SPT6_USTMA
ID SPT6_USTMA Reviewed; 1723 AA.
AC Q4PI89; A0A0D1E757;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Transcription elongation factor SPT6;
DE AltName: Full=Chromatin elongation factor SPT6;
GN Name=SPT6; ORFNames=UMAG_00174;
OS Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=237631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=521 / FGSC 9021;
RX PubMed=17080091; DOI=10.1038/nature05248;
RA Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA Birren B.W.;
RT "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT maydis.";
RL Nature 444:97-101(2006).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=521 / FGSC 9021;
RA Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in maintenance of chromatin structure during RNA
CC polymerase II transcription elongation thereby repressing transcription
CC initiation from cryptic promoters. Mediates the reassembly of
CC nucleosomes onto the promoters of at least a selected set of genes
CC during repression; the nucleosome reassembly is essential for
CC transcriptional repression (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SPT6 family. {ECO:0000305}.
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DR EMBL; CM003140; KIS71739.1; -; Genomic_DNA.
DR RefSeq; XP_011386117.1; XM_011387815.1.
DR AlphaFoldDB; Q4PI89; -.
DR SMR; Q4PI89; -.
DR STRING; 5270.UM00174P0; -.
DR PRIDE; Q4PI89; -.
DR EnsemblFungi; KIS71739; KIS71739; UMAG_00174.
DR GeneID; 23561550; -.
DR KEGG; uma:UMAG_00174; -.
DR VEuPathDB; FungiDB:UMAG_00174; -.
DR eggNOG; KOG1856; Eukaryota.
DR HOGENOM; CLU_001680_0_1_1; -.
DR InParanoid; Q4PI89; -.
DR OMA; LCNGFKT; -.
DR OrthoDB; 56990at2759; -.
DR Proteomes; UP000000561; Chromosome 1.
DR GO; GO:0008023; C:transcription elongation factor complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR GO; GO:0042789; P:mRNA transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0034728; P:nucleosome organization; IBA:GO_Central.
DR GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR CDD; cd09928; SH2_Cterm_SPT6_like; 1.
DR CDD; cd09918; SH2_Nterm_SPT6_like; 1.
DR Gene3D; 1.10.10.2740; -; 1.
DR Gene3D; 1.10.10.650; -; 1.
DR Gene3D; 1.10.3500.10; -; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 3.30.420.140; -; 1.
DR Gene3D; 3.30.505.10; -; 2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR028083; Spt6_acidic_N_dom.
DR InterPro; IPR042066; Spt6_death-like.
DR InterPro; IPR032706; Spt6_HHH.
DR InterPro; IPR028088; Spt6_HTH_DNA-bd_dom.
DR InterPro; IPR035420; Spt6_SH2.
DR InterPro; IPR035018; Spt6_SH2_C.
DR InterPro; IPR035019; Spt6_SH2_N.
DR InterPro; IPR028231; Spt6_YqgF.
DR InterPro; IPR023323; Tex-like_dom_sf.
DR InterPro; IPR023319; Tex-like_HTH_dom_sf.
DR InterPro; IPR017072; TF_Spt6.
DR InterPro; IPR037027; YqgF/RNaseH-like_dom_sf.
DR PANTHER; PTHR10145; PTHR10145; 1.
DR Pfam; PF14635; HHH_7; 1.
DR Pfam; PF14641; HTH_44; 1.
DR Pfam; PF14633; SH2_2; 1.
DR Pfam; PF14632; SPT6_acidic; 1.
DR Pfam; PF14639; YqgF; 1.
DR PIRSF; PIRSF036947; Spt6; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF47781; SSF47781; 2.
DR SUPFAM; SSF53098; SSF53098; 1.
DR SUPFAM; SSF55550; SSF55550; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; SH2 domain; Transcription;
KW Transcription regulation.
FT CHAIN 1..1723
FT /note="Transcription elongation factor SPT6"
FT /id="PRO_0000238579"
FT DOMAIN 1363..1445
FT /note="SH2"
FT REGION 1..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1632..1723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..130
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..218
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1636..1653
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1670..1686
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1723 AA; 193945 MW; 8294D04DDDC2B78A CRC64;
MADEERVPAP YFQDDEEGGA SDEGEGVDLI KSHGNLVGSG GEDSSDEEED DDPEEARRVA
EGFIAEDDEE EEEDSEARRD RRRRRKKKRK QNEQDFEVDE DDLELLAENT GQPRRKEAGR
LKRFRRGSAS PPADDEAAAR QRTLDQIFED DDEDEDDIRS GRRGVNYDDD DEDLPSVGQA
LRAGVARKQR EVVGAYEDDG LDDFIEEDED DEEMQGLDEE EREARRQQRR EEKRKARLSG
SAADPAKAGI DHEAWDEIHE IFGNGEDYFW ALEDEEEDAF DEEKKNKMEY KDIFEPAQIA
ERMLTEDDER IKRIDIPERL QLACPGEEGL KLLERKLTDT ELFEAAKWAS TRISQRTAAE
FLDEAGLFHR QRSEFINAVQ LMLSYMLNDL LEVPFLFQHR FDELEHLTFD EVERQYRSID
LLTRRELYTL SGLGLKFKTL LVRKDQLRAT FNKIHVDVKT EPIQDDELDG GLDAMPADES
RAARVESSQR QRAIFEDMLA QAASLEEISD ITEYLTLRYG QQMRDAQALT SNGTDQAASD
LQGLTLTSDP LVSATPAFKK PSLVGQYERN KKTVLAELAK KFGITSDELA SNVTSHTRQY
SPRDPEESPF KFAEQFTGSA WGAHSPEIAL AKAKMMLSQE IGKDPILKRE MRQLFKDAAE
INIEPTERGM TVIDDQHPYA NFKFIANKPA RLVPQNPSQY LQMLQAEDEL LIKLDIDLKD
VVLTRFEARL YNNYASEGVG ELSNAWNEQR RDVIREALKT HLVPNGRIWL KEFLREESRE
TLLRHVDVLM TKRVQEGPFM SKSMMARNRD PKIEEEDRIP RVLAVSHGGG DPRKDVVQAV
YLDERGRFRE HATFDDLRPL SARQMQEREL ELERTRGKAE FVDHRADFVK LLKQRRPDIV
VVSGWSVRTA ELKRHVQELA DTAHQEICDA DRLHSDLERD QAVIDVVTCH DDVARIYQHS
SRAAEEFPEL SELGRYCLAL ARYAQSPVNE FAALGSDLTA VILDPNQRLL PQDRLRLHFE
RCIGAVVNEN GVEINQAMTS TYLQTMLPFV AGLGPRKAHA LVNAISTKLE GTLINRTLLI
SRNILTFQVF QNCASFLRIE QDMLLEADED DVPDVLDSTR IHPEDYDFPR KMAADALNKH
EEDLEGEHPS LPCKELMEDA DPADKLNTLD LDNYATMLFE RKGERKRATL HSCRTELIKP
YDDLREKQSE PSLEEMLTMF TGETSKTLAE GFVVSVEVTR VQEGNRMQEG HIKCRLDSGI
EGTIEAEHAV EHYTPGSVRL RDLVRPQQTL DALVRKIDYK MCTVQLSISP WELQHRATHQ
GKTPIDIKFY DRRKADQWNE HAAAKAKLRI QARRQNRVID HPNYHNFNYK AAVTFLRSQP
RGTVVVRPSS KGDDHLAVTW KVDDDVYQNI DVTELDKESE YSLGRVLRIE GMGSYSDLDE
LIVNHVKPMV HMVEMMMNHE KYKGADEEDL HRFLTNWSLA NPSRSVYAFG LNKDRPGYFN
LSFKANRDAA IQTWPVKVLP NAFKLGPADQ LADVAALCNA FKTQYTTQAS MARGAKTPYG
GGRTPAPGMG GATPLGGRTP YGGVRNGMAG SATPGQGVAG GYTTPMINVA SATPNPYGGA
YGRNGAAGGY GAPAAGGPPG RPPSMPGAPP MMPPGMASGG GAPSYAPPFA GAGEPGPPPA
RPPVPHGMHP DRFAQAEYGG ASQQSYGENS GGAGGYGGGY RGY
