SPTF1_CAEEL
ID SPTF1_CAEEL Reviewed; 298 AA.
AC Q93727; Q564X9;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Specificity protein transcription factor 1 {ECO:0000303|PubMed:25769980};
GN Name=sptf-1 {ECO:0000312|WormBase:F45H11.1a};
GN ORFNames=F45H11.1 {ECO:0000312|WormBase:F45H11.1a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=25769980; DOI=10.1534/genetics.115.176172;
RA Gonzalez-Barrios M., Fierro-Gonzalez J.C., Krpelanova E., Mora-Lorca J.A.,
RA Pedrajas J.R., Penate X., Chavez S., Swoboda P., Jansen G.,
RA Miranda-Vizuete A.;
RT "Cis- and trans-regulatory mechanisms of gene expression in the ASJ sensory
RT neuron of Caenorhabditis elegans.";
RL Genetics 200:123-134(2015).
CC -!- FUNCTION: Probable transcription factor which modulates gene
CC expression, thereby acting as an ASJ sensory neuron terminal selector
CC gene. {ECO:0000269|PubMed:25769980}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:F45H11.1a};
CC IsoId=Q93727-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:F45H11.1b};
CC IsoId=Q93727-2; Sequence=VSP_061148;
CC -!- TISSUE SPECIFICITY: Expressed in ASJ sensory neurons, pharyngeal cells,
CC rectal cells, intestine, seam cells, and vulval cells.
CC {ECO:0000269|PubMed:25769980}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown abolishes expression of
CC sulfotransferase ssu-1 and thioredoxin trx-1 in the ASJ sensory
CC neurons, in adults, embryos and larvae. {ECO:0000269|PubMed:25769980}.
CC -!- SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
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DR EMBL; BX284601; CAB01709.1; -; Genomic_DNA.
DR EMBL; BX284601; CAI79244.1; -; Genomic_DNA.
DR PIR; T22250; T22250.
DR RefSeq; NP_001021465.1; NM_001026294.2.
DR AlphaFoldDB; Q93727; -.
DR STRING; 6239.F45H11.1a; -.
DR PaxDb; Q93727; -.
DR EnsemblMetazoa; F45H11.1a.1; F45H11.1a.1; WBGene00009743. [Q93727-1]
DR EnsemblMetazoa; F45H11.1b.1; F45H11.1b.1; WBGene00009743. [Q93727-2]
DR EnsemblMetazoa; F45H11.1b.2; F45H11.1b.2; WBGene00009743. [Q93727-2]
DR GeneID; 172909; -.
DR KEGG; cel:CELE_F45H11.1; -.
DR UCSC; F45H11.1b; c. elegans.
DR CTD; 172909; -.
DR WormBase; F45H11.1a; CE16055; WBGene00009743; sptf-1.
DR WormBase; F45H11.1b; CE38353; WBGene00009743; sptf-1.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161293; -.
DR HOGENOM; CLU_1062772_0_0_1; -.
DR InParanoid; Q93727; -.
DR OMA; ANKCECP; -.
DR OrthoDB; 1597252at2759; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00009743; Expressed in embryo and 3 other tissues.
DR ExpressionAtlas; Q93727; baseline and differential.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IMP:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Metal-binding; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..298
FT /note="Specificity protein transcription factor 1"
FT /id="PRO_0000453459"
FT ZN_FING 260..284
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 206..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 291..298
FT /note="KKRSGDSS -> VRKPV (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_061148"
SQ SEQUENCE 298 AA; 31722 MW; F83E5FE550757527 CRC64;
MGGASSPRIP SRRSAPYFTS LAFFGSSYIK VKNNRNKMLN PTDAASVALS FSVPFQMSGE
NPLSKLVEHC NKFVPGADIK MKAEPAKPES LLLPTDMNAY SPYLATPNWW VDQTGWPQLY
PTVTTASSVD VYQNYLASSQ LGGLLSSSVS AVASQLPAGI NAQSALNITS QQRTIAKSFQ
HTKPMASSSS IPSVLTASNS SANSLVSSGS ESVSARGTSG SGGTGKYPSS RTANKCECPN
CHEIEKFGPN AIAARKRGVH NCHIAGCGKV YNKSSHLKAH LRWHSGERQM KKRSGDSS
