ID   SPTSB_XENLA             Reviewed;          80 AA.
AC   Q66J05;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Serine palmitoyltransferase small subunit B;
DE   AltName: Full=Protein ADMP;
DE   AltName: Full=Small subunit of serine palmitoyltransferase B;
DE            Short=ssSPTb;
GN   Name=sptssb; Synonyms=admp, sssptb;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stimulates the activity of serine palmitoyltransferase (SPT).
CC       The composition of the serine palmitoyltransferase (SPT) complex
CC       determines the substrate preference (By similarity).
CC       {ECO:0000250|UniProtKB:Q8NFR3}.
CC   -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC   -!- SUBUNIT: Interacts with sptlc1; the interaction is direct. Component of
CC       the serine palmitoyltransferase (SPT) complex (By similarity).
CC       {ECO:0000250|UniProtKB:Q8NFR3}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SPTSS family. SPTSSB subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC081119; AAH81119.1; -; mRNA.
DR   RefSeq; NP_001087706.1; NM_001094237.1.
DR   AlphaFoldDB; Q66J05; -.
DR   SMR; Q66J05; -.
DR   DNASU; 447530; -.
DR   GeneID; 447530; -.
DR   KEGG; xla:447530; -.
DR   CTD; 447530; -.
DR   Xenbase; XB-GENE-6078037; sptssb.L.
DR   OrthoDB; 1627882at2759; -.
DR   UniPathway; UPA00222; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 447530; Expressed in egg cell and 11 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0017059; C:serine C-palmitoyltransferase complex; ISS:UniProtKB.
DR   GO; GO:0046513; P:ceramide biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0007029; P:endoplasmic reticulum organization; ISS:UniProtKB.
DR   GO; GO:1904220; P:regulation of serine C-palmitoyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0030148; P:sphingolipid biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR024512; Ser_palmitoyltrfase_ssu-like.
DR   Pfam; PF11779; SPT_ssu-like; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Lipid metabolism; Membrane; Reference proteome;
KW   Sphingolipid metabolism; Transmembrane; Transmembrane helix.
FT   CHAIN           1..80
FT                   /note="Serine palmitoyltransferase small subunit B"
FT                   /id="PRO_0000378918"
FT   TOPO_DOM        1..11
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        12..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..36
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        58..80
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   80 AA;  9471 MW;  03D06AA82F5C4FA7 CRC64;
     MDVKHIKDYL SWLYYQYLLI TCSYVLEPWE QSIFNTLLLT IIAMVIYSSY IFIPIHVRLA
     VEFFSRIFGG QHESTVALMS