYTDERDEE ISDPLEVVIV NDEVARLYQH
SERAKKDHPS FGPLTHYCVA LAKYLQSPLK EYASLGRDIV SIQFKRGQQL VAQELLLKQL
ETALVDMVNL VGVDINEAVT DPATANLLPY VCGLGPRKAA HLLKIVNMNG GVVNNRVELL
GVNAQYPAMG VKVWNNCASF LFIDFENADP DADPLDNTRV HPEDYDIARK MAADALELDE
EDIKAETDEN GPGAIVRKLF RDEAQDRVND LILEEYAEQL EKNLNQRKRA TLETIRAELQ
QPYEELRKQF ALLSTDDVFT MLTGETSDTL AEGMVVPISI KRITDDHIDG KLDCGVDVLV
PESELTDRYD IPVRALYSLH QTLPAKVLFL NKKNFLCNVS LREEQVSRPT PRPRDHMRGE
WDDRQEAKDR EMLQEKTQSG GRVMRVIKHP LFRPFNSTQA EEFLGSQSRG DVVIRPSSKG
PDHLAVTWKV ADGIFQHIDV LELDKENEFS VGRTLKVGGR YTYSDLDDLI FNHVKAMAKK
VDEMMLHEKY QEGSKDATYS WLNTYTKANP RRSAYAFCID PKHPGYFQLC FKAGENAQLH
SWPVKVIPQG YELQRNPYPD MRALCNGFKL LFTNMQAGKR
