SPTF2_CAEEL
ID SPTF2_CAEEL Reviewed; 166 AA.
AC Q22678;
DT 25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Specificity protein transcription factor 2 {ECO:0000312|WormBase:T22C8.5};
GN Name=sptf-2 {ECO:0000312|WormBase:T22C8.5};
GN ORFNames=T22C8.5 {ECO:0000312|WormBase:T22C8.5};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=24569038; DOI=10.1534/g3.113.009522;
RA Jackson B.M., Abete-Luzi P., Krause M.W., Eisenmann D.M.;
RT "Use of an activated beta-catenin to identify Wnt pathway target genes in
RT caenorhabditis elegans, including a subset of collagen genes expressed in
RT late larval development.";
RL G3 (Bethesda) 4:733-747(2014).
CC -!- FUNCTION: Transcription factor (By similarity). Probably acts
CC downstream of the Wnt signaling pathway (PubMed:24569038).
CC {ECO:0000250|UniProtKB:Q6BEB4, ECO:0000269|PubMed:24569038}.
CC -!- INTERACTION:
CC Q22678; O02482: unc-37; NbExp=5; IntAct=EBI-2420648, EBI-314716;
CC -!- DEVELOPMENTAL STAGE: Expressed during the larval L1 to adult stages,
CC with little or no change in transcript levels (PubMed:24569038).
CC Expressed in several head neurons during L4 larval stage in
CC hermaphrodites (PubMed:24569038). {ECO:0000269|PubMed:24569038}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown causes hypodermal or
CC cuticular rupture, typically in the anterior body region
CC (PubMed:24569038). Abnormal gap between the outer layer of hypodermis
CC and muscle and the internal organs, perhaps due to defects in cuticle
CC integrity (PubMed:24569038). {ECO:0000269|PubMed:24569038}.
CC -!- SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
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DR EMBL; BX284602; CAA88877.1; -; Genomic_DNA.
DR PIR; T25118; T25118.
DR RefSeq; NP_495833.1; NM_063432.1.
DR AlphaFoldDB; Q22678; -.
DR SMR; Q22678; -.
DR IntAct; Q22678; 4.
DR STRING; 6239.T22C8.5; -.
DR PaxDb; Q22678; -.
DR EnsemblMetazoa; T22C8.5.1; T22C8.5.1; WBGene00011926.
DR GeneID; 188733; -.
DR KEGG; cel:CELE_T22C8.5; -.
DR UCSC; T22C8.5; c. elegans.
DR CTD; 188733; -.
DR WormBase; T22C8.5; CE02353; WBGene00011926; sptf-2.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160673; -.
DR HOGENOM; CLU_098774_0_0_1; -.
DR InParanoid; Q22678; -.
DR OMA; THTKEYR; -.
DR OrthoDB; 1591573at2759; -.
DR PhylomeDB; Q22678; -.
DR Reactome; R-CEL-2173796; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
DR Reactome; R-CEL-6807505; RNA polymerase II transcribes snRNA genes.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00011926; Expressed in larva and 2 other tissues.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW Metal-binding; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..166
FT /note="Specificity protein transcription factor 2"
FT /id="PRO_0000455701"
FT ZN_FING 77..101
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 107..131
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 137..160
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 17..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 166 AA; 18879 MW; ABB1BAA42C4D2216 CRC64;
MDGAATKFFR PWESHGSYHH SLPSISPPDS PASTSASSSS SSIGANELTT KRRKCERCTC
PNCKAIKHGD RGSQHTHLCS VPGCGKTYKK TSHLRAHLRK HTGDRPFVCD WFDCGKRFDR
SDQLIRHKRT HTKEYRFACK FCIRQFSRSD HLQQHLTSVH NIVVVD
