ID   SPX3_ARATH              Reviewed;         245 AA.
AC   Q5PP62;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=SPX domain-containing protein 3;
DE   AltName: Full=Protein SPX DOMAIN GENE 3;
DE            Short=AtSPX3;
GN   Name=SPX3; OrderedLocusNames=At2g45130; ORFNames=T14P1.6;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   GENE FAMILY, INDUCTION, AND FUNCTION.
RX   PubMed=18315545; DOI=10.1111/j.1365-313x.2008.03460.x;
RA   Duan K., Yi K., Dang L., Huang H., Wu W., Wu P.;
RT   "Characterization of a sub-family of Arabidopsis genes with the SPX domain
RT   reveals their diverse functions in plant tolerance to phosphorus
RT   starvation.";
RL   Plant J. 54:965-975(2008).
CC   -!- FUNCTION: Plays a positive role in plant adaptation to phosphate
CC       starvation and exerts negative feedback regulation of SPX1.
CC       {ECO:0000269|PubMed:18315545}.
CC   -!- INDUCTION: Up-regulated under phosphate starvation.
CC       {ECO:0000269|PubMed:18315545}.
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DR   EMBL; CP002685; AEC10511.1; -; Genomic_DNA.
DR   EMBL; BT020235; AAV74229.1; -; mRNA.
DR   EMBL; BT020499; AAW39000.1; -; mRNA.
DR   PIR; G84886; G84886.
DR   RefSeq; NP_182038.1; NM_130076.2.
DR   AlphaFoldDB; Q5PP62; -.
DR   SMR; Q5PP62; -.
DR   STRING; 3702.AT2G45130.1; -.
DR   PaxDb; Q5PP62; -.
DR   PRIDE; Q5PP62; -.
DR   ProteomicsDB; 245247; -.
DR   EnsemblPlants; AT2G45130.1; AT2G45130.1; AT2G45130.
DR   GeneID; 819120; -.
DR   Gramene; AT2G45130.1; AT2G45130.1; AT2G45130.
DR   KEGG; ath:AT2G45130; -.
DR   Araport; AT2G45130; -.
DR   TAIR; locus:2055572; AT2G45130.
DR   eggNOG; KOG1161; Eukaryota.
DR   HOGENOM; CLU_057600_1_1_1; -.
DR   InParanoid; Q5PP62; -.
DR   OMA; CGHNDEM; -.
DR   OrthoDB; 1345784at2759; -.
DR   PhylomeDB; Q5PP62; -.
DR   PRO; PR:Q5PP62; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q5PP62; baseline and differential.
DR   Genevisible; Q5PP62; AT.
DR   GO; GO:0016036; P:cellular response to phosphate starvation; IEP:TAIR.
DR   GO; GO:0080040; P:positive regulation of cellular response to phosphate starvation; IMP:TAIR.
DR   InterPro; IPR004331; SPX_dom.
DR   InterPro; IPR031142; SPX_prot.
DR   PANTHER; PTHR45978; PTHR45978; 1.
DR   Pfam; PF03105; SPX; 2.
DR   PROSITE; PS51382; SPX; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..245
FT                   /note="SPX domain-containing protein 3"
FT                   /id="PRO_0000398344"
FT   DOMAIN          1..142
FT                   /note="SPX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00714"
SQ   SEQUENCE   245 AA;  28149 MW;  7408A82813733184 CRC64;
     MKFGKRIKEQ IQESLPEWRD KFLRYKELKN LISSPAPVES IFVGLLNAEI DKFNAFFVEQ
     EEDFIIHHKE LQYRIQRLVE KCGHNDEMSR ENISEIRKDI VNFHGEMVLL VNYSNINYTG
     LAKILKKYDK RTRGGLRSPF IQKVLHQPFF KTDLVSRLVR EWETTMDAVD PVKVAEAEGY
     ERCAAVTSAA AGEGIFRNTV AALLTMKEMR RGSSTYSAFS LPPLNISDSD NVLRSLHLSS
     PIPIP