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SPT6_DEBHA
ID   SPT6_DEBHA              Reviewed;        1439 AA.
AC   Q6BVE1;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Transcription elongation factor SPT6;
DE   AltName: Full=Chromatin elongation factor SPT6;
GN   Name=SPT6; OrderedLocusNames=DEHA2C03344g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Plays a role in maintenance of chromatin structure during RNA
CC       polymerase II transcription elongation thereby repressing transcription
CC       initiation from cryptic promoters. Mediates the reassembly of
CC       nucleosomes onto the promoters of at least a selected set of genes
CC       during repression; the nucleosome reassembly is essential for
CC       transcriptional repression (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPT6 family. {ECO:0000305}.
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DR   EMBL; CR382135; CAG85873.1; -; Genomic_DNA.
DR   RefSeq; XP_457828.1; XM_457828.1.
DR   AlphaFoldDB; Q6BVE1; -.
DR   SMR; Q6BVE1; -.
DR   STRING; 4959.XP_457828.1; -.
DR   PRIDE; Q6BVE1; -.
DR   EnsemblFungi; CAG85873; CAG85873; DEHA2C03344g.
DR   GeneID; 2900117; -.
DR   KEGG; dha:DEHA2C03344g; -.
DR   VEuPathDB; FungiDB:DEHA2C03344g; -.
DR   eggNOG; KOG1856; Eukaryota.
DR   HOGENOM; CLU_001680_0_1_1; -.
DR   InParanoid; Q6BVE1; -.
DR   OMA; LCNGFKT; -.
DR   OrthoDB; 56990at2759; -.
DR   Proteomes; UP000000599; Chromosome C.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR   GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:InterPro.
DR   CDD; cd09928; SH2_Cterm_SPT6_like; 1.
DR   CDD; cd09918; SH2_Nterm_SPT6_like; 1.
DR   Gene3D; 1.10.10.2740; -; 1.
DR   Gene3D; 1.10.10.650; -; 1.
DR   Gene3D; 1.10.3500.10; -; 1.
DR   Gene3D; 3.30.420.140; -; 1.
DR   Gene3D; 3.30.505.10; -; 2.
DR   InterPro; IPR041692; HHH_9.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR028083; Spt6_acidic_N_dom.
DR   InterPro; IPR042066; Spt6_death-like.
DR   InterPro; IPR032706; Spt6_HHH.
DR   InterPro; IPR028088; Spt6_HTH_DNA-bd_dom.
DR   InterPro; IPR035420; Spt6_SH2.
DR   InterPro; IPR035018; Spt6_SH2_C.
DR   InterPro; IPR035019; Spt6_SH2_N.
DR   InterPro; IPR028231; Spt6_YqgF.
DR   InterPro; IPR023323; Tex-like_dom_sf.
DR   InterPro; IPR023319; Tex-like_HTH_dom_sf.
DR   InterPro; IPR017072; TF_Spt6.
DR   InterPro; IPR037027; YqgF/RNaseH-like_dom_sf.
DR   PANTHER; PTHR10145; PTHR10145; 1.
DR   Pfam; PF14635; HHH_7; 1.
DR   Pfam; PF17674; HHH_9; 1.
DR   Pfam; PF14641; HTH_44; 1.
DR   Pfam; PF14633; SH2_2; 1.
DR   Pfam; PF14632; SPT6_acidic; 1.
DR   Pfam; PF14639; YqgF; 1.
DR   PIRSF; PIRSF036947; Spt6; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF47781; SSF47781; 2.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; SH2 domain; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1439
FT                   /note="Transcription elongation factor SPT6"
FT                   /id="PRO_0000238574"
FT   DOMAIN          1229..1323
FT                   /note="SH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT   REGION          1..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1417..1439
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..42
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..63
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..131
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        150..164
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        165..180
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..206
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1420..1439
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1439 AA;  165357 MW;  A13AF34BE516E104 CRC64;
     MAKEDIEEER EIRNDASENS SDEEGDDVLD SSEEDDDDDD EEAIKRVREG FIVDDDEDES
     QKRKRRKHKK RKREERTNDD ENNALDQDDL ELLMENSGAR PQPSSNKLKR LKRAYTEDTE
     GAEEEEIGAK SGRGGLTDIF SDEDNNEEER ADLGETRVDD DRNILDEFED FIEEDEYSDE
     DEERQRKLTQ QRERAQKKGP RLDTSKLSNV DRESLQQLFE VFGNGAEYEW ALEAQEMEDE
     GNGENLEPTS LDEVFEHAEL KERMLTEEDN LIRIVDIPER FQKYRANLNY IDLEGEELKS
     EQGWVANILF MEKQGSFSGF LEEPFKEAVS KVVEFISKDV YEVPFIWTHR RDFLLYSEEI
     KNEDGSVTNS VHKLLFEDDL WRIFQLDIEY HSLYEKRVNI EKLIESLNLD DDLVKDVKSL
     ETMVAIQDLQ DYINFTYSTE IRKLYDDKET EGIDANITKK HSKYAIFERI KSNVLYDAVN
     AFGISAKEFG ENVQDQSSKK FEVPYRIHAT DDHIESPEDL IERLCEDDEV LFKDPKNALN
     AVRKTFAEEI FHNPKIRHEV RTTFKDFASI RVAVTEKGKA IDNHSPYADI KYAINRSPAD
     LVRNPDVLLR MLEAEAAGLV VVKVETKDYD SWFQCIFNCL KSDGSSEIFE KWNKEREFVL
     NMAFKRLTSM VSMNTKEDLR RECERLIASE VRRRFLARID QAPFTPFGFD KGTKPNVLAL
     SFGKGDFDSA VIGAFLRESG KVDEFFKSED NPIRDRESED KFSGQLKEFF DKNLRNQKPD
     VIVVSGYNAI SKKLFDSVKS FVETNNVTAN TEELTDVQNP PLIQVIWGQS ETATLFQNSE
     RARIEFSDKP TLAKYCVGLA RYVQSPLLEY LSLGEGILSL TFFEHQKLIS TDLVMEAIES
     AYVDIINMVG VEINEAIRDP YIAQLLPYVA GLGPRKASGL LRNINSKLGS TLANRSDLIE
     NELSTANIFI NCSSFLNIPY DEGLSMRDSS VELLDATRIH PEDYDLARKM AADALDLDEE
     DMAHVEEQGG IIYQLMQDGV NKVDDLNLTA YGKELESKFG KKKYATLQSI KEELVNNFEE
     IRRSFHILES HEVFHMLTGE TTESFTRNTI VPVTVNKVGQ NFRDFENSKI KFAKVTTSSF
     IQGNIEEASI PQGIDLAQGQ VVQAVVLDAY YDSFTASFSL LEADIQKGAA PKFHKDPLKW
     NFEAEQADKQ KEMAKERAQL AKTRNIQHPL FHNFSYKQAE EFLAPQAVGD CVLRPSSKGP
     NYLTVTWKVS NNLFQHLSIQ ENTQGMGKEY IVEHKKYADL DQLIFQHVQA IAKHVDEMCR
     HPKFREGTMS EVNEWLESYT KANPKNSAYV FCFDHKAPGW FLLLFKVNVN TPITTWHVKT
     ECDGYRLKGF SYPSMLRLCN GFKQTFKSYV KGIADRSRST KPAPVNNQAQ ASTYGGYGY
 
 
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