SPTA3_HUMAN
ID SPTA3_HUMAN Reviewed; 192 AA.
AC Q8NHX4; Q86WX5; Q8N9Y6;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Spermatogenesis-associated protein 3;
DE AltName: Full=Testis and spermatogenesis cell-related protein 1;
DE AltName: Full=Testis spermatocyte apoptosis-related protein 1;
GN Name=SPATA3; Synonyms=TSARG1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT DEL SER-41--49-PRO.
RC TISSUE=Testis;
RX PubMed=12812072;
RA Fu J.J., Lu G.X., Li L.Y., Liu G., Xing X.W., Liu S.F.;
RT "Molecular cloning for testis spermatogenesis cell apoptosis related gene
RT TSARG1 and Mtsarg1 and expression analysis for Mtsarg1 gene.";
RL Yi Chuan Xue Bao 30:25-29(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT DEL SER-41--49-PRO.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AY032925; AAK54455.1; -; mRNA.
DR EMBL; AK093385; BAC04149.1; -; mRNA.
DR EMBL; AC009407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC105344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC047704; AAH47704.1; -; mRNA.
DR CCDS; CCDS2481.1; -.
DR RefSeq; NP_620712.2; NM_139073.3.
DR RefSeq; XP_005246360.1; XM_005246303.2.
DR RefSeq; XP_016858852.1; XM_017003363.1.
DR AlphaFoldDB; Q8NHX4; -.
DR BioGRID; 126241; 22.
DR STRING; 9606.ENSP00000388895; -.
DR iPTMnet; Q8NHX4; -.
DR PhosphoSitePlus; Q8NHX4; -.
DR BioMuta; SPATA3; -.
DR DMDM; 41704647; -.
DR MassIVE; Q8NHX4; -.
DR PaxDb; Q8NHX4; -.
DR PeptideAtlas; Q8NHX4; -.
DR PRIDE; Q8NHX4; -.
DR Antibodypedia; 11837; 50 antibodies from 21 providers.
DR DNASU; 130560; -.
DR Ensembl; ENST00000424440.5; ENSP00000399514.1; ENSG00000173699.17.
DR Ensembl; ENST00000433428.6; ENSP00000403804.2; ENSG00000173699.17.
DR Ensembl; ENST00000452881.5; ENSP00000388895.1; ENSG00000173699.17.
DR Ensembl; ENST00000455816.1; ENSP00000388741.1; ENSG00000173699.17.
DR GeneID; 130560; -.
DR KEGG; hsa:130560; -.
DR MANE-Select; ENST00000433428.7; ENSP00000403804.2; NM_139073.5; NP_620712.2.
DR UCSC; uc002vri.5; human.
DR CTD; 130560; -.
DR DisGeNET; 130560; -.
DR GeneCards; SPATA3; -.
DR HGNC; HGNC:17884; SPATA3.
DR HPA; ENSG00000173699; Tissue enriched (testis).
DR MIM; 619857; gene.
DR neXtProt; NX_Q8NHX4; -.
DR OpenTargets; ENSG00000173699; -.
DR PharmGKB; PA38256; -.
DR VEuPathDB; HostDB:ENSG00000173699; -.
DR eggNOG; ENOG502TDUQ; Eukaryota.
DR GeneTree; ENSGT00390000003032; -.
DR HOGENOM; CLU_099077_0_0_1; -.
DR InParanoid; Q8NHX4; -.
DR OMA; PRDCGCG; -.
DR OrthoDB; 1513172at2759; -.
DR PhylomeDB; Q8NHX4; -.
DR TreeFam; TF338040; -.
DR PathwayCommons; Q8NHX4; -.
DR BioGRID-ORCS; 130560; 14 hits in 1065 CRISPR screens.
DR ChiTaRS; SPATA3; human.
DR GenomeRNAi; 130560; -.
DR Pharos; Q8NHX4; Tdark.
DR PRO; PR:Q8NHX4; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8NHX4; protein.
DR Bgee; ENSG00000173699; Expressed in sperm and 113 other tissues.
DR ExpressionAtlas; Q8NHX4; baseline and differential.
DR Genevisible; Q8NHX4; HS.
DR InterPro; IPR026717; SPATA3.
DR PANTHER; PTHR22234; PTHR22234; 1.
DR Pfam; PF15662; SPATA3; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..192
FT /note="Spermatogenesis-associated protein 3"
FT /id="PRO_0000072174"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..49
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 41..49
FT /note="Missing"
FT /id="VAR_070808"
FT CONFLICT 104
FT /note="I -> T (in Ref. 4; AAH47704)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 192 AA; 20901 MW; CC2E2B60D4A2CD11 CRC64;
MKKVKKKRSE ARRHRDSTSQ HASSNSTSQQ PSPESTPQQP SPESTPQQPS PESTPQHSSL
ETTSRQPAFQ ALPAPEIRRS SCCLLSPDAN VKAAPQSRKA GPLIRAGPHS CSCATCPCSS
ACWRRLGLCH SRIFDVLLPR DWQMAPGRGL PNLLTFYRKS SRKPSSHRNA CPPSPRNCGC
GSGGSRSCLL HH
