SPT6_CRYNJ
ID SPT6_CRYNJ Reviewed; 1506 AA.
AC P0CR72; Q55Y77; Q5KLR1;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Transcription elongation factor SPT6;
DE AltName: Full=Chromatin elongation factor SPT6;
GN Name=SPT6; OrderedLocusNames=CNB04370;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Plays a role in maintenance of chromatin structure during RNA
CC polymerase II transcription elongation thereby repressing transcription
CC initiation from cryptic promoters. Mediates the reassembly of
CC nucleosomes onto the promoters of at least a selected set of genes
CC during repression; the nucleosome reassembly is essential for
CC transcriptional repression (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SPT6 family. {ECO:0000305}.
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DR EMBL; AE017342; AAW41627.1; -; Genomic_DNA.
DR RefSeq; XP_568934.1; XM_568934.1.
DR AlphaFoldDB; P0CR72; -.
DR SMR; P0CR72; -.
DR STRING; 5207.AAW41627; -.
DR PaxDb; P0CR72; -.
DR EnsemblFungi; AAW41627; AAW41627; CNB04370.
DR GeneID; 3255639; -.
DR KEGG; cne:CNB04370; -.
DR VEuPathDB; FungiDB:CNB04370; -.
DR eggNOG; KOG1856; Eukaryota.
DR HOGENOM; CLU_001680_0_1_1; -.
DR InParanoid; P0CR72; -.
DR OMA; LCNGFKT; -.
DR OrthoDB; 56990at2759; -.
DR Proteomes; UP000002149; Chromosome 2.
DR GO; GO:0008023; C:transcription elongation factor complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR GO; GO:0042789; P:mRNA transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0034728; P:nucleosome organization; IBA:GO_Central.
DR GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR CDD; cd09928; SH2_Cterm_SPT6_like; 1.
DR CDD; cd09918; SH2_Nterm_SPT6_like; 1.
DR Gene3D; 1.10.10.2740; -; 1.
DR Gene3D; 1.10.10.650; -; 1.
DR Gene3D; 1.10.3500.10; -; 1.
DR Gene3D; 3.30.420.140; -; 1.
DR Gene3D; 3.30.505.10; -; 2.
DR InterPro; IPR041692; HHH_9.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR028083; Spt6_acidic_N_dom.
DR InterPro; IPR042066; Spt6_death-like.
DR InterPro; IPR032706; Spt6_HHH.
DR InterPro; IPR028088; Spt6_HTH_DNA-bd_dom.
DR InterPro; IPR035420; Spt6_SH2.
DR InterPro; IPR035018; Spt6_SH2_C.
DR InterPro; IPR035019; Spt6_SH2_N.
DR InterPro; IPR028231; Spt6_YqgF.
DR InterPro; IPR023323; Tex-like_dom_sf.
DR InterPro; IPR023319; Tex-like_HTH_dom_sf.
DR InterPro; IPR017072; TF_Spt6.
DR InterPro; IPR037027; YqgF/RNaseH-like_dom_sf.
DR PANTHER; PTHR10145; PTHR10145; 1.
DR Pfam; PF14635; HHH_7; 1.
DR Pfam; PF17674; HHH_9; 1.
DR Pfam; PF14641; HTH_44; 1.
DR Pfam; PF14633; SH2_2; 1.
DR Pfam; PF14632; SPT6_acidic; 1.
DR Pfam; PF14639; YqgF; 2.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF47781; SSF47781; 2.
DR SUPFAM; SSF53098; SSF53098; 1.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; SH2 domain; Transcription;
KW Transcription regulation.
FT CHAIN 1..1506
FT /note="Transcription elongation factor SPT6"
FT /id="PRO_0000238573"
FT DOMAIN 1129..1201
FT /note="S1 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 1239..1349
FT /note="SH2"
FT REGION 1..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1460..1506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..60
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..123
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..164
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1506 AA; 171725 MW; A25EFBA9D7CBE438 CRC64;
MSDRPGSASE GEGDEIRPYG EDRDSSEESE DDDPEEAKRI AEGFIVDEDE EDGEGEDDEE
DEETRRRRRK EEKRRRKKER RMRREREEAE LSEDELELIE ENRGLREGRP LKRLRRRSGS
EGSENDRAVP TLQDMFRDDE DRMEDDDDDL MDFIEEDEED EANQGETEEQ RRERKRAEKL
KRREQARSRP ELTGVDRSSW DEIFAVFGDG QDYDWALEGE DGMDLDEEEE AAKKDLRLED
VFDPAEIKAR RLQDEDKAVA NADRPERHQI VNSTLSDNPV FATDTLYPPP DFAAKWVAPK
VSFRTQYLFY NQHPEGSYPI PTIDNPQPYP VYRRPDLEIE FEKAVSTALN MMFVQHLEVP
YLWHYKRDVF SLLENQGQSS VLFLERDELW QVYVLGQRYR AIHERNEQTR QQWGKIKARK
GDIEDEYFTK GLLGKACVAS IEAAGEGDEW LAYHYASDIK AIKEEEAFDE VSKKLPERAE
REDIRRGRIM KLVEAFGIDA NKVASSFQDV HGQPAPVMNP DKMPLELADE FTGAAYSSPE
QALSAASFVL VQELSKDPAI RQQARDFMDT CGLVTVNATD RGMSVIDQYH LYYNFKFLTN
KPVLDFRDSP QFVHMLKAEE EGLINIAFDI REDMLASFTD ALIRCCRSND YGEIASAWNE
VRMEVCNTLV KKHLMPMASK WIKEHLRTQA EEYIAERCRE ELELRVNVRP YASSGMEQGE
TPSVLAITNG KGDIRDAVMA VMLDDEGNVR TQTKFDNLRD EEDKTMFIEL LEKRKPKVVV
IGGFSAQTAR LKDAALVAIR QHAIELLGQN PPVSDAYPDH EGFQYAMAEY DEKLKAHLIP
LIFVNDATAR LYMSSEEAEK EHPNLPLNGR YALGLARYAQ NPLNAYCKLG KHIASVTFME
HHQKLIPQEK LLYHLERGLV NSVCFMGIEI NSCVADPYQR AMLPYIAGLG PRKADAVIYG
IQKHGALINR MAFTDLGLFG PTIFENTAGF LTIESDLKDM MLEAENPQEQ PDPLDMTRIH
PENYEFAQKM CQDALDLDVE DVADRHKSEV VQTLMLDDKR GKKLGELNLD DFAFNLQRQG
EGNKRHTLGE IVSELIRYRS DRRPAFYVPT DWEIVTMVTG ETERTVGRGL KVTATVRKAI
SARVFCQLES GLDAVLERDY VADEDQAPVT SCDEVFKPRQ AIKGVVIMPE PARFQVRIST
RPSDLRQGVD FVQPFKDEEY NSKDRRDAAE AATAAKKQRR AGKVQRIVNH PNWHVLNSGQ
AEQFLASQHR GDCVIRPSSK GPDRIAVTWK VDEDVYQHID VQEIDKPNEY SLGRILMVSG
QYRYSDLDDL IINHVKATAR KFDEIQMHEK YKPEHELDAF LKNYVQAHPG RSIYGFSVDS
DRPGYLKLCF LSKPTKDGGV IQTWPVRVLP GAYKLGNAIV PGVTELSNAF KMQYSEKLAE
QGHQGKTPGI YLGKTPMHLG GRTPALGSRT PAMGSRTPAL GSRTPALGSR TPALGSRTPA
QGGPRY
