ID   SPX3_CHICK              Reviewed;         501 AA.
AC   Q5F3N0;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Sugar phosphate exchanger 3;
DE   AltName: Full=Solute carrier family 37 member 3;
GN   Name=SLC37A3; Synonyms=SPX3; ORFNames=RCJMB04_12a19;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q8NCC5}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ851620; CAH65254.1; -; mRNA.
DR   RefSeq; NP_001012556.1; NM_001012538.1.
DR   AlphaFoldDB; Q5F3N0; -.
DR   SMR; Q5F3N0; -.
DR   STRING; 9031.ENSGALP00000020927; -.
DR   PaxDb; Q5F3N0; -.
DR   GeneID; 418112; -.
DR   KEGG; gga:418112; -.
DR   CTD; 84255; -.
DR   VEuPathDB; HostDB:geneid_418112; -.
DR   eggNOG; KOG2533; Eukaryota.
DR   InParanoid; Q5F3N0; -.
DR   OrthoDB; 964162at2759; -.
DR   PhylomeDB; Q5F3N0; -.
DR   PRO; PR:Q5F3N0; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR000849; Sugar_P_transporter.
DR   Pfam; PF07690; MFS_1; 1.
DR   PIRSF; PIRSF002808; Hexose_phosphate_transp; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome;
KW   Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..501
FT                   /note="Sugar phosphate exchanger 3"
FT                   /id="PRO_0000309280"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        364..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        435..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        459..479
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          244..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        273
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   501 AA;  54911 MW;  413BB6987513801D CRC64;
     MAVPGSSRRQ PSNRGLVSHC THHHIVVFLL TFFSYSLLHA SRKTFSNVKV SISSQWTPSC
     LNSTTFELRP NELWNSNHLF PNAEEATLFL GTLDTIFLFS YAVGLFVSGI VGDRLNLRWV
     LSFGMCSSAL VVFFFGTLTE WLHFYNKWFY CCLWVVNGLL QSTGWPCVVA VMGNWFGKAG
     RGFVFGLWSA CASVGNILGA FLASCVLKYG YEYAFLVTAS VQFAGGVIVF CGLLTSPKEV
     GLPELGADEE GSVEEDANRP LMGDDDADDD EGNYSIQAAD TDSQPKAIGF FQACCLPGVV
     LYSLAYACLK LVNYSFFFWL PFYLSNNFGW KEAEADQLSI WYDVGGIIGG TIQGLISDVL
     QKRAPVLAIS LLFAVGSLFG YSRSPNSKPI NAVIMAITGF FIGGPSNMIS SAISADLGRQ
     DLVRGSSEAL ATVTGIVDGT GSIGAAVGQY LVSLIQENLG WMWVFYFFIL MASSTILFIS
     PLIVREIRLL LHERRLRMLA E