ID   SPTSA_SALSA             Reviewed;          68 AA.
AC   B9EN89;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 39.
DE   RecName: Full=Serine palmitoyltransferase small subunit A;
DE   AltName: Full=Small subunit of serine palmitoyltransferase A;
DE            Short=ssSPTa;
GN   Name=sptssa; Synonyms=ssspta;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thyroid;
RX   PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA   Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA   Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA   Koop B.F.;
RT   "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT   evolutionary pressures on a post-tetraploidization genome.";
RL   BMC Genomics 11:279-279(2010).
CC   -!- FUNCTION: Stimulates the activity of serine palmitoyltransferase (SPT).
CC       The composition of the serine palmitoyltransferase (SPT) complex
CC       determines the substrate preference (By similarity).
CC       {ECO:0000250|UniProtKB:Q969W0}.
CC   -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC   -!- SUBUNIT: Interacts with sptlc1; the interaction is direct. Component of
CC       the serine palmitoyltransferase (SPT) complex (By similarity).
CC       {ECO:0000250|UniProtKB:Q969W0}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SPTSS family. SPTSSA subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BT057114; ACM08986.1; -; mRNA.
DR   RefSeq; NP_001139976.1; NM_001146504.2.
DR   AlphaFoldDB; B9EN89; -.
DR   SMR; B9EN89; -.
DR   STRING; 8030.ENSSSAP00000088162; -.
DR   GeneID; 100286565; -.
DR   KEGG; sasa:100286565; -.
DR   CTD; 171546; -.
DR   OMA; AWKQISW; -.
DR   OrthoDB; 1627882at2759; -.
DR   UniPathway; UPA00222; -.
DR   Proteomes; UP000087266; Chromosome ssa09.
DR   Bgee; ENSSSAG00000070042; Expressed in nose and 16 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0017059; C:serine C-palmitoyltransferase complex; ISS:UniProtKB.
DR   GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR024512; Ser_palmitoyltrfase_ssu-like.
DR   Pfam; PF11779; SPT_ssu-like; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Lipid metabolism; Membrane; Reference proteome;
KW   Sphingolipid metabolism; Transmembrane; Transmembrane helix.
FT   CHAIN           1..68
FT                   /note="Serine palmitoyltransferase small subunit A"
FT                   /id="PRO_0000378915"
FT   TOPO_DOM        1..9
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        10..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        27..31
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..68
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   68 AA;  8167 MW;  BCC39C84DF703F15 CRC64;
     MAFEDVWKKI SWLYYQYILV TALYMLEPWE RAIFNSILIS VAGMAVYTGY VFMPQHIMAI
     LQYFEMVQ