ID   SPTSA_XENTR             Reviewed;          80 AA.
AC   Q6DFT6;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Serine palmitoyltransferase small subunit A;
DE   AltName: Full=Small subunit of serine palmitoyltransferase A;
DE            Short=ssSPTa;
GN   Name=sptssa; Synonyms=ssspta;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stimulates the activity of serine palmitoyltransferase (SPT).
CC       The composition of the serine palmitoyltransferase (SPT) complex
CC       determines the substrate preference (By similarity).
CC       {ECO:0000250|UniProtKB:Q969W0}.
CC   -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC   -!- SUBUNIT: Interacts with sptlc1; the interaction is direct. Component of
CC       the serine palmitoyltransferase (SPT) complex (By similarity).
CC       {ECO:0000250|UniProtKB:Q969W0}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SPTSS family. SPTSSA subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC076647; AAH76647.1; -; mRNA.
DR   RefSeq; NP_001005001.1; NM_001005001.1.
DR   AlphaFoldDB; Q6DFT6; -.
DR   SMR; Q6DFT6; -.
DR   STRING; 8364.ENSXETP00000053539; -.
DR   PaxDb; Q6DFT6; -.
DR   DNASU; 448487; -.
DR   GeneID; 448487; -.
DR   KEGG; xtr:448487; -.
DR   CTD; 171546; -.
DR   Xenbase; XB-GENE-949952; sptssa.
DR   eggNOG; ENOG502S4Q3; Eukaryota.
DR   InParanoid; Q6DFT6; -.
DR   OrthoDB; 1627882at2759; -.
DR   Reactome; R-XTR-1660661; Sphingolipid de novo biosynthesis.
DR   UniPathway; UPA00222; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0017059; C:serine C-palmitoyltransferase complex; ISS:UniProtKB.
DR   GO; GO:0046513; P:ceramide biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR024512; Ser_palmitoyltrfase_ssu-like.
DR   Pfam; PF11779; SPT_ssu-like; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Lipid metabolism; Membrane; Reference proteome;
KW   Sphingolipid metabolism; Transmembrane; Transmembrane helix.
FT   CHAIN           1..80
FT                   /note="Serine palmitoyltransferase small subunit A"
FT                   /id="PRO_0000293708"
FT   TOPO_DOM        1..21
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        22..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        39..43
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        67..80
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   80 AA;  9496 MW;  0CBFC2E31DE24FFC CRC64;
     MKVSCEDING PRSSLSRAWN HMSWLYYQYL LVTALYMLEP WERTIFNSML VSIVGMALYT
     GYIFMPQHIL AILHYFEIVQ