SPT6_KLULA
ID SPT6_KLULA Reviewed; 1460 AA.
AC Q6CVK3;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Transcription elongation factor SPT6;
DE AltName: Full=Chromatin elongation factor SPT6;
GN Name=SPT6; OrderedLocusNames=KLLA0B11385g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Plays a role in maintenance of chromatin structure during RNA
CC polymerase II transcription elongation thereby repressing transcription
CC initiation from cryptic promoters. Mediates the reassembly of
CC nucleosomes onto the promoters of at least a selected set of genes
CC during repression; the nucleosome reassembly is essential for
CC transcriptional repression (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SPT6 family. {ECO:0000305}.
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DR EMBL; CR382122; CAH02429.1; -; Genomic_DNA.
DR RefSeq; XP_452036.1; XM_452036.1.
DR AlphaFoldDB; Q6CVK3; -.
DR SMR; Q6CVK3; -.
DR STRING; 28985.XP_452036.1; -.
DR EnsemblFungi; CAH02429; CAH02429; KLLA0_B11385g.
DR GeneID; 2897509; -.
DR KEGG; kla:KLLA0_B11385g; -.
DR eggNOG; KOG1856; Eukaryota.
DR HOGENOM; CLU_001680_0_1_1; -.
DR InParanoid; Q6CVK3; -.
DR OMA; LCNGFKT; -.
DR Proteomes; UP000000598; Chromosome B.
DR GO; GO:0000791; C:euchromatin; IEA:EnsemblFungi.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005721; C:pericentric heterochromatin; IEA:EnsemblFungi.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0042393; F:histone binding; IEA:EnsemblFungi.
DR GO; GO:0031491; F:nucleosome binding; IEA:EnsemblFungi.
DR GO; GO:0001073; F:transcription antitermination factor activity, DNA binding; IEA:EnsemblFungi.
DR GO; GO:0000433; P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose; IEA:EnsemblFungi.
DR GO; GO:0140673; P:co-transcriptional chromatin reassembly; IEA:EnsemblFungi.
DR GO; GO:0042789; P:mRNA transcription by RNA polymerase II; IEA:EnsemblFungi.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR GO; GO:0006334; P:nucleosome assembly; IEA:EnsemblFungi.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:EnsemblFungi.
DR GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR GO; GO:0071931; P:positive regulation of transcription involved in G1/S transition of mitotic cell cycle; IEA:EnsemblFungi.
DR GO; GO:0000414; P:regulation of histone H3-K36 methylation; IEA:EnsemblFungi.
DR GO; GO:0031440; P:regulation of mRNA 3'-end processing; IEA:EnsemblFungi.
DR GO; GO:0043618; P:regulation of transcription from RNA polymerase II promoter in response to stress; IEA:EnsemblFungi.
DR GO; GO:0001178; P:regulation of transcriptional start site selection at RNA polymerase II promoter; IEA:EnsemblFungi.
DR CDD; cd09928; SH2_Cterm_SPT6_like; 1.
DR CDD; cd09918; SH2_Nterm_SPT6_like; 1.
DR Gene3D; 1.10.10.2740; -; 1.
DR Gene3D; 1.10.10.650; -; 1.
DR Gene3D; 1.10.3500.10; -; 1.
DR Gene3D; 3.30.420.140; -; 1.
DR Gene3D; 3.30.505.10; -; 2.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR028083; Spt6_acidic_N_dom.
DR InterPro; IPR042066; Spt6_death-like.
DR InterPro; IPR032706; Spt6_HHH.
DR InterPro; IPR028088; Spt6_HTH_DNA-bd_dom.
DR InterPro; IPR035420; Spt6_SH2.
DR InterPro; IPR035018; Spt6_SH2_C.
DR InterPro; IPR035019; Spt6_SH2_N.
DR InterPro; IPR028231; Spt6_YqgF.
DR InterPro; IPR023323; Tex-like_dom_sf.
DR InterPro; IPR023319; Tex-like_HTH_dom_sf.
DR InterPro; IPR017072; TF_Spt6.
DR InterPro; IPR006641; YqgF/RNaseH-like_dom.
DR InterPro; IPR037027; YqgF/RNaseH-like_dom_sf.
DR PANTHER; PTHR10145; PTHR10145; 1.
DR Pfam; PF14635; HHH_7; 1.
DR Pfam; PF14641; HTH_44; 1.
DR Pfam; PF14633; SH2_2; 1.
DR Pfam; PF14632; SPT6_acidic; 1.
DR Pfam; PF14639; YqgF; 1.
DR PIRSF; PIRSF036947; Spt6; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00732; YqgFc; 1.
DR SUPFAM; SSF47781; SSF47781; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; SH2 domain; Transcription;
KW Transcription regulation.
FT CHAIN 1..1460
FT /note="Transcription elongation factor SPT6"
FT /id="PRO_0000238577"
FT DOMAIN 1257..1354
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT REGION 1..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..61
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..282
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1460 AA; 169610 MW; 188534D121A1B8DE CRC64;
MSDKEDEKQS QPVLKDDKQD QTEEPAIDDN VNGDEGPSDE EEGDDVFDSS EEDEDLDNDE
EEAQKVREGF IVDDDEEGGE EDEVVKKKSR RKRRAREEEN EALDEDDLDL LMENAGFKRP
SASEAAKQRS GKLKRLKRVG DDEEESASAE PESEVARTNK LDDFFSEEEE EEELEDDGTG
RAPSRKGVEK TVTLADDMDD FIEEDEFSDE DEEARKFRIA EKKRIKEQRL AQPTQITGLS
PDKVDEMFEV FGDGHDYDWA LELENEEELD RLEESSENEQ DENELGIDSK RKKKLTLQDI
YDLQDLKKNL LTEEDMNIRK ADIPERYQEL RTGLKNYGKL SPEDLELEKN WISDKIAVDK
NFDADYDTTE FKEAIGNAIN FIQQENLEVS FIYAYRRNYI SSRSKDGFVL IEDDLWDIVF
YDTEFHSIIY KRDYVKTFYE KLDIHDPIVD EYFSNQSMTE LNSLQDIYDY VEFKYAQEIN
DVLLSTQQDA TSKKHLKNSS YEKFKASALY QAINDTGITA EQVGENISAE HQLHPVVDHP
SLKPTDSVAN ILEGPEAKDL QIFSQNPKLA LETIEKYYAL ELSKNPKVRQ KIRDDFYKYY
IVDVALTSKG RKEIQRGSPY EDIKYALGRT PAHFRSEPDV FLRMLEAESL HLMNIQIHVS
SQDQYTNHLF QTSLETSNTS EIASEWNSFR RDAFDSALNK VFSDVSQEIK DELKKTCLRL
VTKSVRHQFM FKLDQAPFIP NPKDPKIPRV LTITCGQGKF GSDAIIAVYL NRKTEFVRDY
KIVENPFDRK EPELFENALD DIIQHCQPNV IGINGPNPST QRLYKKIQEI VQKKQIVDNR
GSHVPVIYVE DEVAVRYQSS ERAAQEFPSK PTLVKYCIAL GRYIHSPLLE YANLTNEELL
SLSIHSHQSL LTRELFLQAL ETSFVDIVNL VGIEVNKATD NHYYAKALRY IAGFGRRKSA
DFLESLQRLN EPLLARQQLI THDILTKTIF MNSAAFLYIS WNEKNQRYED LEHDQLDGTR
IHPEDYHLAT KVAADALEFD PDAIAEKEEQ GTMSEFIELL REDPDRRTKL ESLNLEAYAE
ELEKNTGQRK LNNLNTIVLE LLEGFEELRN DFHPLHGDEV FKSLTGESEK TFFKGCIIPV
RVERFRHNDI YGVTNSGVEC VINAQRHIGA QLKRPAEEVY EIGKTYPAKV IYIDYDNISC
EVSLLEHDIR RQYVPIHYSK DPSIWNVEQE MKDQEIEKKL ALEEARAKRT HRVINHPYYG
NFTGPQAEDY LRSRERGDFV IRQSSRGDDH LAITWKLDKD LFQHVDILEK DKENPLALGK
TLIVEDQKYH DLDQIIVEYL QNKVRLLNEI TSNEKFKKGT KKEVIKFIED YSKVNPNRSV
YYFSFNYEHP GWFYLMFKIN AQSQLYVWNV KLTHTGFFLV NYNYPTVIQL CNGFKTLLKS
SSRNKTQDNN NNNSGGYYGY
