SPX2_ARATH
ID SPX2_ARATH Reviewed; 287 AA.
AC O48781; Q8GWZ3;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=SPX domain-containing protein 2 {ECO:0000303|PubMed:18315545};
DE AltName: Full=Protein SPX DOMAIN GENE 2 {ECO:0000303|PubMed:18315545};
DE Short=AtSPX2 {ECO:0000303|PubMed:18315545};
GN Name=SPX2 {ECO:0000303|PubMed:18315545};
GN OrderedLocusNames=At2g26660 {ECO:0000312|Araport:AT2G26660};
GN ORFNames=F18A8.3 {ECO:0000312|EMBL:AAB95300.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 122-287.
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 128-287.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY, SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=18315545; DOI=10.1111/j.1365-313x.2008.03460.x;
RA Duan K., Yi K., Dang L., Huang H., Wu W., Wu P.;
RT "Characterization of a sub-family of Arabidopsis genes with the SPX domain
RT reveals their diverse functions in plant tolerance to phosphorus
RT starvation.";
RL Plant J. 54:965-975(2008).
RN [6]
RP DISRUPTION PHENOTYPE.
RX PubMed=25271326; DOI=10.1073/pnas.1404654111;
RA Puga M.I., Mateos I., Charukesi R., Wang Z., Franco-Zorrilla J.M.,
RA de Lorenzo L., Irigoyen M.L., Masiero S., Bustos R., Rodriguez J.,
RA Leyva A., Rubio V., Sommer H., Paz-Ares J.;
RT "SPX1 is a phosphate-dependent inhibitor of PHOSPHATE STARVATION RESPONSE 1
RT in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:14947-14952(2014).
CC -!- FUNCTION: May inhibit PHR1 DNA-binding activity in a Pi-dependent
CC manner. {ECO:0000305|PubMed:25271326}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18315545}.
CC -!- INDUCTION: Up-regulated under phosphate starvation.
CC {ECO:0000269|PubMed:18315545}.
CC -!- DISRUPTION PHENOTYPE: No effect on Pi accumulation, due to the
CC redundancy with SPX1. Spx1 and spx2 double mutants have an increased
CC root-to-shoot growth ratio and a reduced rot hair size when grown in
CC Pi-sufficient conditions. {ECO:0000269|PubMed:25271326}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC43140.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC003105; AAB95300.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07871.1; -; Genomic_DNA.
DR EMBL; AK118537; BAC43140.1; ALT_INIT; mRNA.
DR EMBL; BT003688; AAO39916.1; -; mRNA.
DR PIR; C84663; C84663.
DR RefSeq; NP_180234.1; NM_128223.3.
DR AlphaFoldDB; O48781; -.
DR SMR; O48781; -.
DR STRING; 3702.AT2G26660.1; -.
DR PaxDb; O48781; -.
DR PRIDE; O48781; -.
DR ProteomicsDB; 245252; -.
DR EnsemblPlants; AT2G26660.1; AT2G26660.1; AT2G26660.
DR GeneID; 817207; -.
DR Gramene; AT2G26660.1; AT2G26660.1; AT2G26660.
DR KEGG; ath:AT2G26660; -.
DR Araport; AT2G26660; -.
DR TAIR; locus:2043844; AT2G26660.
DR eggNOG; KOG1161; Eukaryota.
DR HOGENOM; CLU_057600_1_1_1; -.
DR InParanoid; O48781; -.
DR OMA; GNDRSAN; -.
DR OrthoDB; 1345784at2759; -.
DR PhylomeDB; O48781; -.
DR PRO; PR:O48781; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O48781; baseline and differential.
DR Genevisible; O48781; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0071456; P:cellular response to hypoxia; HEP:TAIR.
DR GO; GO:0016036; P:cellular response to phosphate starvation; IEP:TAIR.
DR InterPro; IPR004331; SPX_dom.
DR InterPro; IPR031142; SPX_prot.
DR PANTHER; PTHR45978; PTHR45978; 1.
DR Pfam; PF03105; SPX; 3.
DR PROSITE; PS51382; SPX; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome.
FT CHAIN 1..287
FT /note="SPX domain-containing protein 2"
FT /id="PRO_0000398343"
FT DOMAIN 1..162
FT /note="SPX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00714"
FT REGION 36..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 287 AA; 32989 MW; 8CB39A41A4BF43D7 CRC64;
MKFGKSLSNQ IEETLPEWRD KFLSYKELKK KLKLMEPRSV ENRPNKRSRS DSNSVDTDPT
VGMTKEELDF ISLLEDELEK FNSFFVEQEE EYIIRLKELK DQVAKAKNSN EEMINIKKEI
VDFHGEMVLL MNYSALNYTG LAKILKKYDK RTGALIRLPF IQKVLQEPFF TTDLLNTFVK
ECEAMLDRLF PSNKSRNLDE EGEPTTSGMV KTGTDDSELL RVPKELSEIE YMESLYMKST
VSALKVLKEI RSGSSTVSVF SLPPLPASGL EDDSWKKKVG VLEQVAK
