ID   SPX1_LACLA              Reviewed;         128 AA.
AC   Q9CI20;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Global transcriptional regulator Spx 1 {ECO:0000255|HAMAP-Rule:MF_01132};
GN   Name=spx1 {ECO:0000255|HAMAP-Rule:MF_01132}; OrderedLocusNames=LL0546;
GN   ORFNames=L132585;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- FUNCTION: Global transcriptional regulator that plays a key role in
CC       stress response and exerts either positive or negative regulation of
CC       genes. Acts by interacting with the C-terminal domain of the alpha
CC       subunit of the RNA polymerase (RNAP). This interaction can enhance
CC       binding of RNAP to the promoter region of target genes and stimulate
CC       their transcription, or block interaction of RNAP with activator.
CC       {ECO:0000255|HAMAP-Rule:MF_01132}.
CC   -!- SUBUNIT: Interacts with the C-terminal domain of the alpha subunit of
CC       the RNAP. {ECO:0000255|HAMAP-Rule:MF_01132}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01132}.
CC   -!- SIMILARITY: Belongs to the ArsC family. Spx subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01132}.
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DR   EMBL; AE005176; AAK04644.1; -; Genomic_DNA.
DR   PIR; B86693; B86693.
DR   RefSeq; NP_266702.1; NC_002662.1.
DR   RefSeq; WP_010905435.1; NC_002662.1.
DR   AlphaFoldDB; Q9CI20; -.
DR   SMR; Q9CI20; -.
DR   STRING; 272623.L132585; -.
DR   PaxDb; Q9CI20; -.
DR   EnsemblBacteria; AAK04644; AAK04644; L132585.
DR   GeneID; 60355856; -.
DR   GeneID; 66441444; -.
DR   KEGG; lla:L132585; -.
DR   PATRIC; fig|272623.7.peg.584; -.
DR   eggNOG; COG1393; Bacteria.
DR   HOGENOM; CLU_116644_1_1_9; -.
DR   OMA; IMIDDKR; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   HAMAP; MF_01132; Spx; 1.
DR   InterPro; IPR006660; Arsenate_reductase-like.
DR   InterPro; IPR023731; Spx.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR006504; Tscrpt_reg_Spx/MgsR.
DR   PANTHER; PTHR30041; PTHR30041; 1.
DR   Pfam; PF03960; ArsC; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR01617; arsC_related; 1.
DR   PROSITE; PS51353; ARSC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Disulfide bond; Redox-active center; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..128
FT                   /note="Global transcriptional regulator Spx 1"
FT                   /id="PRO_0000162553"
FT   DISULFID        10..13
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01132"
SQ   SEQUENCE   128 AA;  14867 MW;  E37E17E75A1FEFB2 CRC64;
     MIDLYLSPSC TSCRKARAWL QSHKVPFVEH NILTQPMTTN DLRHILTKTE NGTEDIISTR
     SKVFQKLAVD VDNLTINELL DLVTEFPNLL RRPIITDSKH LQIGFNEDEI RAFLPREYRR
     AEMLSTID