ID   SPX3_BOVIN              Reviewed;         495 AA.
AC   Q17QZ3;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Sugar phosphate exchanger 3;
DE   AltName: Full=Solute carrier family 37 member 3;
GN   Name=SLC37A3; Synonyms=SPX3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q8NCC5}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. {ECO:0000305}.
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DR   EMBL; BC118104; AAI18105.1; -; mRNA.
DR   RefSeq; NP_001068752.1; NM_001075284.1.
DR   AlphaFoldDB; Q17QZ3; -.
DR   SMR; Q17QZ3; -.
DR   STRING; 9913.ENSBTAP00000033404; -.
DR   PaxDb; Q17QZ3; -.
DR   Ensembl; ENSBTAT00000033491; ENSBTAP00000033404; ENSBTAG00000012239.
DR   Ensembl; ENSBTAT00000070087; ENSBTAP00000056723; ENSBTAG00000012239.
DR   GeneID; 506910; -.
DR   KEGG; bta:506910; -.
DR   CTD; 84255; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012239; -.
DR   VGNC; VGNC:34844; SLC37A3.
DR   eggNOG; KOG2533; Eukaryota.
DR   GeneTree; ENSGT00940000163296; -.
DR   HOGENOM; CLU_001265_31_6_1; -.
DR   InParanoid; Q17QZ3; -.
DR   OMA; YQWQVFL; -.
DR   OrthoDB; 964162at2759; -.
DR   TreeFam; TF314991; -.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000012239; Expressed in saliva-secreting gland and 105 other tissues.
DR   ExpressionAtlas; Q17QZ3; baseline.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR000849; Sugar_P_transporter.
DR   Pfam; PF07690; MFS_1; 1.
DR   PIRSF; PIRSF002808; Hexose_phosphate_transp; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome;
KW   Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..495
FT                   /note="Sugar phosphate exchanger 3"
FT                   /id="PRO_0000309277"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        429..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        453..473
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        58
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        267
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   495 AA;  54430 MW;  8CAB9BA81B161C5D CRC64;
     MAWPRIFQRG ALLSRFSHHH MVVFLLTFFS YSLLHASRKT FSNVKVSISK QWTPSAFNKS
     TELLPVEIWS SNHLFPSAEE ATLFLGMLDT IFLFSYAVGL FISGIVGDRL NLRWVLSFGM
     CSSALVVFVF GTLTEWLHFY NKGLYCSLWI VNGLLQSTGW PCVVAVMGNW FGKAGRGVVF
     GLWSACASVG NILGACLASS VLQYGYEYAF LVTAAVQFAG GIIIFFGLLV SPEEIGIPGI
     ETEDNFEEDS HRPLINGAEN EDEAEPNYSI QEGNTVTQVK AISFYQACCL PGVIAYSLAY
     ACLKLVNYSF FFWLPFYLSN NFGWKEAEAD QLSIWYDVGG IIGGTLQGFI SDMLQKRAPV
     LALSLLLAIG SLVGYSRSPN DKSINALLMA VTGFFIGGPS NMISSAISAD LGRQELIQGS
     SEALATVTGI VDGTGSIGAA VGQYLVSLIQ DNLGWMWVFY FFILMTSCTV LFISPLIVRE
     TCSLMQRRQT RVLNE