SPTSA_DANRE
ID SPTSA_DANRE Reviewed; 68 AA.
AC Q5BJC1;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Serine palmitoyltransferase small subunit A;
DE AltName: Full=Small subunit of serine palmitoyltransferase A;
DE Short=ssSPTa;
GN Name=sptssa; Synonyms=ssspta; ORFNames=zgc:112487;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Stimulates the activity of serine palmitoyltransferase (SPT).
CC The composition of the serine palmitoyltransferase (SPT) complex
CC determines the substrate preference (By similarity).
CC {ECO:0000250|UniProtKB:Q969W0}.
CC -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC -!- SUBUNIT: Interacts with sptlc1; the interaction is direct. Component of
CC the serine palmitoyltransferase (SPT) complex (By similarity).
CC {ECO:0000250|UniProtKB:Q969W0}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SPTSS family. SPTSSA subfamily.
CC {ECO:0000305}.
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DR EMBL; BC091542; AAH91542.1; -; mRNA.
DR RefSeq; NP_001087196.1; NM_001093727.1.
DR AlphaFoldDB; Q5BJC1; -.
DR SMR; Q5BJC1; -.
DR STRING; 7955.ENSDARP00000095888; -.
DR PaxDb; Q5BJC1; -.
DR Ensembl; ENSDART00000105117; ENSDARP00000095888; ENSDARG00000071203.
DR GeneID; 541337; -.
DR KEGG; dre:541337; -.
DR CTD; 171546; -.
DR ZFIN; ZDB-GENE-050320-26; sptssa.
DR eggNOG; ENOG502S4Q3; Eukaryota.
DR GeneTree; ENSGT00390000002766; -.
DR HOGENOM; CLU_187811_1_0_1; -.
DR InParanoid; Q5BJC1; -.
DR OMA; AWKQISW; -.
DR OrthoDB; 1627882at2759; -.
DR PhylomeDB; Q5BJC1; -.
DR TreeFam; TF328418; -.
DR Reactome; R-DRE-1660661; Sphingolipid de novo biosynthesis.
DR UniPathway; UPA00222; -.
DR PRO; PR:Q5BJC1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 17.
DR Bgee; ENSDARG00000071203; Expressed in intestine and 26 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0017059; C:serine C-palmitoyltransferase complex; ISS:UniProtKB.
DR GO; GO:0046513; P:ceramide biosynthetic process; IBA:GO_Central.
DR InterPro; IPR024512; Ser_palmitoyltrfase_ssu-like.
DR Pfam; PF11779; SPT_ssu-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Lipid metabolism; Membrane; Reference proteome;
KW Sphingolipid metabolism; Transmembrane; Transmembrane helix.
FT CHAIN 1..68
FT /note="Serine palmitoyltransferase small subunit A"
FT /id="PRO_0000293705"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 27..31
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 68 AA; 8122 MW; 32C9FE690D7E4B50 CRC64;
MAFGDAWKQL SWFYYQYLLV TALYMLEPWE RTIFNSLLIS VAAMAVYTGY VFMPQHIMAI
LHYFEVVQ
