SPX3_HUMAN
ID SPX3_HUMAN Reviewed; 494 AA.
AC Q8NCC5; Q6PIU7; Q86SS4; Q9BQG7;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Sugar phosphate exchanger 3;
DE AltName: Full=Solute carrier family 37 member 3;
GN Name=SLC37A3; Synonyms=SPX3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Amygdala;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=21949678; DOI=10.1371/journal.pone.0023157;
RA Pan C.J., Chen S.Y., Jun H.S., Lin S.R., Mansfield B.C., Chou J.Y.;
RT "SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate
RT antiporters.";
RL PLoS ONE 6:E23157-E23157(2011).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:21949678}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8NCC5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NCC5-2; Sequence=VSP_029114;
CC Name=3;
CC IsoId=Q8NCC5-3; Sequence=VSP_029113, VSP_029115;
CC -!- TISSUE SPECIFICITY: Expressed in liver, kidney, intestine and pancreas.
CC {ECO:0000269|PubMed:21949678}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. {ECO:0000305}.
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DR EMBL; AL136583; CAB66518.1; -; mRNA.
DR EMBL; AK074823; BAC11231.1; -; mRNA.
DR EMBL; AC093087; AAQ93361.1; -; Genomic_DNA.
DR EMBL; CH236950; EAL24030.1; -; Genomic_DNA.
DR EMBL; CH236950; EAL24031.1; -; Genomic_DNA.
DR EMBL; CH471070; EAW83944.1; -; Genomic_DNA.
DR EMBL; CH471070; EAW83945.1; -; Genomic_DNA.
DR EMBL; CH471070; EAW83947.1; -; Genomic_DNA.
DR EMBL; BC028380; AAH28380.1; -; mRNA.
DR EMBL; BC046567; AAH46567.1; -; mRNA.
DR CCDS; CCDS5858.1; -. [Q8NCC5-3]
DR CCDS; CCDS5859.1; -. [Q8NCC5-1]
DR CCDS; CCDS75669.1; -. [Q8NCC5-2]
DR RefSeq; NP_001274427.1; NM_001287498.1. [Q8NCC5-2]
DR RefSeq; NP_115671.1; NM_032295.3. [Q8NCC5-3]
DR RefSeq; NP_996996.1; NM_207113.2. [Q8NCC5-1]
DR RefSeq; XP_016868201.1; XM_017012712.1.
DR RefSeq; XP_016868202.1; XM_017012713.1.
DR AlphaFoldDB; Q8NCC5; -.
DR SMR; Q8NCC5; -.
DR BioGRID; 123982; 65.
DR IntAct; Q8NCC5; 22.
DR STRING; 9606.ENSP00000321498; -.
DR TCDB; 2.A.1.4.9; the major facilitator superfamily (mfs).
DR GlyGen; Q8NCC5; 2 sites.
DR iPTMnet; Q8NCC5; -.
DR BioMuta; SLC37A3; -.
DR DMDM; 160358732; -.
DR jPOST; Q8NCC5; -.
DR MassIVE; Q8NCC5; -.
DR MaxQB; Q8NCC5; -.
DR PaxDb; Q8NCC5; -.
DR PeptideAtlas; Q8NCC5; -.
DR PRIDE; Q8NCC5; -.
DR ProteomicsDB; 72872; -. [Q8NCC5-1]
DR ProteomicsDB; 72873; -. [Q8NCC5-2]
DR ProteomicsDB; 72874; -. [Q8NCC5-3]
DR Antibodypedia; 18263; 38 antibodies from 19 providers.
DR DNASU; 84255; -.
DR Ensembl; ENST00000326232.14; ENSP00000321498.9; ENSG00000157800.18. [Q8NCC5-1]
DR Ensembl; ENST00000340308.7; ENSP00000343358.3; ENSG00000157800.18. [Q8NCC5-3]
DR Ensembl; ENST00000447932.6; ENSP00000397481.2; ENSG00000157800.18. [Q8NCC5-2]
DR GeneID; 84255; -.
DR KEGG; hsa:84255; -.
DR MANE-Select; ENST00000326232.14; ENSP00000321498.9; NM_207113.3; NP_996996.1.
DR UCSC; uc003vvo.5; human. [Q8NCC5-1]
DR CTD; 84255; -.
DR DisGeNET; 84255; -.
DR GeneCards; SLC37A3; -.
DR HGNC; HGNC:20651; SLC37A3.
DR HPA; ENSG00000157800; Low tissue specificity.
DR MIM; 619137; gene.
DR neXtProt; NX_Q8NCC5; -.
DR OpenTargets; ENSG00000157800; -.
DR PharmGKB; PA134895240; -.
DR VEuPathDB; HostDB:ENSG00000157800; -.
DR eggNOG; KOG2533; Eukaryota.
DR GeneTree; ENSGT00940000163296; -.
DR HOGENOM; CLU_001265_31_6_1; -.
DR InParanoid; Q8NCC5; -.
DR OMA; YQWQVFL; -.
DR OrthoDB; 964162at2759; -.
DR PhylomeDB; Q8NCC5; -.
DR TreeFam; TF314991; -.
DR PathwayCommons; Q8NCC5; -.
DR SignaLink; Q8NCC5; -.
DR BioGRID-ORCS; 84255; 11 hits in 1075 CRISPR screens.
DR ChiTaRS; SLC37A3; human.
DR GenomeRNAi; 84255; -.
DR Pharos; Q8NCC5; Tdark.
DR PRO; PR:Q8NCC5; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8NCC5; protein.
DR Bgee; ENSG00000157800; Expressed in body of uterus and 169 other tissues.
DR ExpressionAtlas; Q8NCC5; baseline and differential.
DR Genevisible; Q8NCC5; HS.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IDA:UniProtKB.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR000849; Sugar_P_transporter.
DR Pfam; PF07690; MFS_1; 1.
DR PIRSF; PIRSF002808; Hexose_phosphate_transp; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Endoplasmic reticulum; Glycoprotein; Membrane;
KW Reference proteome; Sugar transport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..494
FT /note="Sugar phosphate exchanger 3"
FT /id="PRO_0000309278"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 386..406
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 452..472
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 266
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 342..443
FT /note="GGTLQGFISDVLQKRAPVLALSLLLAVGSLIGYSRSPNDKSINALLMTVTGF
FT FIGGPSNMISSAISADLGRQELIQRSSEALATVTGIVDGSGSIGAAVGQY -> VFSVS
FT DPGQARMDVGFLLFHSHDKLYNCVYLAINSEGNILSRAKETGSHIEGVTGARETERTMS
FT ATSGPLGLRVCPNLGLSRSSSLILDCQASLNTASHLRC (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:11230166"
FT /id="VSP_029113"
FT VAR_SEQ 377..392
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029114"
FT VAR_SEQ 444..494
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:11230166"
FT /id="VSP_029115"
FT CONFLICT 65
FT /note="V -> L (in Ref. 1; BAC11231)"
FT /evidence="ECO:0000305"
FT CONFLICT 281
FT /note="I -> M (in Ref. 1; BAC11231)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 494 AA; 54486 MW; 95131438A803555E CRC64;
MAWPNVFQRG SLLSQFSHHH VVVFLLTFFS YSLLHASRKT FSNVKVSISE QWTPSAFNTS
VELPVEIWSS NHLFPSAEKA TLFLGTLDTI FLFSYAVGLF ISGIVGDRLN LRWVLSFGMC
SSALVVFVFG ALTEWLRFYN KWLYCCLWIV NGLLQSTGWP CVVAVMGNWF GKAGRGVVFG
LWSACASVGN ILGACLASSV LQYGYEYAFL VTASVQFAGG IVIFFGLLVS PEEIGLSGIE
AEENFEEDSH RPLINGGENE DEYEPNYSIQ DDSSVAQVKA ISFYQACCLP GVIPYSLAYA
CLKLVNYSFF FWLPFYLSNN FGWKEAEADK LSIWYDVGGI IGGTLQGFIS DVLQKRAPVL
ALSLLLAVGS LIGYSRSPND KSINALLMTV TGFFIGGPSN MISSAISADL GRQELIQRSS
EALATVTGIV DGSGSIGAAV GQYLVSLIRD KLGWMWVFYF FILMTSCTIV FISPLIVREI
FSLVLRRQAH ILRE
