ID   SPT6_CRYNB              Reviewed;        1506 AA.
AC   P0CR73; Q55Y77; Q5KLR1;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Transcription elongation factor SPT6;
DE   AltName: Full=Chromatin elongation factor SPT6;
GN   Name=SPT6; OrderedLocusNames=CNBB1380;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Plays a role in maintenance of chromatin structure during RNA
CC       polymerase II transcription elongation thereby repressing transcription
CC       initiation from cryptic promoters. Mediates the reassembly of
CC       nucleosomes onto the promoters of at least a selected set of genes
CC       during repression; the nucleosome reassembly is essential for
CC       transcriptional repression (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPT6 family. {ECO:0000305}.
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DR   EMBL; AAEY01000007; EAL22689.1; -; Genomic_DNA.
DR   RefSeq; XP_777336.1; XM_772243.1.
DR   AlphaFoldDB; P0CR73; -.
DR   SMR; P0CR73; -.
DR   EnsemblFungi; EAL22689; EAL22689; CNBB1380.
DR   GeneID; 4934230; -.
DR   KEGG; cnb:CNBB1380; -.
DR   VEuPathDB; FungiDB:CNBB1380; -.
DR   HOGENOM; CLU_001680_0_1_1; -.
DR   Proteomes; UP000001435; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR   GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:InterPro.
DR   CDD; cd09928; SH2_Cterm_SPT6_like; 1.
DR   CDD; cd09918; SH2_Nterm_SPT6_like; 1.
DR   Gene3D; 1.10.10.2740; -; 1.
DR   Gene3D; 1.10.10.650; -; 1.
DR   Gene3D; 1.10.3500.10; -; 1.
DR   Gene3D; 3.30.420.140; -; 1.
DR   Gene3D; 3.30.505.10; -; 2.
DR   InterPro; IPR041692; HHH_9.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR003029; S1_domain.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR028083; Spt6_acidic_N_dom.
DR   InterPro; IPR042066; Spt6_death-like.
DR   InterPro; IPR032706; Spt6_HHH.
DR   InterPro; IPR028088; Spt6_HTH_DNA-bd_dom.
DR   InterPro; IPR035420; Spt6_SH2.
DR   InterPro; IPR035018; Spt6_SH2_C.
DR   InterPro; IPR035019; Spt6_SH2_N.
DR   InterPro; IPR028231; Spt6_YqgF.
DR   InterPro; IPR023323; Tex-like_dom_sf.
DR   InterPro; IPR023319; Tex-like_HTH_dom_sf.
DR   InterPro; IPR017072; TF_Spt6.
DR   InterPro; IPR037027; YqgF/RNaseH-like_dom_sf.
DR   PANTHER; PTHR10145; PTHR10145; 1.
DR   Pfam; PF14635; HHH_7; 1.
DR   Pfam; PF17674; HHH_9; 1.
DR   Pfam; PF14641; HTH_44; 1.
DR   Pfam; PF14633; SH2_2; 1.
DR   Pfam; PF14632; SPT6_acidic; 1.
DR   Pfam; PF14639; YqgF; 2.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF47781; SSF47781; 2.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50126; S1; 1.
PE   3: Inferred from homology;
KW   Nucleus; SH2 domain; Transcription; Transcription regulation.
FT   CHAIN           1..1506
FT                   /note="Transcription elongation factor SPT6"
FT                   /id="PRO_0000410298"
FT   DOMAIN          1129..1201
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT   DOMAIN          1239..1349
FT                   /note="SH2"
FT   REGION          1..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1460..1506
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..60
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..123
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..164
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        165..194
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1506 AA;  171709 MW;  094A629765ED8110 CRC64;
     MSDRPGSASE GEGDEIRPYG EDRDSSEESE DDDPEEAKRI AEGFIVDEDE EDGEGEDDEE
     DEETRRRRRK EEKRRRKKER RMRREREEAE LSEDELELIE ENRGLREGRP LKRLRRRSGS
     EGSENDRAVP TLQDMFRDDE DRMEDDDDDL MDFIEEDEED EANQGETEEQ RRERKRAEKL
     KRREQARSRP ELTGVDRSSW DEIFAVFGDG QDYDWALEGE DGMDLDEEEE AAKKDLRLED
     VFDPAEIKAR RLQDEDKAVA NADRPERHQI VNSTLSDNPV FATDTLYPPP DFAAKWVAPK
     VSFRTQYLFY NQHPEGSYPI PTIDNPQPYP VYRRPDLEIE FEKAVSTALN MMFVQHLEVP
     YLWHYKRDVF SLLENQGQSS VLFLERDELW QVYVLGQRYR AIHERNEQTR QQWGKIKARK
     GDIEDEYFTK GLLGKACVAS IEAAGEGDEW LAYHYASDIK AIKEEEAFDE VSKKLPERAE
     REDIRRGRIM KLVEAFGIDA NKVASSFQDV HGQPAPVMNP DKMPLELADE FTGAAYSSPE
     QALSAASFVL VQELSKDPAI RQQARDFMDT CGLVTVNATD RGMSVIDQYH LYYNFKFLTN
     KPVPDFRDSP QFVHMLKAEE EGLINIAFDI REDMLASFTD ALIRCCRSND YGEIASAWNE
     VRMEVCNTLV KKHLMPMASK WIKEHLRTQA EEYIAERCRE ELELRVNVRP YASSGMEQGE
     TPSVLAITNG KGDIRDAVMA VMLDDEGNVR TQTKFDNLRD EEDKTMFIEL LEKRKPKVVV
     IGGFSAQTAR LKDAALVAIR QHAIELLGQN PPVSDAYPDH EGFQYAMAEY DEKLKAHLIP
     LIFVNDATAR LYMSSEEAEK EHPNLPLNGR YALGLARYAQ NPLNAYCKLG KHIASVTFME
     HHQKLIPQEK LLYHLERGLV NSVCFMGIEI NSCVADPYQR AMLPYIAGLG PRKADAVIYG
     IQKHGALINR MAFTDLGLFG PTIFENTAGF LTIESDLKDM MLEAENPQEQ PDPLDMTRIH
     PENYEFAQKM CQDALDLDVE DVADRHKSEV VQTLMLDDKR GKKLGELNLD DFAFNLQRQG
     EGNKRHTLGE IVSELIRYRS DRRPAFYVPT DWEIVTMVTG ETERTVGRGL KVTATVRKAI
     SARVFCQLES GLDAVLERDY VADEDQAPVT SCDEVFKPRQ AIKGVVIMPE PARFQVRIST
     RPSDLRQGVD FVQPFKDEEY NSKDRRDAAE AATAAKKQRR AGKVQRIVNH PNWHVLNSGQ
     AEQFLASQHR GDCVIRPSSK GPDRIAVTWK VDEDVYQHID VQEIDKPNEY SLGRILMVSG
     QYRYSDLDDL IINHVKATAR KFDEIQMHEK YKPEHELDAF LKNYVQAHPG RSIYGFSVDS
     DRPGYLKLCF LSKPTKDGGV IQTWPVRVLP GAYKLGNAIV PGVTELSNAF KMQYSEKLAE
     QGHQGKTPGI YLGKTPMHLG GRTPALGSRT PAMGSRTPAL GSRTPALGSR TPALGSRTPA
     QGGPRY