ID   SPT6_CANAL              Reviewed;        1401 AA.
AC   Q3MNT0; A0A1D8PRK1; Q5A0G3;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Transcription elongation factor SPT6;
DE   AltName: Full=Chromatin elongation factor SPT6;
GN   Name=SPT6; OrderedLocusNames=CAALFM_C704300WA;
GN   ORFNames=CaJ7.0509, CaO19.7136;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15937140; DOI=10.1534/genetics.104.034652;
RA   Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T.,
RA   Mikami Y.;
RT   "Sequence finishing and gene mapping for Candida albicans chromosome 7 and
RT   syntenic analysis against the Saccharomyces cerevisiae genome.";
RL   Genetics 170:1525-1537(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Plays a role in maintenance of chromatin structure during RNA
CC       polymerase II transcription elongation thereby repressing transcription
CC       initiation from cryptic promoters. Mediates the reassembly of
CC       nucleosomes onto the promoters of at least a selected set of genes
CC       during repression; the nucleosome reassembly is essential for
CC       transcriptional repression (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPT6 family. {ECO:0000305}.
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DR   EMBL; AP006852; BAE44930.1; -; Genomic_DNA.
DR   EMBL; CP017629; AOW30767.1; -; Genomic_DNA.
DR   RefSeq; XP_715187.1; XM_710094.1.
DR   AlphaFoldDB; Q3MNT0; -.
DR   SMR; Q3MNT0; -.
DR   BioGRID; 1226265; 1.
DR   STRING; 237561.Q3MNT0; -.
DR   PRIDE; Q3MNT0; -.
DR   GeneID; 3643171; -.
DR   KEGG; cal:CAALFM_C704300WA; -.
DR   CGD; CAL0000194756; SPT6.
DR   VEuPathDB; FungiDB:C7_04300W_A; -.
DR   eggNOG; KOG1856; Eukaryota.
DR   HOGENOM; CLU_001680_0_1_1; -.
DR   InParanoid; Q3MNT0; -.
DR   OMA; LCNGFKT; -.
DR   OrthoDB; 56990at2759; -.
DR   Proteomes; UP000000559; Chromosome 7.
DR   GO; GO:0005721; C:pericentric heterochromatin; IEA:EnsemblFungi.
DR   GO; GO:0008023; C:transcription elongation factor complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR   GO; GO:0009267; P:cellular response to starvation; IMP:CGD.
DR   GO; GO:0140673; P:co-transcriptional chromatin reassembly; IEA:EnsemblFungi.
DR   GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR   GO; GO:0036180; P:filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
DR   GO; GO:0036170; P:filamentous growth of a population of unicellular organisms in response to starvation; IMP:CGD.
DR   GO; GO:0042789; P:mRNA transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0034728; P:nucleosome organization; IBA:GO_Central.
DR   GO; GO:1900445; P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
DR   GO; GO:1900436; P:positive regulation of filamentous growth of a population of unicellular organisms in response to starvation; IMP:CGD.
DR   GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IGI:CGD.
DR   CDD; cd09928; SH2_Cterm_SPT6_like; 1.
DR   CDD; cd09918; SH2_Nterm_SPT6_like; 1.
DR   Gene3D; 1.10.10.2740; -; 1.
DR   Gene3D; 1.10.10.650; -; 1.
DR   Gene3D; 1.10.3500.10; -; 1.
DR   Gene3D; 3.30.420.140; -; 1.
DR   Gene3D; 3.30.505.10; -; 2.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR028083; Spt6_acidic_N_dom.
DR   InterPro; IPR042066; Spt6_death-like.
DR   InterPro; IPR032706; Spt6_HHH.
DR   InterPro; IPR028088; Spt6_HTH_DNA-bd_dom.
DR   InterPro; IPR035420; Spt6_SH2.
DR   InterPro; IPR035018; Spt6_SH2_C.
DR   InterPro; IPR035019; Spt6_SH2_N.
DR   InterPro; IPR028231; Spt6_YqgF.
DR   InterPro; IPR023323; Tex-like_dom_sf.
DR   InterPro; IPR023319; Tex-like_HTH_dom_sf.
DR   InterPro; IPR017072; TF_Spt6.
DR   InterPro; IPR037027; YqgF/RNaseH-like_dom_sf.
DR   PANTHER; PTHR10145; PTHR10145; 1.
DR   Pfam; PF14635; HHH_7; 1.
DR   Pfam; PF14641; HTH_44; 1.
DR   Pfam; PF14633; SH2_2; 1.
DR   Pfam; PF14632; SPT6_acidic; 1.
DR   Pfam; PF14639; YqgF; 1.
DR   PIRSF; PIRSF036947; Spt6; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; SH2 domain; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1401
FT                   /note="Transcription elongation factor SPT6"
FT                   /id="PRO_0000238571"
FT   DOMAIN          1209..1303
FT                   /note="SH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT   REGION          1..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..57
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..78
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1401 AA;  162067 MW;  B88983308D660B6C CRC64;
     MMKKKISAKK KNQQQQQLHQ PTMSEVTEEE RTRYEEEEDV RDSPSDSSEE SEDDEEEIQK
     VREGFIVDDE EDEVQTKKRK SHKRKRDKER PHYDDALDDD DLELLLENSG LKRGSSSSGK
     FKRLKRKQIE DDEDEIESQD HQGEQQLRDI FSDDEEVEEE AAPRIMDEFD GFIEEDDFSD
     EDEQTRLERR EQRKKKKQGP RIDTSNLSNV DRQSLSELFE VFGDGNEYDW ALEAQELEDA
     GAIDKEEPAS LDEVFEHSEL KERMLTEEDN LIRIIDVPER YQMYRSALTY IDLDDEELEL
     EKTWVANTLL KEKKAFLRDD WVEPFKQCVG QVVQFVSKEN LEVPFIWNHR RDYLEYVDPD
     APIPGSVREL MISEDDVWRI VKLDIEYHSL YEKRLNTEKI IDSLEIDDEL VKDIKTLDSM
     VAIQDMHDYI QFTYSKEIRQ REETQNRKHS KFALYERIRE NVLYDAVKAY GITAKEFGEN
     VQDQSSKGFE VPYRIHATDD PWESPDDMIE RLIQDDEVIF RDEKTARDAV RRTFADEIFY
     NPKIRHEVRS TYKLYASISV AVTEKGRASI DAHSPFADIK YAINRSPADL IAKPDVLLRM
     LEAERLGLVV IKVETKDFAN WFDCLFNCLK SDGFSDISEK WNQERQAVLR TAISRLCAVV
     ALNTKEDLRR ECERLIASKV RHGLLAKIEQ APFTPYGFDI GSKANVLALT FGKGDYDSAV
     VGVYIKHDGK VSRFFKSTEN PSRNRETEDA FKGQLKQFFD EDETPDVVVV SGYNANTKRL
     HDVVYNFVSE YGISVKSEFD DGSSQLVKVI WGQDETARLY QNSERAKKEF PDKPTLVKYA
     ISLGRYLQDP LLEYITLGDD ILSLTFHEHQ KLISNDLVKE VVESAFVDLV NAVGVDINES
     VRDSRLAQTL KYVGGLGPRK ASGMLRNIAQ KLGSVLTTRS QLIEYELTTR TIFINCSAAL
     KISLNKSINV KDFEIEILDT TRIHPEDYQL AMKMAADALD MDEESELHEK GGVIKELLEN
     DPSKLNLLNL NDFANQIYKL THKLKFRSLQ AIRLELIQGF AEIRSPFRIL TNEDAFFILT
     GEKPQMLKNT VIPATITKVT KNHHDPYARI RGLKVVTPSL IQGTIDENAI PRDAEYVQGQ
     VVQAVVLELY TDTFAAVLSL RREDISRAMK GGVVREYGKW DYKAEDEDIK REKAKENAKL
     AKTRNIQHPF YRNFNYKQAE EYLAPQNVGD YVIRPSSKGA SYLTITWKVG NNLFQHLLVE
     ERSRGRFKEY IVDGKTYEDL DQLAFQHIQV IAKNVTDMVR HPKFREGTLS VVHEWLESYT
     RANPKSSAYV FCYDHKSPGN FLLLFKVNVS AKVVTWHVKT EVGGYELRSS VYPNMLSLCN
     GFKQAVKMSS QQTKSYNTGY Y